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Zopiclone
drug data and news
Zopiclone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Zopiclone | ||
| Brand Names/Synonyms | Amoban; Amovane; Imovance; Imovane; Lunesta; Sopivan; ZOPICLONE, 98.5%; Zimovane; Zonisamide; Zopiclona [Inn-Spanish]; Zopiclone; Zopiclone [Ban:Inn:Jan]; Zopiclonum [Inn-Latin] | ||
| Indication | For the short-term treatment of insomnia. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Zopiclone is a nonbenzodiazepine hypnotic from the pyrazolopyrimidine class and is indicated for the short-term treatment of insomnia. While Zopiclone is a hypnotic agent with a chemical structure unrelated to benzodiazepines, barbiturates, or other drugs with known hypnotic properties, it interacts with the gamma-aminobutyric acid-benzodiazepine (GABABZ) receptor complex. Subunit modulation of the GABABZ receptor chloride channel macromolecular complex is hypothesized to be responsible for some of the pharmacological properties of benzodiazepines, which include sedative, anxiolytic, muscle relaxant, and anticonvulsive effects in animal models. Zopiclone binds selectively to the brain alpha subunit of the GABA A omega-1 receptor. | ||
| Mechanism Of Action | Zopiclone exerts its action by binding on the benzodiazepine receptor complex and modulation of the GABABZ receptor chloride channel macromolecular complex. | ||
| Zopiclone News (When available) |
Mom netted in drug raid May 9, 2006 Neurocrine Biosciences Reports First Quarter 2006 Results Apr 24, 2006 | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Hypnotics and Sedatives; Anxiolytics sedatives and hypnotics; ATC:N05CF01 | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | [8-(5-chloropyridin-2-yl)-7-oxo-2,5,8-triazabicyclo[4.3.0]nona-1,3,5-trien-9-yl]4-methylpiperazine-1-carboxylate | ||
| Chemical Formula | C17H17ClN6O3 | ||
| Molecular Weight | 388.808 g/mol | ||
| Smiles String | CN1CCN(CC1)C(=O)OC2C3=NC=CN=C3C(=O)N2C4=NC=C(C=C4)Cl | ||
| Melting Point | 178 °C | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | -0.88 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Approximately 5 hours | ||
| Protein Binding [%] | Approximately 45% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Zopiclone.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00356 | ||
| CAS Registry Number | 43200-80-2 | ||
| KEGG Compound ID | C12808 | ||
| PubChem ID | SID:332810 | ||
| PharmGKB ID | PA10236 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2257580 |
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