Zanamivir drug data and news

Zanamivir drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Zanamivir
Brand Names/Synonyms GANA; GG 167; GNA; MODIFIED SIALIC ACID; Relenza; See Remark 8; ZMR; Zanamavir; Zanamivir
Indication For the prevention and treatment of influenza
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Description Not Available
Pharmacology Zanamivir, an antiviral agent, is a neuraminidase inhibitor indicated for treatment of uncomplicated acute illness due to influenza A and B virus in adults and pediatric patients 7 years and older who have been symptomatic for no more than 2 days.
Mechanism Of Action The proposed mechanism of action of zanamivir is via inhibition of influenza virus neuraminidase with the possibility of alteration of virus particle aggregation and release.
Zanamivir News
(When available)

'Flu and children  17 May 2006
There are specific anti-influenza drugs now available (zanamivir and oseltamivir) and these might be prescribed by your doctor if the diagnosis is definite and ... - Health24.com,

Bird Flu May Infect People Through Digestive Tract (Update2)  May 9, 2006
...particles are carried outside the lungs and surrounding tissues to other parts of the body, some antiviral treatments such as inhaled zanamivir, marketed by ... - Bloomberg

Experts weigh bird flu threat  May 14, 2006
...themselves? Two currently available drugs, oseltamivir and zanamivir (sold as Tamiflu and Relenza) seem to have some effect on the virus. ... - San Gabriel Valley Tribune,

Conference of Federal-Provincial Territorial Ministers of Health ...  May 13, 2006
...it is used for treatment. Zanamivir and oseltamivir are examples of neuraminidase inhibitors. These drugs interfere with replication ... - CNW Telbec (Communiqués de presse),

Gen ID to develop new bird flu drugs  May 9, 2006
...avian influenza infection includes the use of antiviral therapy such as ribavirin and amantadine and neuraminidase inhibitors such as oseltamivir and zanamivir ... - Pharmaceutical Business Review

AXE THREAT PLANT WINS 100 JOBS  May 12, 2006
The plant also produces zanamivir, the active ingredient in bird flu vaccine as well as two other lines to treat asthma and inflamed prostates. ... - Glasgow Daily Record,

GSK board okays sale of animal health unit  Apr 28, 2006
...bird flu drug Relenza into India. Relenza is the brandname for Zanamivir, a drug that has to be inhaled. It is the other drug besides ... - Daily News & Analysis,

Cornell Bird Experts Monitor for Signs of Avian Flu (Update2)  May 6, 2006
Zanamivir, the antiviral drug sold by GlaxoSmithKline Plc as the inhaled powder Relenza, may have to be made into an injectable form to effectively treat H5N1 ... - Bloomberg

Live bird flu virus found in victim's blood  May 4, 2006
Currently there are only four flu antivirals on the market and one, zanamivir (sold as Relenza) is administered to the respiratory tract by inhalation. ... - Globe and Mail,

GlaxoSmithKline Awarded $274 Million HHS Contract; Company to ...  May 4, 2006
...recently committed over $2 billion to expand capacity for manufacturing flu vaccine and its anti-viral influenza treatment Relenza(R) (zanamivir for inhalation ... - Drug Newswire (press release),

GSK initiates human trial programme with two H5N1 pandemic flu ...  Apr 20, 2006
...over a billion pounds ($2 billion) to expand capacity for manufacturing flu vaccine and its anti-viral influenza treatment Relenza® (zanamivir for inhalation ... - Vanguard,

Full Text  Apr 20, 2006
...pandemic vaccine will be available, the immediate defenses against pandemic influenza are the neuraminidase-inhibitor antiviral drugs, oseltamivir and zanamivir ... - Science Magazine (subscription)

Dosage Forms POWDER
Drug_Category Antivirals; Enzyme Inhibitors; Neuraminidase Inhibitors; ATC:J05AH01
Absorption 4% to 17% following an orally inhaled dose
Interactions -->Interactions for Zanamivir:

No clinically significant pharmacokinetic drug interactions are predicted based on data from in vitro studies.

Toxicity Not Available
Organisms Affected Influenza A virus; Influenza B virus
Chemical IUPAC Name 5-acetamido-4-guanidino-6-(1,2,3-trihydroxypropyl)-5,6-dihydro-4H-pyran-2-carboxylic acid
Chemical Formula C12H20N4O7
Molecular Weight 332.31 g/mol
Smiles String CC(=O)NC1C(C=C(OC1C(C(CO)O)O)C(=O)O)N=C(N)N
Melting Point Not Available
Water Solubility Not Available
State Solid
LogP/Hphobicity -3.67
Isoelectric Point Not Available
Biotransformation Not metabolized
Half Life 2.5-5.1 hours
Protein Binding [%] <10%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Zanamivir.html
http://www.rxlist.com/cgi/generic2/zanam.htm
Drug Type Approved Drug
Accession No APRD00378
CAS Registry Number 139110-80-8
KEGG Compound ID C08095
PubChem ID SID:197092
PharmGKB ID PA451953
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2240863

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