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Vitamin D3 (Cholecalciferol)
drug data and news
Vitamin D3 (Cholecalciferol) drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Vitamin D3 (Cholecalciferol)
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| Brand Names/Synonyms |
CC; Calciol; Cholecalciferol; Cholecalciferol, D3; Colecalciferol; Delsterol; Delta-D; Deparal; Ebivit; Micro-Dee; Oleovitamin D3; Provitamin D3; Provitamine; Provitina; Ricketon; Trivitan; Vigantol; Vigorsan; Vitamin D3 + Vitamin D (Cholecalciferol) + Vitamin E (D-Alpha Tocopheryl Acetate) + Zinc (Zinc Sulfate)); Prenatal Vitamins and Minerals Tablets (Beta-Carotene + Biotin + Calcium (Calcium Carbonate) + Chromium (Chromic Chloride) + Copper (Cupric Oxide) + D-Pantothen Biotin + Calcium (Calcium Phosphate (Dibasic), Calcium Citrate) + Chromium (Chromic Chloride) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Magnesium (Magnesium Oxide, Magnesium Citrate) + Manganese (Manganese Gluconate) + Molybdenum (Sodium Molybdate) + Nicotinic Acid + Phosphorus (Calcium Phosphate (Dibasic)) + Selenium (Selenium Hvp Chelate) + Vanadium (Vanadium Hvp Chelate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 + Vitamin B2 (Riboflavin, Riboflavin-5-Phosphate) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C + Vitamin D (Cholecalciferol) + Vitamin E (Dl-Alpha Tocopheryl Acetate) + Zinc (Zinc Citrate)); Watkins J.R. (Beta-Carotene (Provitamin a) + Biotin + Chromium (Chromic Chloride) + Copper (Copper Sulfate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iodine (Potassium Iodide) + Iron (Ferrous Fumarate) + Manganese (Manganese Sulfate) + Molybdenum (Sodium Molybdate) + Nicotinamide + Selenium (Selenium Hvp Chelate) + Silicon (Silicon Dioxide) + Vitamin B1 (Thiamine Mononitrate) + Vitamin B12 (Cyanocobalamin) + Vitamin B2 + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C + Vitamin D (Cholecalciferol) + Vitamin E (Dl-Alpha Tocopheryl Acetate, D-Alpha Tocopheryl Acid Succinate) + Zinc (Zinc Hvp Chelate, Zinc Citrate)); Women's Biomultiple Vitamin and Mineral Supplement (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Carbonate) + Choline Bitartrate + Chromium (Yeast) + Copper (Copper Hvp Chelate) + D-Pantothenic Acid + Folic Acid + Inositol + Iodine (Potassium Iodide) + Iron (Ferrous Fumarate) + Magnesium (Magnesium Oxide) + Manganese (Manganese Hvp Chelate) + Methionine + Molybdenum (Molybdenum Citrate) + Nicotinamide + Selenium (Selenium Hvp Chelate) + Silicon Dioxide + Vanadium (Vanadium Citrate) + Vitamin B1 (Thiamine Mononitrate) + Vitamin B2 (Riboflavin) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Ascorbic Acid) + Vitamin D3 (Cholecalciferol) + Vitamin E (D-Alpha Tocopheryl Acetate) + Zinc (Zinc Oxide)); Women's Formula (Biotin + Calcium (Calcium Carbonate, Calcium Ascorbate, Calcium Citrate) + Chromium (Chromium Citrate) + Copper (Copper Gluconate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Iron (Ferrous Fumarate) + Magnesium (Magnesium Oxide) + Manganese (Manganese Gluconate) + Nicotinamide + Selenium (Selenium Hvp Chelate) + Vitamin a (Beta-Carotene) + Vitamin a (Fish Liver Oil, Vitamin a Palmitate) + Vitamin B1 (Thiamine Hydrochloride) + Vitamin B12 (Vitamin B12) + Vitamin B2 (Riboflavin) + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C (Calcium Ascorbate, Ascorbic Acid, Ascorbyl Palmitate) + Vitamin D3 (Cholecalciferol) + Vitamin E (D-Alpha Tocopheryl Acid Succinate) + Zinc (Zinc Sulfate, Zinc Gluconate)); Women's Timed Release Ultra Mega Without Iron (Beta-Carotene (Provitamin a) + Biotin + Calcium (Calcium Carbonate, Calcium Hvp Chelate) + Choline (Choline Bitartrate) + Chromium (Chromium Hvp Chelate) + Copper (Copper Hvp Chelate) + D-Pantothenic Acid (Calcium D-Pantothenate) + Folic Acid + Inositol + Iodine (Kelp) + Magnesium (Magnesium Oxide, Magnesium Hvp Chelate) + Manganese (Manganese Sulfate) + Nicotinamide + Nicotinic Acid + Potassium (Potassium Chloride) + Selenium (Selenium Hvp Chelate) + Silicon Dioxide + Vitamin a (Vitamin a Palmitate) + Vitamin B1 (Thiamine Mononitrate) + Vitamin B12 (Cyanocobalamin) + Vitamin B2 + Vitamin B6 (Pyridoxine Hydrochloride) + Vitamin C + Vitamin D (Cholecalciferol) + Vitamin E (D-Alpha Tocopheryl Acetate) + Zinc (Zinc Hvp Chelate)) |
| Indication |
Used to treat vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis. |
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Description |
Not Available |
| Pharmacology |
Vitamin D3 is a steroid hormone that has long been known for its important role in regulating body levels of calcium and phosphorus, in mineralization of bone, and for the assimilation of Vitamin A. The classical manifestations of vitamin D deficiency is rickets, which is seen in children and results in bony deformaties including bowed long bones. Deficiency in adults leads to the disease osteomalacia. Both rickets and osteomalacia reflect impaired mineralization of newly synthesized bone matrix, and usually result from a combination of inadequate exposure to sunlight and decreased dietary intake of vitamin D. Common causes of vitamin D deficiency include genetic defects in the vitamin D receptor, severe liver or kidney disease, and insufficient exposure to sunlight. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma. |
| Mechanism Of Action |
The first step involved in the activation of vitamin D3 is a 25-hydroxylation which is catalysed by the 25-hydroxylase in the liver and then by other enzymes. The mitochondrial sterol 27-hydroxylase catalyses the first reaction in the oxidation of the side chain of sterol intermediates. The active form of vitamin D3 (calcitriol) binds to intracellular receptors that then function as transcription factors to modulate gene expression. Like the receptors for other steroid hormones and thyroid hormones, the vitamin D receptor has hormone-binding and DNA-binding domains. The vitamin D receptor forms a complex with another intracellular receptor, the retinoid-X receptor, and that heterodimer is what binds to DNA. In most cases studied, the effect is to activate transcription, but situations are also known in which vitamin D suppresses transcription. Calcitriol increases the serum calcium concentrations by: increasing GI absorption of phosphorus and calcium, increasing osteoclastic resorption, and increasing distal renal tubular reabsorption of calcium. Calcitriol appears to promote intestinal absorption of calcium through binding to the vitamin D receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein. |
Vitamin D3 (Cholecalciferol) News
(When available) |
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| Dosage Forms |
CAPSULE; TABLET |
| Drug_Category |
ATC:A11CC05; Antihypocalcemic Agents; Antihypoparathyroid Agents; Essential Vitamin; Vitamins (Vitamin D) |
| Absorption |
Readily absorbed |
| Interactions |
[an error occurred while processing this directive]Toxicity |
Hypercalcemia - Early symptoms of hypercalcemia, include nausea and vomiting, weakness, headache, somnolence, dry mouth, constipation, metallic taste, muscle pain and bone pain. Late symptoms and signs of hypercalcemia, include polyuria, polydipsia, anorexia, weight loss, nocturia, conjunctivitis, pancreatitis, photophobia, rhinorrhea, pruritis, hyperthermia, decreased libido, elevated BUN, albuminuria, hypercholesterolemia, elevated ALT (SGPT) and AST (SGOT), ectopic calcification, nephrocalcinosis, hypertension and cardiac arrhythmias. |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
3-[2-[7a-methyl-1-(6-methylheptan-2-yl)-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol |
| Chemical Formula |
C27H44O |
| Molecular Weight |
384.638 g/mol |
| Smiles String |
CC(C)CCCC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C |
| Melting Point |
84.5 °C |
| Water Solubility |
Insoluble |
| State |
Solid |
| LogP/Hphobicity |
6.833 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Within the liver, cholecalciferal is hydroxylated to calcidiol (25-hydroxycholecalciferol) by the enzyme 25-hydroxylase. Within the kidney, calcidiol serves as a substrate for 1-alpha-hydroxylase, yielding calcitriol (1,25-dihydroxycholecalciferol), the biologically active form of vitamin D3. |
| Half Life |
Several weeks |
| Protein Binding [%] |
50% to 80% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0265.shtml |
| Drug Type |
Approved Drug |
| Accession No |
APRD00506 |
| CAS Registry Number |
67-97-0 |
| KEGG Compound ID |
C05443 |
| PubChem ID |
SID:7805 |
| PharmGKB ID |
PA448972 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
2242651
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