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Vitamin D2 (Ergocalciferol)
drug data and news
Vitamin D2 (Ergocalciferol) drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Vitamin D2 (Ergocalciferol) | ||
| Brand Names/Synonyms | Buco-D; Calciferol; Calciferon 2; Condacaps; Condocaps; Condol; Crtron; Crystallina; D-Arthin; D-Tracetten; Daral; Davitamon D; Davitin; De-Rat Concentrate; Decaps; Dee-Osterol; Dee-Ron; Dee-Ronal; Dee-Roual; Deltalin; Deratol; Detalup; Diactol; Divit Urto; Doral; Drisdol; Ercalciol; Ergocalciferol; Ergorone; Ergosterol Activated; Ergosterol, Irradiated; Ertron; Fortodyl; Geltabs; Hi-Deratol; Infron; Metadee; Mulsiferol; Mykostin; Novovitamin-D; Oleovitamin D; Oleovitamin D, Synthetic; Oleovitamin D2; Ostelin; Radiostol; Radstein; Radsterin; Rodine C; Shock-Ferol; Shock-Ferol Sterogyl; Sterogyl; Synthetic Vitamin D; Uvesterol-D; Vigantol; Vio-D; Viostdrol; Viosterol; Viosterol in Oil; Vitamin D; Vitamin D2; Vitavel-D | ||
| Indication | For the treament of vitamin D deficiency or insufficiency, refractory rickets (vitamin D resistant rickets), familial hypophosphatemia and hypoparathyroidism, and in the management of hypocalcemia and renal osteodystrophy in patients with chronic renal failure undergoing dialysis. Also used in conjunction with calcium in the management and prevention of primary or corticosteroid-induced osteoporosis. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Used in the treatment of hypcalcemia and in dialysis-dependent renal failure. Ergoalcifediol (Vitamin D2) is a fat soluble steroid hormone precursor of vitamin D that contributes to the maintenance of normal levels of calcium and phosphorus in the bloodstream. | ||
| Mechanism Of Action | Vitamin D2 is the form of vitamin D most commonly added to foods and nutritional supplements. Vitamin D2 must be transformed (hydroxylated) into one of two active forms via the liver or kidney. Once transformed, it binds to the vitamin D receptor that then leads to a variety of regulatory roles. Vitamin D plays an important role in maintaining calcium balance and in the regulation of parathyroid hormone (PTH). It promotes renal reabsorption of calcium, increases intestinal absorption of calcium and phosphorus, and increases calcium and phosphorus mobilization from bone to plasma. Vitamin D2 and its analogs appear to promote intestinal absorption of calcium through binding to a specific receptor in the mucosal cytoplasm of the intestine. Subsequently, calcium is absorbed through formation of a calcium-binding protein. | ||
| Vitamin D2 (Ergocalciferol) News (When available) |
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| Dosage Forms | DROPS, CAPSULES, SOLUTION, TABLETS, INJECTION | ||
| Drug_Category | ATC:A11CC01; Antihypocalcemic Agents; Antihypoparathyroid Agents; Essential Vitamin; Vitamins (Vitamin D) | ||
| Absorption | Readily absorbed from small intestine (proximal or distal), requires presence of bile salts. | ||
| Interactions | [an error occurred while processing this directive]Toxicity | Mouse, oral LD50 = 23.7 mg/kg; Rat, oral LD50 = 10 mg/kg; Nausea, vomiting and diarrhea, weight loss, irritability, weakness, fatigue, lassitude, and headache. | |
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 3-[2-[1-(5,6-dimethylhept-3-en-2-yl)-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-4-ylidene]ethylidene]-4-methylidene-cyclohexan-1-ol | ||
| Chemical Formula | C28H44O | ||
| Molecular Weight | 396.648 g/mol | ||
| Smiles String | CC(C)C(C)C=CC(C)C1CCC2C1(CCCC2=CC=C3CC(CCC3=C)O)C | ||
| Melting Point | 115.0-119.0 °C | ||
| Water Solubility | Insoluble | ||
| State | White to light yellow powder | ||
| LogP/Hphobicity | 6.388 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Within the liver, ergocalciferol is hydroxylated to ercalcidiol (25-hydroxyergocalciferol) by the enzyme 25-hydroxylase. Within the kidney, ercalcidiol serves as a substrate for 1-alpha-hydroxylase, yielding ercalcitriol (1,25-dihydroxyergocalciferol), the biologically active form of vitamin D2. | ||
| Half Life | 19 to 48 hours (however, stored in fat deposits in body for prolonged periods). | ||
| Protein Binding [%] | >99.8% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/vitamin_d_and_related_compounds.html http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0265.shtml | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00426 | ||
| CAS Registry Number | 50-14-6 | ||
| KEGG Compound ID | C05441 | ||
| PubChem ID | SID:7803 | ||
| PharmGKB ID | PA449484 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2017598 |
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