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Vitamin B12
drug data and news
Vitamin B12 drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Vitamin B12 | ||
| Brand Names/Synonyms | AIDS-001650; AIDS001650; Anacobin; B-12; B-Twelve; B-Twelve Ora; Berubigen; Betalin 12, Crystalline; Betalin-12; Betaline-12; Betolvex; Bevatine-12; Bevidox; Bevidox Concentrate; Biocobalamine; Byladoce; CN-B12; Cabadon M; Cobadoce Forte; Cobalamin; Cobalamin Concentrate; Cobalamin, Cyanide; Cobalamin, Cyano-; Cobalin; Cobamin; Cobavite; Cobione; Coobalamed; Copharvit 5000; Cosmo-Rey; Cotel; Covit; Crystamin; Crystamine; Crystimin; Crystwel; Cyano-B12; Cyanobalamin Concentrate; Cyanocobalamin; Cyanocobalamin Vitamin B12; Cyanocobalamine; Cyanocobalmin; Cycobemin; Cycolamin; Cykobemin; Cykobeminet; Cynobal; Cyomin; Cyredin; Cytacon; Cytamen; Cytobion; Depinar; Dicopac; Dimethylbenzimidazoylcobamide; Distivit; Dobetin; Docemine; Docibin; Docigram; Docivit; Dodecabee; Dodecavite; Dodex; Ducobee; Duodecibin; Embiol; Emociclina; Eritrone; Erycytol; Erythrotin; Euhaemon; Extrinsic Factor; Factor Ii; Fermin; Fresmin; Hemomin; Hepagon; Hepavis; Hepcovite; Hylugel Plus; Lactobacillus Lactis Dorner Factor; Lld Factor; Macrabin; Megabion; Megalovel; Milbedoce; Millevit; Nagravon; Normocytin; Novidroxin; Pernaemon; Pernaevit; Pernipuron; Plecyamin; Poyamin; Rebramin; Redamina; Redisol; Rhodacryst; Rubesol; Rubramin; Rubramin Pc; Rubripca; Rubrocitol; SRI 2215; Sytobex; Vi-Twel; Vibalt; Vibisone; Virubra; Vita-Rubra; Vitamin B12; Vitamin B12 Bp; Vitamin B12 Complex; Vitamin B12 Preparation; Vitamin B12b; Vitamine B12; Vitarubin; Vitral | ||
| Indication | For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Vitamin B12 is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It isneeded for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia. | ||
| Mechanism Of Action | Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells. | ||
| Vitamin B12 News (When available) |
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| Dosage Forms | Intra-nasal gel, parenteral, oral | ||
| Drug_Category | ATC:A11DB; ATC:B03BA; ATC:B03BB01; Antianemic Agents; Essential Vitamin; Vitamins (Vitamin B Complex) | ||
| Absorption | Readily absorbed in the lower half of the ileum. | ||
| Interactions |
Drug Interactions for Vitamin B12: No information provided. | ||
| Toxicity | Anaphylactic reaction (skin rash; itching; wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Not Available | ||
| Chemical Formula | C63H88CoN14O14P | ||
| Molecular Weight | 1355.37 g/mol | ||
| Smiles String | CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3] | ||
| Melting Point | > 300 °C | ||
| Water Solubility | 1.25E+004 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 3.57 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | Approximately 6 days (400 days in the liver). | ||
| Protein Binding [%] | Very high (to specific plasma proteins called transcobalamins); binding of hydroxocobalamin is slightly higher than cyanocobalamin. | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.rxlist.com/cgi/generic2/hminfr.htm http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0262.shtml | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00326 | ||
| CAS Registry Number | 68-19-9 | ||
| KEGG Compound ID | C05776 | ||
| PubChem ID | SID:597402 | ||
| PharmGKB ID | PA451892 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 715824 |
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