Vitamin B12 drug data and news

Vitamin B12 drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Vitamin B12
Brand Names/Synonyms AIDS-001650; AIDS001650; Anacobin; B-12; B-Twelve; B-Twelve Ora; Berubigen; Betalin 12, Crystalline; Betalin-12; Betaline-12; Betolvex; Bevatine-12; Bevidox; Bevidox Concentrate; Biocobalamine; Byladoce; CN-B12; Cabadon M; Cobadoce Forte; Cobalamin; Cobalamin Concentrate; Cobalamin, Cyanide; Cobalamin, Cyano-; Cobalin; Cobamin; Cobavite; Cobione; Coobalamed; Copharvit 5000; Cosmo-Rey; Cotel; Covit; Crystamin; Crystamine; Crystimin; Crystwel; Cyano-B12; Cyanobalamin Concentrate; Cyanocobalamin; Cyanocobalamin Vitamin B12; Cyanocobalamine; Cyanocobalmin; Cycobemin; Cycolamin; Cykobemin; Cykobeminet; Cynobal; Cyomin; Cyredin; Cytacon; Cytamen; Cytobion; Depinar; Dicopac; Dimethylbenzimidazoylcobamide; Distivit; Dobetin; Docemine; Docibin; Docigram; Docivit; Dodecabee; Dodecavite; Dodex; Ducobee; Duodecibin; Embiol; Emociclina; Eritrone; Erycytol; Erythrotin; Euhaemon; Extrinsic Factor; Factor Ii; Fermin; Fresmin; Hemomin; Hepagon; Hepavis; Hepcovite; Hylugel Plus; Lactobacillus Lactis Dorner Factor; Lld Factor; Macrabin; Megabion; Megalovel; Milbedoce; Millevit; Nagravon; Normocytin; Novidroxin; Pernaemon; Pernaevit; Pernipuron; Plecyamin; Poyamin; Rebramin; Redamina; Redisol; Rhodacryst; Rubesol; Rubramin; Rubramin Pc; Rubripca; Rubrocitol; SRI 2215; Sytobex; Vi-Twel; Vibalt; Vibisone; Virubra; Vita-Rubra; Vitamin B12; Vitamin B12 Bp; Vitamin B12 Complex; Vitamin B12 Preparation; Vitamin B12b; Vitamine B12; Vitarubin; Vitral
Indication For treatment of pernicious anemia (due to lack of or inhibition of intrinsic factor) and for prevention and treatment of vitamin B 12 deficiency.
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Description Not Available
Pharmacology Vitamin B12 is a water-soluble organometallic compound with a trivalent cobalt ion bound inside a corrin ring. It isneeded for nerve cells and red blood cells, and to make DNA. Vitamin B12 deficiency is the cause of several forms of anemia.
Mechanism Of Action Vitamin B12 is used in the body in two forms: Methylcobalamin and 5-deoxyadenosyl cobalamin. The enzyme methionine synthase needs methylcobalamin as a cofactor. This enzyme is involved in the conversion of the amino acid homocysteine into methionine. Methionine in turn is required for DNA methylation. 5-Deoxyadenosyl cobalamin is a cofactor needed by the enzyme that converts L-methylmalonyl-CoA to succinyl-CoA. This conversion is an important step in the extraction of energy from proteins and fats. Furthermore, succinyl CoA is necessary for the production of hemoglobin, the substances that carries oxygen in red blood cells.
Vitamin B12 News
(When available)

Keep eye on these 7 warning signals  17 May 2006
...cracked lips. The range of problems cracked lips can signal ranges from night-breathing difficulties to Vitamin B12 deficiency. And ... - Mail Tribune,

Burnbrae Farms introduces next generation omega eggs  17 May 2006
...cancer. - 50 per cent of the Recommended Daily Intake of Vitamin E. - 75 per cent of the Recommended Daily Intake of Vitamin B12. - 30 ... - Canada NewsWire (press release),

Dee Atkinson of Napiers Herbalists gives the alternative solution  May 15, 2006
Vitamin C and calcium help prevent brittleness, vitamin B12 can aid dryness and zinc prevents white spots. Solgar's Skin, Hair and Nail Formula can aid growth. - Glasgow Daily Record,

JUST TAKE ONE STEP AT A TIME  May 15, 2006
...never mind more than doubling that. You'll also need to supplement the vitamin B12 you are missing. "I hope that the outcome of ... - Glasgow Daily Record,

Repellents work sans grease, odor  May 16, 2006
If you're among those who hate using insect repellent because of its greasy feeling and odor, don't turn to dubious folk remedies like vitamin B12 or garlic ... - Indianapolis Star,

Jan De Vries: Thinning hair is a problem  May 15, 2006
A vitamin B12 preparation that he sucks one tablet of first thing in the morning and also a homeopathic preparation called Gelsemium, taken at a dose of 15 to ... - Belfast Telegraph,

Get ready for a great challenge  May 16, 2006
...those who hate using repellent because of its greasy feeling and — well, repellent — odor, don't turn to dubious folk remedies like vitamin B12 or garlic ... - The State,

High folate intake plus IVF may increase twin births  May 5, 2006
Dietary and supplemental intake of folate and vitamin B12 was calculated from self-administered food frequency questionnaires, with 528 women completing the ... - NutraIngredients.com,

Blood test expense worth it, doctor says  Apr 30, 2006
..."But it turns out nobody has used a high enough dose of vitamin B12," says Spence, who adds about 20 per cent of people over 65 have B12 deficiency and need ... - London Free Press,

Folate Overload Linked to Birth of Twins After IVF  May 5, 2006
Folate and vitamin B12 intake were assessed with a questionnaire, while plasma and red-blood-cell concentrations were measured by radioimmunoassay. ... - MedPage Today,

Excess Folic Acid Linked to More Twin Births After IVF  May 5, 2006
In a new study, researchers looked at 602 women having fertility treatment. Investigators analyzed their intake of folate and vitamin B12. ... - Ivanhoe,

Tough on crime, to hell with the causes of crime  May 9, 2006
They consumed, on average, only 63 per cent of the iron, 42 per cent of the magnesium, 39 per cent of the zinc, 39 per cent of the vitamin B12 and 34 per cent ... - Khaleej Times,

Nail the culprit  May 12, 2006
...diabetes. ~ Insufficient vitamin B12 intake may lead to dryness, very rounded and curved ends and darkening of nails. ~ Insufficient ... - Indiavarta.com,

Causes of Dementia  May 11, 2006
...form of dementia, but there are other causes such as dehydration, depression, infection, reactions to medications, or a deficiency in the vitamin B12 that can ... - KFDM-TV News,

Concern over Maori womens' diet during pregnancy  May 3, 2006
...iron and folate and high in fat and sugar, Maori women could also be lacking adequate intakes of thiamin, riboflavin, vitamin B6, vitamin B12, vitamin C ... - New Zealand Herald,

Alphabet soup: What all those vitamins will do  Apr 25, 2006
...micrograms per day. For vitamin B6, it is 1.3 to 1.7 milligrams per day. For vitamin B12, it's six micrograms per day. Vitamin C is ... - Pittsburgh Post Gazette,

Early Diagnosis as a Tool for Alzheimers disease Prevention  Apr 17, 2006
...of neurons in the brain, so the second method of Alzheimer's prevention involves taking multivitamins, such as Vitamin E, Vitamin C, Vitamin B12, and folate. ... - DailyIndia.com,

Going on a diet is bad for your foetus  May 10, 2006
...said. Parental involvement and stimulation in the first year of the child is important, as is the intake of vitamin B12 and folate. ... - Channel News Asia,

Turn me on, turn me off: a new genetic way to tackle cancer?  May 12, 2006
The most dramatic example of this process came in a 2004 study which found that by adding health-store supplements such as folic acid, vitamin B12 and choline ... - Times Online,

Starvation diets & exercise  May 7, 2006
...fuel. Deficiencies can occur that can also make you feel tired (eg iron and vitamin B12 deficiencies which can cause anaemia). The ... - Health24.com,

Newspapers Headlines 1st LD  May 13, 2006
Education Ministry to employ 7,000 teachers for 2006-2007 school year. --Health experts: Vitamin B12 deficiency disease threatens thousands of Jordanians. ... - Jordan News Agency (Petra),

A place to eat for people who can't dine on normal fare  May 11, 2006
...nausea. But it also leads to weight loss, malnutrition, such as iron and vitamin B12 deficiencies, depression and infertility. Celiac ... - Globe and Mail,

Dieting women who get pregnant put their babies at risk, says ...  May 11, 2006
Parental involvement and stimulation in the first year of the child was important, as was the intake of vitamin B12 and folate. ... - New Zealand Herald,

A distaste for milk  May 2, 2006
Nutritionally similar to cow's milk, but contains a substance that binds with vitamin B12 to stop it from being absorbed and doing us good. ... - Times Online,

Broyles unveils free ‘playbook’ for Alzheimer’s kin ...  May 13, 2006
...worth getting tested, he said, because 10 percent of cases of dementia can be cured by addressing root causes including poor sleep, vitamin B12 deficiency, or ... - Arkansas Democrat-Gazette (subscription),

Multiple Conditions Account for Mild Cognitive Impairment  May 9, 2006
Sixteen subjects had additional contributing clinical diagnoses, including trauma, vitamin B12 deficiency, Parkinson disease, depression, and alcohol abuse. ... - Medscape (subscription)

Off the menu  Apr 24, 2006
Vitamin B12 – only found in animal products – is used with iron in the delivery of oxygen and nutrients to the body's cells. ... - Courier Mail,

A Little Locker Room Juice  May 1, 2006
Cyanocobalamin is a synthetic form of Vitamin B12 that, like every self-respecting dietary supplement ingredient, has its own Web site ( http:/ / www ... - Washington Post,

Barb Troy  May 3, 2006
3rd trimesters of pregnancy. Many elderly people require a supplement of Vitamin D, Calcium and Vitamin B12. Also, to answer your ... - Milwaukee Journal Sentinel (subscription),

Health: Does 'Milk' Hurt Kids?  May 3, 2006
...feeding moms are sometimes advised to use supplements, too, since breast milk doesn't contain much D. And vegan moms' milk can be low in another vitamin, B12. ... - Standard-Speaker,

Nutrient Reference Values For Australia And New Zealand  May 5, 2006
...fats and oils. Strict vegetarians who consume no animal foods may need supplements of vitamin B12 and omega-3 fats. They will need ... - Medical News Today (press release),

Don't shun insect repellents  May 9, 2006
If you're among those who hate using repellent because of its greasy feel and odor, don't turn to dubious folk remedies like vitamin B12 or garlic, says Joe ... - Pioneer Press,

Soymilk as a healthy alternative  May 2, 2006
...now available at Reeve Union and Blackhawk Commons, have nearly as much nutrition as their dairy counterparts, providing calcium, zinc and vitamin B12, as well ... - Advance Titan,

to hell with the causes of crime if they make money  May 1, 2006
They consumed, on average, only 63% of the iron, 42% of the magnesium, 39% of the zinc, 39% of the vitamin B12 and 34% of the folate in the US government's ... - Guardian Unlimited,

Chips go to hips  Apr 20, 2006
Normally the acid pills take care of constipation and the acne. Sometimes, doctors also add vitamin B12, B complex and zinc tablets to help assimilation. ... - Hindu Business Line,

Excess Folate Boosts Chance of Twins After Assisted Reproduction  May 4, 2006
But "there was no significant association between folate and vitamin B12 intake, or blood levels, and pregnancy or rate of live births or pregnancy loss after ... - Medscape (subscription)

Biohit Oyj: Interim report of biohit group 1 january to 31 march ...  May 5, 2006
...diagnosis of upper abdominal complaints (dyspepsia), H. pylori infection, atrophic gastritis and associated risks (gastric cancer, vitamin B12 deficiency and ... - Kauppalehti (press release),

Don't forget your vitamins  Apr 25, 2006
...nutrients.". "People who are vegetarians and are not doing it well." (Many vegetarians fail to get enough vitamin B12, she said.). ... - Pittsburgh Post Gazette,

They're good for you  Apr 26, 2006
Mountain," Kemper Isely says. "She had some health problems and started taking vitamin B12 shots, which helped a lot. As she talked ... - Denver Post,

West Nile virus strikes early  Apr 26, 2006
He mentioned vitamin B12, garlic and Avon's Skin-So-Soft bath oil as substances that have been widely touted as mosquito busters but don't live up to the hype. ... - St. Louis Post-Dispatch,

Top Ten Real College Lessons  Apr 27, 2006
4. Adam Bosch taught me that being a vegan is a sin. He says that vegans don’t get enough vitamin B12 and that is why their brains don’t develop. ... - SUNY The New Paltz Oracle,

Dosage Forms Intra-nasal gel, parenteral, oral
Drug_Category ATC:A11DB; ATC:B03BA; ATC:B03BB01; Antianemic Agents; Essential Vitamin; Vitamins (Vitamin B Complex)
Absorption Readily absorbed in the lower half of the ileum.
Interactions Drug Interactions for Vitamin B12:

No information provided.

Toxicity Anaphylactic reaction (skin rash; itching; wheezing)-after parenteral administration. ORL-MUS LD50 > 8000 mg/kg
Organisms Affected Humans and other mammals
Chemical IUPAC Name Not Available
Chemical Formula C63H88CoN14O14P
Molecular Weight 1355.37 g/mol
Smiles String CC1=CC2=C(C=C1C)N(C=N2)C3C(C(C(O3)CO)OP(=O)([O-])OC(C)CNC(=O)CCC4(C(C5C6(C(C(C(=C(C7=NC(=CC8=NC(=C(C4=N5)C)C(C8(C)C)CCC(=O)N)C(C7(C)CC(=O)N)CCC(=O)N)C)[N-]6)CCC(=O)N)(C)CC(=O)N)C)CC(=O)N)C)O.[C-]#N.[Co+3]
Melting Point > 300 °C
Water Solubility 1.25E+004 mg/L
State Solid
LogP/Hphobicity 3.57
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life Approximately 6 days (400 days in the liver).
Protein Binding [%] Very high (to specific plasma proteins called transcobalamins); binding of hydroxocobalamin is slightly higher than cyanocobalamin.
RxList Link RXlist
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Drug Reference http://www.rxlist.com/cgi/generic2/hminfr.htm
http://www.pdrhealth.com/drug_info/nmdrugprofiles/nutsupdrugs/vit_0262.shtml
Drug Type Approved Drug
Accession No APRD00326
CAS Registry Number 68-19-9
KEGG Compound ID C05776
PubChem ID SID:597402
PharmGKB ID PA451892
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 715824

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