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Urokinase
drug data and news
Urokinase drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Urokinase | ||
| Brand Names/Synonyms | Urokinase-type plasminogen activator precursor;uPA;U-plasminogen activator; Abbokinase (Abbott Laboratories) | ||
| Indication | For lysis of acute pulmonary emboli | ||
| Sponsored links | Description | Low molecular weight form of human urokinase, that consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Recombinant urokinase plasminogen activator | |
| Pharmacology | Used for the treatment of pulmonary embolisms, the low molecular weight form of human urokinase consists of an A chain of 2,000 daltons linked by a sulfhydryl bond to a B chain of 30,400 daltons. Urokinase is an enzyme (protein) produced by the kidney, and found in the urine. There are two forms of urokinase which differ in molecular weight but have similar clinical effects. Abbokinase is the low molecular weight form. Abbokinase acts on the endogenous fibrinolytic system. It converts plasminogen to the enzyme plasmin. Plasmin degrades fibrin clots as well as fibrinogen and some other plasma proteins. | ||
| Mechanism Of Action | Cleaves the Arg-Val bond in plasminogen to produce active plasmin. | ||
| Urokinase News (When available) |
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| Dosage Forms | Abbokinase is supplied as a sterile lyophilized white powder containing 250,000 IU urokinase per vial, mannitol (25 mg/vial), Albumin (Human) (250 mg/vial), and sodium chloride (50 mg/vial). Following reconstitution with 5 mL of Sterile Water for Injection, USP, Abbokinase is a clear, slightly straw-colored solution; each mL contains 50,000 IU of urokinase activity, 0.5% mannitol, 5% Albumin (Human), and 1% sodium chloride (pH range 6.0 to 7.5). Abbokinase is for intravenous infusion only | ||
| Drug_Category | Thrombolytic Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Human urokinase | ||
| Chemical Formula | C1376H2145N383O406S18 | ||
| Molecular Weight | 31126.5 | ||
| Smiles String | Not Available | ||
| Melting Point | 76 oC at pH 4.5 (Nowak, U.K. et al., Biochemistry 33:2951-2960 (1994). | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.466 | ||
| Isoelectric Point | 8.66 | ||
| Biotransformation | Proteolysis | ||
| Half Life | 12 minutes. Small fractions of the administered dose are excreted in bile and urine | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Urokinase.html http://www.rxlist.com/cgi/pharmclips2.cgi?keyword=%20Abbokinase%AE | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00030 | ||
| CAS Registry Number | 9039-53-6; 99821-47-3 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA451836 | ||
| SwissProt ID | UROK_HUMAN (P00749) | ||
| GenBank ID | X02419 | ||
| Drug ID Number [DIN] | 749702 |
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