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Tubocurarine
drug data and news
Tubocurarine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Tubocurarine
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| Brand Names/Synonyms |
D-Tubocurarine; D-Tubocurarine Chloride; Delacurarine; HSDB 2152; Isoquinoline Alkaloid; Jexin; Tubarine; Tubocurarin; Tubocurarine; Tubocurarine Chloride; Tubocurarinum |
| Indication |
Used as a diagnosis agent for myasthenia gravis; Used to facilitate the intubation after induction of anesthesia in surgical procedure |
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Description |
Not Available |
| Pharmacology |
Tubocurarine, a naturally occurring alkaloid, is used to treat smoking withdrawl syndrom. |
| Mechanism Of Action |
Tubocurarine, the chief alkaloid in tobacco products, binds stereo-selectively to nicotinic-cholinergic receptors at the autonomic ganglia, in the adrenal medulla, at neuromuscular junctions, and in the brain. Two types of central nervous system effects are believed to be the basis of Tubocurarine's positively reinforcing properties. A stimulating effect is exerted mainly in the cortex via the locus ceruleus and a reward effect is exerted in the limbic system. At low doses the stimulant effects predominate while at high doses the reward effects predominate. Intermittent intravenous administration of Tubocurarine activates neurohormonal pathways, releasing acetylcholine, norepinephrine, dopamine, serotonin, vasopressin, beta-endorphin, growth hormone, and ACTH. |
Tubocurarine News
(When available) |
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| Dosage Forms |
SOLUTION |
| Drug_Category |
Neuromuscular Nondepolarizing Agents; Skeletal Muscle Relaxants; ATC:M03AA02; ATC:M03AA04 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Not Available |
| Chemical Formula |
C37H41N2O6 |
| Molecular Weight |
609.731 g/mol |
| Smiles String |
CN1CCC2=CC(=C3C=C2C1CC4=CC=C(C=C4)OC5=C6C(CC7=CC(=C(C=C7)O)O3)[N+](CCC6=CC(=C5O)OC)(C)C)OC |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
Not Available |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00176 |
| CAS Registry Number |
6989-98-6 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
SID:148848 |
| PharmGKB ID |
PA451811 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
640786
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