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Tropicamide
drug data and news
Tropicamide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Tropicamide
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| Brand Names/Synonyms |
Bistropamide; CHEMBANK1075; Epitromina; I-Picamide; Minims Tropicamide; Mydriacyl; Mydriafair; Mydriaticum; Mydrum; Ocu-Tropic; Opticyl; Paremyd; Spectro-Cyl; T167; Tropicacyl; Tropicamid; Tropicamida [Inn-Spanish]; Tropicamide; Tropicamide [Usan:Ban:Inn:Jan]; Tropicamidum [Inn-Latin]; Tropikamid; Tropimil; Visumidriatic |
| Indication |
For the treatment of acute and subacute iridocyclitis, chronic iridocyclitis, Adhesions and disruptions of iris and ciliary body, Sclera and iris operations |
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Description |
Not Available |
| Pharmacology |
Tropicamide is an ophthalmic drug that belongs to the group of medicines called anti-muscarinics. Tropicamide blocks the receptors in the muscles of the eye (muscarinic receptors). These receptors are involved controlling the pupil size and the shape of the lens. By blocking these receptors, tropicamide produces dilatation of the pupil (mydriasis) and prevents the eye from accommodating for near vision (cycloplegia). Tropicamide is given as eye drops to dilate the pupil and relax the lens so that eye examinations can be carried out thoroughly. |
| Mechanism Of Action |
Tropicamide binds to and blocks the receptors in the muscles of the eye (muscarinic receptor M4). Tropicamide acts by blocking the responses of the iris sphincter muscle to the iris and ciliary muscles to cholinergic stimulation, producing dilation of the pupil and paralysis of the ciliary muscle. |
Tropicamide News
(When available) |
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| Dosage Forms |
DROPS |
| Drug_Category |
Muscarinic Antagonists; Mydriatics; ATC:S01FA06 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Overdose can casue dry mouth, blurred vision, photophobia, hallucinations and rapid/irregular pulse |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
N-ethyl-3-hydroxy-2-phenyl-N-(pyridin-4-ylmethyl)propanamide |
| Chemical Formula |
C17H20N2O2 |
| Molecular Weight |
284.353 g/mol |
| Smiles String |
CCN(CC1=CC=NC=C1)C(=O)C(CO)C2=CC=CC=C2 |
| Melting Point |
96.5 °C |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
2.182 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
45% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Tropicamide.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00287 |
| CAS Registry Number |
1508-75-4 |
| KEGG Compound ID |
D00397 |
| PubChem ID |
SID:9392 |
| PharmGKB ID |
PA451803 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
2148536
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