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Trimethoprim
drug data and news
Trimethoprim drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Trimethoprim | ||
| Brand Names/Synonyms | Abacin; Abaprim; Alprim; Apo-Sulfatrim; BW 5672; Bactin; Bactramin; Bactrim; Bactrim Ds; Bactrim Pediatric; Baktar; Chemotrim; Co-Trimoxazole; Comox; Cotrim; Cotrim D.S.; Drylin; Eusaprim; Fectrim; Gantaprim; Gantrim; Idotrim; Imexim; Instalac; Ipral; Kepinol; Laratrim; Lidaprim; Linaris; Methoprim; Microtrim; Monoprim; Monotrim; Monotrimin; NIH 204; Nopil; Oraprim; Priloprim; Primosept; Primsol; Proloprim; Septra; Septra Ds; Septra Grape; Septrin; Sigaprim; Sulfamethoprim; Sulfamethoprim-Ds; Sulfamethoxazole & Trimethoprim; Sulfatrim; Sulfatrim Pediatric; Sulfatrim-Ds; Sulfatrim-Ss; Sulfotrim; Sulmeprim; Sulmeprim Pediatric; Sulprim; Sumetrolim; Supracombin; Suprim; Syraprim; TRIMETHOPRIM; Teleprim; Thiocuran; Tiempe; Tmp-Ratiopharm; Trigonyl; Trimanyl; Trimesulf; Trimeth/Sulfa; Trimethioprim; Trimethopriom; Trimetoprim; Trimexazole; Trimogal; Trimopan; Trimpex; Trimpex 200; Triprim; Unitrim; Uretrim; Uro-Septra; Uroplus; Uroplus Ds; Uroplus Ss; Veltrim; Wellcoprim | ||
| Indication | For the treatment of initial episodes of uncomplicated urinary tract infections | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Trimethoprim, a synthetic antiinfective agent, is used to treat and prevent urinary tract infections, diarrhea, and, when combined with either sulfamethoxazole or dapsone, Pneumocystis carinii infections. | ||
| Mechanism Of Action | Trimethoprim binds to bacterial dihydrofolate reductase, subsequently interfering with the uptake of p-aminobenzoic acid (PABA) into folic acid. As folic acid is a coenzyme responsible for the transport of one-carbon fragments from one molecule to another, it is an essential component of bacterial development. Sulfonamides inhibit bacterial dihydrofolate synthetase, the enzyme immediately preceding dihydrofolate reductase, and therefore act synergistically with trimethoprim. | ||
| Trimethoprim News (When available) |
Trimethoprim-Sulfamethoxazole Effective in Community-acquired MRSA ... May 10, 2006 BAY AREA Don't dump old medicine in toilet May 11, 2006 O1 isolation enhanced with antibiotic selection technique Apr 27, 2006 Boils and bats and bacteria... Oh my! Infectious disease ... May 2, 2006 View larger version (35K): May 3, 2006 | ||
| Dosage Forms | TABLET | ||
| Drug_Category | Antimalarials; Anti-Infectives; Anti-Infectives; ATC:J01EA01 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Trimethoprim: Trimethoprim may inhibit the hepatic metabolism of phenytoin. Trimethoprim, given at a common clinical dosage, increased the phenytoin half-life by 51% and decreased the phenytoin metabolic clearance rate by 30%. When administering these drugs concurrently, one should be alert for possible excessive phenytoin effect. | ||
| Toxicity | LD50=4850 (orally in mice) | ||
| Organisms Affected | Not Available | ||
| Chemical IUPAC Name | 5-[(3,4,5-trimethoxyphenyl)methyl]pyrimidine-2,4-diamine | ||
| Chemical Formula | C14H18N4O3 | ||
| Molecular Weight | 290.318 g/mol | ||
| Smiles String | COC1=CC(=CC(=C1OC)OC)CC2=CN=C(N=C2N)N | ||
| Melting Point | 199 - 203 °C | ||
| Water Solubility | 12.1 mg/mL | ||
| State | Solid | ||
| LogP/Hphobicity | 1.364 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 8-10 hours | ||
| Protein Binding [%] | ~45% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Trimethoprim.html http://www.rxlist.com/cgi/generic2/trimeth.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00103 | ||
| CAS Registry Number | 738-70-5 | ||
| KEGG Compound ID | C01965 | ||
| PubChem ID | SID:156267 | ||
| PharmGKB ID | PA451788 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2243116 |
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