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Trimethaphan
drug data and news
Trimethaphan drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Trimethaphan
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| Brand Names/Synonyms |
Arfonad; TRIMETHAPHAN; Thimethaphan; Trimetaphan; Trimetaphanum; Trimethaphan |
| Indication |
For the controlled reduction of blood pressure during surgery and in the treatment of hypertensive emergencies. |
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Description |
Not Available |
| Pharmacology |
Trimethaphan is indicated for production of controlled hypotension during surgery to reduce bleeding into the surgical field and also for rapid reduction of blood pressure in the treatment of hypertensive emergencies, especially in patients with acute dissecting aneurysm, and in the emergency treatment of pulmonary edema in patients with pulmonary hypertension associated with systemic hypertension. |
| Mechanism Of Action |
Trimethaphan is a ganglionic blocking agent prevents stimulation of postsynaptic receptors by competing with acetylcholine for these receptor sites. Additional effects may include direct peripheral vasodilation and release of histamine. Trimethaphan's hypotensive effect is due to reduction in sympathetic tone and vasodilation, and is primarily postural. |
Trimethaphan News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Antihypertensive Agents; Vasodilator Agents; ATC:C02BA01 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
1,1,2,2,2-pentadeuterioethanamine |
| Chemical Formula |
C22H25N2OS |
| Molecular Weight |
365.513 g/mol |
| Smiles String |
C1CC2C3C(C[S+]2C1)N(C(=O)N3CC4=CC=CC=C4)CC5=CC=CC=C5 |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
Not Available |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00044 |
| CAS Registry Number |
7187-66-8 |
| KEGG Compound ID |
C07174 |
| PubChem ID |
CID:23576 |
| PharmGKB ID |
PA451784 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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