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Trimeprazine
drug data and news
Trimeprazine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Trimeprazine
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| Brand Names/Synonyms |
Alimemazina [Inn-Spanish]; Alimemazine; Alimemazinum [Inn-Latin]; Alimezine; Bayer 1219; CHEMBANK2440; Dl-Trimeprazine; HSDB 3197; Levoprome; Methylpromazine; Panectyl; RP 6549; Repeltin; Repetin; Temaril; Teralen; Theralene; Trimeperazine; Trimeprazine; Trimeprazine Tartrat; Trimeprazine Tartrate |
| Indication |
For the treatment of allergic symptoms arising from hay fever including pruritus, urticaria and allergy |
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Description |
Not Available |
| Pharmacology |
Trimeprazine is a tricyclic antihistamine, similar in structure to the phenothiazine antipsychotics, but differing in the ring-substitution and chain characteristics. Trimeprazine is in the same class of drugs as chlorpromazine (Thorazine) and trifluoperazine (Stelazine); however, unlike the other drugs in this class, Trimeprazine is not used clinically as an anti-psychotic. It acts as an anti-histamine, a sedative, and an anti-emetic (anti-nausea). Trimeprazine is used principally as an anti-emetic, to prevent motion sickness or as an anti-histamine in combination with other medications in cough and cold preparations. Tricyclic antihistamines are also structurally-related to the tricyclic antidepressants, explaining the antihistaminergic adverse effects of these two drug classes and also the poor tolerability profile of tricyclic H1-antihistamines. |
| Mechanism Of Action |
Trimeprazine competes with free histamine for binding at HA-receptor sites. This antagonizes the effects of histamine on HA-receptors, leading to a reduction of the negative symptoms brought on by histamine HA-receptor binding. |
Trimeprazine News
(When available) |
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| Dosage Forms |
TABLET ; LIQUID |
| Drug_Category |
Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine |
| Chemical Formula |
C18H22N2S |
| Molecular Weight |
298.447 g/mol |
| Smiles String |
CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)CN(C)C |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
5.162 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Trimeprazine.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00258 |
| CAS Registry Number |
4330-99-8 |
| KEGG Compound ID |
D02245 |
| PubChem ID |
SID:149788 |
| PharmGKB ID |
PA451781 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
1926292
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