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Trifluoperazine
drug data and news
Trifluoperazine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Trifluoperazine | ||
| Brand Names/Synonyms | Apo-Trifluoperazine; Eskazine; Eskazinyl; Fluoperazine; Jatroneural; Modalina; Novo-Trifluzine; Pms Trifluoperazine; RP 7623; SKF 5019; Stelazine; Stelazine Concentrate; Stellazine; Synklor; Terfluzine; Trazine; Trifluoperazin; Trifluoperazina; Trifluoperazine; Trifluoperazine Dihydrochloride; Trifluoperazine Hcl; Trifluoperazine Hydrochloride; Trifluoromethylperazine; Trifluoroperazine; Trifluoroperazine Dihydrochloride; Trifluoroperazine Hydrochloride; Trifluperazine; Triflurin; Trifluroperizine; Triftazin; Triftazine; Triperazine; Triphtazin; Triphtazine; Triphthasine; Triphthazine; Triphthazine Dihydrochloride; Tryptazine; Tryptazine Dihydrochloride | ||
| Indication | For the treatment of anxiety disorders, depressive symptoms secondary to anxiety and agitation | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Trifluoperazine is a trifluoro-methyl phenothiazine derivative intended for the management of schizophrenia and other psychotic disorders. Trifluoperazine has not been shown effective in the management of behaviorial complications in patients with mental retardation. | ||
| Mechanism Of Action | Trifluoperazine blocks postsynaptic mesolimbic dopaminergic D1 and D2 receptors in the brain; depresses the release of hypothalamic and hypophyseal hormones and is believed to depress the reticular activating system thus affecting basal metabolism, body temperature, wakefulness, vasomotor tone, and emesis. | ||
| Trifluoperazine News (When available) |
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| Dosage Forms | SYRUP | ||
| Drug_Category | Antipsychotics; Antiemetics; Phenothiazines; ATC:N05AB06 | ||
| Absorption | Not Available | ||
| Interactions |
-->Interactions for Trifluoperazine: No information provided.
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| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 10-[3-(4-methylpiperazin-1-yl)propyl]-2-(trifluoromethyl)-10H-phenothiazine | ||
| Chemical Formula | C21H24F3N3S | ||
| Molecular Weight | 407.497 g/mol | ||
| Smiles String | CN1CCN(CC1)CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)C(F)(F)F | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 5.366 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Trifluoperazine.html http://www.rxlist.com/cgi/generic3/trifluo.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00173 | ||
| CAS Registry Number | 117-89-5 | ||
| KEGG Compound ID | C07168 | ||
| PubChem ID | SID:9377 | ||
| PharmGKB ID | PA451771 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 776505 |
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