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Trichlormethiazide
drug data and news
Trichlormethiazide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Trichlormethiazide
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| Brand Names/Synonyms |
Achletin; Anatran; Anistadin; Aponorin; Carvacron; Chlopolidine; Cretonin; Diu-Hydrin; Diurazida; Diurese; Diuroral; Esmarin; Eurinol; Fluitran; Flurese; Flutra; Gangesol; Hydrotrichlorothiazide; Intromene; Isestran; Kubacron; Metahydrin; Metatensin; Metatensin #2; Metatensin #4; Nakva; Naqua; Naquasone; Naquival; Salurin; Schebitran; Tachionin; Tolcasone; Trichlorex; Trichlormas; Trichlormetazid; Trichlormethiazid; Trichlormethiazide; Trichlormethiazide W/ Reserpine; Trichloromethiadiazide; Trichloromethiazide; Triclordiuride; Triclormetiazide; Triflumen |
| Indication |
Used in the treatment of oedema (including that associated with heart failure) and hypertension. |
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Description |
Not Available |
| Pharmacology |
Trichloromethiazide is indicated as adjunctive therapy in edema associated with congestive heart failure, hepatic cirrhosis, and corticosteroid and estrogen therapy. Trichloromethiazide has also been found useful in edema due to various forms of renal dysfunction such as nephrotic syndrome, acute glomer-ulonephritis, and chronic renal failure. Trichloromethiazide is also indicated in the management of hypertension either as the sole therapeutic agent or to enhance the effectiveness of other antihypertensive drugs in the more severe forms of hypertension. Like other thiazides, Trichloromethiazide promotes water loss from the body (diuretics). They inhibit Na+/Cl- reabsorption from the distal convoluted tubules in the kidneys. Thiazides also cause loss of potassium and an increase in serum uric acid. Thiazides are often used to treat hypertension, but their hypotensive effects are not necessarily due to their diuretic activity. Thiazides have been shown to prevent hypertension-related morbidity and mortality although the mechanism is not fully understood. Thiazides cause vasodilation by activating calcium-activated potassium channels (large conductance) in vascular smooth muscles and inhibiting various carbonic anhydrases in vascular tissue. |
| Mechanism Of Action |
Trichlormethiazide appears to block the active reabsorption of chloride and possibly sodium in the ascending loop of Henle, altering electrolyte transfer in the proximal tubule. This results in excretion of sodium, chloride, and water and, hence, diuresis. As a diuretic, Trichloromethiazide inhibits active chloride reabsorption at the early distal tubule via the Na-Cl cotransporter, resulting in an increase in the excretion of sodium, chloride, and water. Thiazides like Trichloromethiazide also inhibit sodium ion transport across the renal tubular epithelium through binding to the thiazide sensitive sodium-chloride transporter. This results in an increase in potassium excretion via the sodium-potassium exchange mechanism. The antihypertensive mechanism of Trichloromethiazide is less well understood although it may be mediated through its action on carbonic anhydrases in the smooth muscle or through its action on the large-conductance calcium-activated potassium (KCa) channel, also found in the smooth muscle. |
Trichlormethiazide News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Diuretics; Antihypertensive Agents; ATC:C03AA06 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Oral Rat LD50 = 5600 mg/kg Oral Mouse LD50 = 2600 mg/kg |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
3-chloro-9-(dichloromethyl)-7,7-dioxo-7$l^{6}-thia-8,10-diazabicyclo[4.4.0]deca-1,3,5-triene-4-sulfonamide |
| Chemical Formula |
C8H8Cl3N3O4S2 |
| Molecular Weight |
380.657 g/mol |
| Smiles String |
C1=C2C(=CC(=C1Cl)S(=O)(=O)N)S(=O)(=O)NC(N2)C(Cl)Cl |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
1.023 |
| Isoelectric Point |
8.6 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Trichlormethiazide.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00031 |
| CAS Registry Number |
133-67-5 |
| KEGG Compound ID |
C07767 |
| PubChem ID |
SID:9969 |
| PharmGKB ID |
PA451754 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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