Triamcinolone drug data and news

Triamcinolone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Triamcinolone

Brand Names/Synonyms

Adcortyl; Aristocort; Aristocort A; Aristocort Tablets; Aristogel; Aristospan; Azmacort; CL 19823; Celeste; Cinolone; Cinolone-T; Delphicort; Fluoxiprednisolone; Fluoxyprednisolone; Flutex; HSDB 3194; Kenacort; Kenacort-A; Kenacort-Ag; Kenalog; Kenalog in Orabase; Kenalog-10; Kenalog-40; Kenalog-H; Ledercort; Nasacort; Nasacort Aq; Nasacort Hfa; Omcilon; Omicilon; Oracort; Oralone; Orion; Polcortolon; Rodinolone; Sk-Triamcinolone; Tiamcinolonum [Inn-Latin]; Tri-Nasal; Triacet; Triacort; Triam-Tablinen; Triamcet; Triamcinalone; Triamcinlon; Triamcinolon; Triamcinolona [Inn-Spanish]; Triamcinolone; Triamcinolone Acetonide; Triamcinolone Acetonide in Absorbase; Triamcinolone Diacetate; Triamcinolone [Usan:Ban:Inn:Jan]; Triamcinolonum [Inn]; Triatex; Tricortale; Triderm; Trymex; Vetalog; Volon

Indication

For the treatment of perennial and seasonal allergic rhinitis

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Description

Not Available

Pharmacology

Triamcinolone and its derivatives are synthetic glucocorticoids that are used for their antiinflammatory or immunosuppressive properties.

Mechanism Of Action

The antiinflammatory actions of corticosteroids are thought to involve lipocortins, phospholipase A2 inhibitory proteins which, through inhibition of arachidonic acid, control the biosynthesis of prostaglandins and leukotrienes. The immune system is suppressed by corticosteroids due to a decrease in the function of the lymphatic system, a reduction in immunoglobulin and complement concentrations, the precipitation of lymphocytopenia, and interference with antigen-antibody binding.

Triamcinolone News
(When available)

Barr Confirms Patent Challenge of NASACORT(R) AQ Nasal Spray May 4, 2006
..., today announced that it is challenging the patents protecting Aventis Pharmaceuticals, Inc.'s NASACORT(R) AQ (Triamcinolone Acetonide) Nasal Spray. ... - Finanzen.net,

Triple Regimen Safe and Effective for Choroidal Neovascularization ... May 2, 2006
FL -- May 2, 2006 -- A small study has found that patients who receive triple therapy with a combination of intravitreal triamcinolone, photodynamic therapy ... - DG News

Ethnic Skin: A Spectrum of Issues Apr 19, 2006
...no definitive treatment options. [16] A mainstay of treatment is intralesional triamcinolone (10-40 mg/mL). Injections are given ... - Medscape (subscription)

Shinn out for 20 meetings May 1, 2006
Flemington trainer Robert Smerdon was yesterday fined $4000 after his sprinter Jestajewel proved positive to Triamcinolone Acetonid — a corticosteroid and ... - The Age,

Barr seeks approval for generic Nasacort - challenges patents May 5, 2006
Nasacort AQ (triamcinolone acetonide) nasal spray is specifically indicated for the treatment of the nasal symptoms of seasonal and perennial allergic rhinitis ... - Pharmaceutical Business Review

Springtime allergies: Solutions for a problem in full bloom May 5, 2006
...symptoms. Examples include fluticasone propionate (Flonase), budesonide (Rhinocort), mometasone (Nasonex) and triamcinolone (Nasacort). ... - MayoClinic.com

Sanofi sales advance despite generic competition May 5, 2006
Meantime, US generics company Barr Laboratories has said it is challenging Sanofi-Aventis' US patents on Nasacort AQ nasal spray (triamcinolone acetonide), a ... - Pharma Times (subscription),

Smerdon fined over swab May 1, 2006
...the three year old, who finished last of five to Jestawinna in the Mike North Sales Handicap on November 18, was found to contain triamcinolone acetonide, a ... - FOX SPORTS,

Dosage Forms

CREAM; LIQUID; METERED-DOSE (AEROSOL); OINTMENT; PASTE; SUSPENSION; SYRUP; TABLET

Drug_Category

Glucocorticoids; Anti-inflammatory Agents; Adrenergic Agents; ATC:A01AC01; ATC:D07AB09; ATC:D07XB02; ATC:H02AB08; ATC:R01AD11; ATC:R03BA06; ATC:S01BA05

Absorption

Rapid absorption following oral administration

Interactions

Not Available

Toxicity

LD50:(Rat) >500mg/kg

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

9-fluoro-11,16,17-trihydroxy-17-(2-hydroxyacetyl)-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-3-one

Chemical Formula

C21H27FO6

Molecular Weight

394.434 g/mol

Smiles String

CC12CC(C3(C(C1CC(C2(C(=O)CO)O)O)CCC4=CC(=O)C=CC43C)F)O

Melting Point

274 - 278 (dec) °C

Water Solubility

80 mg/L

State

Solid

LogP/Hphobicity

0.329

Isoelectric Point

Not Available

Biotransformation

Not Available

Half Life

88 minutes

Protein Binding [%]

68%

RxList Link

RXlist

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Drug Reference

http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/azm1044.shtml
http://www.drugs.com/cons/Triamcinolone.html
http://www.rxlist.com/cgi/generic/triamaer.htm

Drug Type

Approved Drug

Accession No

APRD00422

CAS Registry Number

124-94-7

KEGG Compound ID

C07158

PubChem ID

SID:173366

PharmGKB ID

PA451748

SwissProt ID

Not Available

GenBank ID

Not Available

Drug ID Number [DIN]

2229540