Trazodone drug data and news

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Mechanic jailed for date rape of lap-dancer  17 May 2006
Tests on an opened bottle of Spanish champagne found in the flat revealed traces of a drug Trazodone, a prescription-only sedative used to treat depression and ... - Scotsman,

Policies on mentally troubled troops questioned  17 May 2006
...doctors about a lack of psychotropic drugs, which prompted the military to approve making antidepressants, including Prozac, Zoloft and trazodone, more widely ... - Baltimore Sun,

Op-Ed Contributor Generic Smear Campaign  May 10, 2006
Yet many people have never heard of one of the most widely prescribed hypnotics in the United States: trazodone. First approved ... - New York Times,

Drug Makers Pay Doctors To Write Studies Criticizing Generic Drugs ...  May 9, 2006
...such as Sepracor's Lunesta and Sanofi Aventis' Ambien, have made the medications "household names," but "most people have never heard of" trazodone, a widely ... - Kaiser network.org,

Clubber denies raping lapdancer after she was drugged  May 11, 2006
...that he raped her at a flat in Dalry, Edinburgh, while the woman was unconscious, under the influence of alcohol "and the drug known as Trazodone, which had ... - Scotsman,

Patient Management Exercise FOR PSYCHOTHERAPY  May 15, 2006
To treat his depression, he was given fluoxetine, titrated to 40 mg by the end of his stay. He was also started on 100 mg of trazodone at bedtime for insomnia. ... - Focus (subscription)

No More Counting Sheep  May 3, 2006
...function. Originally used as an antidepressant, Trazodone is one of the most popular sleep-aids, according to Consumer Health Digest. ... - University Daily Kansan,

Innovations: Geriatric Psychiatry: Diagnosis and Treatment of ...  May 10, 2006
Trazodone, citalopram, other serotonergic medications, and anticonvulsants are effective and well tolerated when prescribed to treat agitated behavior of ... - Psychiatric Services (subscription)

District Court Report  May 10, 2006
...of class A drug (heroin), possession of class B drug (cocaine), possession of class B drug (seboxyn), possession of class E drug (trazodone): state declined to ... - Martha's Vineyard Times,

To Understand Depression, Look to Psychobiology, Not Biopsychiatry  Apr 28, 2006
...room late one evening to evaluate a 50-year-old man who had taken an overdose of his antidepressant medications mirtazapine (Remeron) and trazodone (Desyrel). ... - Psychiatric Times,

For Katrina evacuee, a life still adrift  May 7, 2006
He was released with a prescription for the antidepressant Trazodone and an appointment for a follow-up at Community Counseling in January. ... - Boston Globe,

District Court  May 6, 2006
...of cocaine with intent to distribute, a count of possession of cocaine, a count of possession of marijuana, a count of possession of trazodone, along with ... - North Adams Transcript,

Sepracor Announces First Quarter 2006 Results  Apr 25, 2006
...the most commonly used previoustherapies were AMBIEN(R) brand zolpidem tartrate, other prescriptioninsomnia medications, and trazodone, an antidepressant ... - Finanzen.net,

Sepracor Announces First Quarter 2006 Results  Apr 25, 2006
...the most commonly used previous therapies were AMBIEN(R) brand zolpidem tartrate, other prescription insomnia medications, and trazodone, an antidepressant ... - Genetic Engineering News,

Update on the Antidepressant Controversy  Apr 17, 2006
The older antidepressants, primarily tricyclics and trazodone, were associated with a higher risk of suicidality in the first month of treatment; this was not ... - Psychiatric Times,

Labopharm reports results for first quarter fiscal 2006  Apr 25, 2006
The increase was also the result of costs related to the pharmacokinetic study for the Company's once-daily trazodone product that was conducted in the first ... - Yahoo! News (press release)

Physicians Accused of Aiding, Profiting From Drug Abusers  Apr 23, 2006
...traumatic stress disorder and giving them prescriptions for the anti- anxiety medications Klonopin and Xanax and the antidepressant Trazodone, records show. ... - International News Service,

In vitro drug metabolism studies suggest that there is a potential for drug interactions when trazodone is given with CYP3A4 inhibitors. Ritonavir, a potent CYP3A4 inhibitor, increased the C_max, AUC, and elimination half- life, and decreased clearance of trazodone after administration of ritonavir twice daily for 2 days. Adverse effects including nausea, hypotension, and syncope were observed when ritonavir and trazodone were coadministered. It is likely that ketoconazole, indinavir, and other CYP3A4 inhibitors such as itraconazole or nefazodone may lead to substantial increases in trazodone plasma concentrations, with the potential for adverse effects. If trazodone is used with a potent CYP3A4 inhibitor, a lower dose of trazodone should be considered.

Carbamazepine reduced plasma concentrations of trazodone when co-administered. Patients should be closely monitored to see if there is a need for an increased dose of trazodone when taking both drugs.

Increased serum digoxin or phenytoin levels have been reported to occur in patients receiving DESYREL concurrently with either of those two drugs.

It is not known whether interactions will occur between mono-amine oxidase (MAO) inhibitors and DESYREL. Due to the absence of clinical experience, if MAO inhibitors are discontinued shortly before or are to be given concomitantly with DESYREL, therapy should be initiated cautiously with gradual increase in dosage until optimum response is achieved.

Therapeutic Interactions

Concurrent administration with electroshock therapy should be avoided because of the absence of experience in this area.

There have been reports of increased and decreased prothrombin time occurring in warfarinized patients who take DESYREL.