|
![]() |
|
|
Trastuzumab
drug data and news
Trastuzumab drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Trastuzumab | ||
| Brand Names/Synonyms | Ig gamma-1 chain C region; Herceptin; Anti HER2; Herceptin (Genentech) | ||
| Indication | For treatment of HER2-positive metatsatic breast cancer | ||
| Sponsored links | Description | A recombinant IgG1 kappa, humanized monoclonal antibody that selectively binds with high affinity in a cell-based assay (Kd = 5 nM) to the extracellular domain of the human epidermal growth factor receptor protein. Produced in CHO cell culture. | |
| Pharmacology | Used in the treatment of HER2-positive breast cancer. HER2 protein overexpression is observed in 25%-30% of primary breast cancers.Trastuzumab has been shown, in both in vitro assays and in animals, to inhibit the proliferation of human tumorcells that overexpress HER2. It is a mediator of antibody dependent cellular cytotoxicity, in that the binding of the antibody to HER2 overexpressing cells leads to preferential cell death. | ||
| Mechanism Of Action | Trastuzumab binds to the HER2 (or c-erbB2) proto-oncogene, an EGF receptor-like protein found on 20-30% of breast cancer cells. The binding leads to antibody mediated (complement mediated) killing of the HER2 positive cells. | ||
| Trastuzumab News (When available) |
Herceptin® Plus Doxil® Safe and Effective in Metastatic Breast ... 17 May 2006 ImmunoGen Agrees To Create Commercial Manufacturing Process For ... May 4, 2006 ImmunoGen to Develop Manufacturing Process for Trastuzumab-DM1 for ... May 8, 2006 DRUGS IN DEVELOPMENT May 4, 2006 Genentech Announces Vice President Appointments in Commercial ... May 11, 2006 Gene amplification could guide treatment for high-risk breast ... May 11, 2006 ��:生命�纬 Apr 28, 2006 Kosan Announces Clinical Data to be Presented at the 2006 Annual ... May 8, 2006 Herceptin Receives Positive Opinion in Europe for Early Use in ... Apr 28, 2006 ImmunoGen, Inc. Reports Third Quarter Fiscal Year 2006 Financial ... May 4, 2006 Intrathecal Herceptin® May Halt Cancer Progression Within the ... Apr 24, 2006 Herceptin Receives Positive Opinion in Europe for Early Use in ... Apr 27, 2006 Researchers detail new studies and findings in the area of breast ... Apr 20, 2006 COMUNICADO: Herceptin Receives Positive Opinion in Europe for ... Apr 27, 2006 ImmunoGen Shares Rise on Genentech Deal May 4, 2006 Study provides data for price-setting policies related to ... Apr 20, 2006 Breast cancer fine needle aspiration cytology specimens contain ... May 4, 2006 Herceptin® May Change the Natural History of Patients with HER2 ... May 1, 2006 Additional Evidence that Herceptin® Benefits Women with HER2 ... Apr 17, 2006 New hope on breast cancer drug Apr 18, 2006 Australia's medicines regulator close to decision on herceptin Apr 20, 2006 ImmunoGen, Inc. Announces Conference Call to Discuss its Third ... Apr 27, 2006 Collaboration Can Advance Pharmacogenomics Apr 17, 2006 Herceptin wins record EU nod for early breast cancer Apr 28, 2006 Taxotere®, Platinol®, and Herceptin® for Locally Advanced HER2 ... Apr 24, 2006 | ||
| Dosage Forms | Not Available | ||
| Drug_Category | Antineoplastic Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Humanized anti-HER2 antibody | ||
| Chemical Formula | C6470H10012N1726O2013S42 >Anti-HER2 Heavy chain 1 >Anti-HER2 Light chain 2 >Anti-HER2 Heavy chain 2 | ||
| Molecular Weight | 145531.5 | ||
| Smiles String | Not Available | ||
| Melting Point | 61 oC (FAB fragment), 71 oC (whole mAb)-Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.415 | ||
| Isoelectric Point | 8.45 | ||
| Biotransformation | Most likely removed by opsonization via the reticuloendothelial system. | ||
| Half Life | 2-12 days | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Trastuzumab.html http://www.rxlist.com/cgi/generic/trastuz.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00098 | ||
| CAS Registry Number | 180288-69-1 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:736684 | ||
| PharmGKB ID | PA451743 | ||
| SwissProt ID | IGHG1_HUMAN (P01857) | ||
| GenBank ID | J00228 | ||
| Drug ID Number [DIN] | Not Available |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |