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Tolazoline
drug data and news
Tolazoline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Tolazoline
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| Brand Names/Synonyms |
Artonil; Benzazoline; Benzidazol; Benzolin; Benzylimidazoline; CIBA 3259; Dilatol Asi; Divascol; Imidalin; Imidaline; Kasimid; Lambril; None; Olitensol; Peripherine; Phenylmethylimidazoline; Prefaxil; Priscol; Priscoline; Tolazolin; Tolazoline; Vasimid; Vasodil; Vasodilatan |
| Indication |
For the treatment of pulmonary artery anomalies |
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Description |
Not Available |
| Pharmacology |
Tolazoline is a pulmonary vasodilator indicated used to decrease pulmonary vascular resistance (PVR) in persistent pulmonary hypertension of the newborn (PPHN). |
| Mechanism Of Action |
Vasodilation by means of a direct effect on peripheral vascular smooth muscle and indirect effects produced, in part, by release of endogenous histamine; tolazoline has moderate alpha-adrenergic blocking activity and has histamine agonist activity. Tolazoline usually reduces pulmonary arterial pressure and vascular resistance. |
Tolazoline News
(When available) |
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| Dosage Forms |
LIQUID |
| Drug_Category |
Vasodilator Agents; Antihypertensive Agents; ATC:C04AB02; ATC:M02AX02 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-benzyl-4,5-dihydro-1H-imidazole |
| Chemical Formula |
C10H12N2 |
| Molecular Weight |
160.216 g/mol |
| Smiles String |
C1CN=C(N1)CC2=CC=CC=C2 |
| Melting Point |
174 °C |
| Water Solubility |
373 mg/L |
| State |
Solid |
| LogP/Hphobicity |
1.205 |
| Isoelectric Point |
10.3 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00170 |
| CAS Registry Number |
59-98-3 |
| KEGG Compound ID |
C07147 |
| PubChem ID |
SID:9356 |
| PharmGKB ID |
PA451716 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
2195887
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