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Thyrotropin Alfa
drug data and news
Thyrotropin Alfa drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Thyrotropin Alfa | ||
| Brand Names/Synonyms | Follitropin beta chain precursor;Follicle-stimulating hormone beta subunit;FSH-beta;FSH-B; Thyrogen (Genzyme Inc) | ||
| Indication | For detection of residueal or recurrent thyroid cancer | ||
| Sponsored links | Description | Thyrotropin alfa is a heterodimeric glycoprotein comprised of two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone. | |
| Pharmacology | Binding of thyrotropin alfa to TSH receptors on normal thyroid epithelial cells or on well-differentiated thyroid cancer tissue stimulates iodine uptake and organification. Thyrogen is an exogenous source of human TSH that offers an additional diagnostic tool in the follow-up of patients with a history of well-differentiated thyroid cancer. | ||
| Mechanism Of Action | Binds to the thyrotropin receptors found on any residual thyroid cells or tissues. This stimulates radioactive iodine uptake for better radiodiagnostic imaging. | ||
| Thyrotropin Alfa News (When available) |
Genzyme Reports Financial Results for the First Quarter of 2006 Apr 19, 2006 | ||
| Dosage Forms | POWDER FOR SOLUTION | ||
| Drug_Category | Diagnostic Agents; thyroid function (36:60.00) | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Human alpha thyrotropin | ||
| Chemical Formula | C975H1513N267O304S26 >beta chain | ||
| Molecular Weight | 22672.9 | ||
| Smiles String | Not Available | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.33 | ||
| Isoelectric Point | 7.5 | ||
| Biotransformation | Not Available | ||
| Half Life | 5 +/- 10 hrs | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.rxlist.com/cgi/generic2/thyrotropin.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00020 | ||
| CAS Registry Number | 9002-71-5 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA451681 | ||
| SwissProt ID | FSHB_HUMAN (P01225) | ||
| GenBank ID | M16647 | ||
| Drug ID Number [DIN] | 2246016 |
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