Thiopental drug data and news

Thiopental drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Thiopental
Brand Names/Synonyms Dea No. 2100; Farmotal; Intraval; Nesdonal; Penthiobarbital; Pentothal; Pentothiobarbital; Robinax; Thiomebumal; Thionembutal; Thiopental; Thiopentobarbital; Thiopentobarbitone; Thiopentobarbituric Acid; Thiopentone; Thiothal; Tiopentale; Tiopentale [Italian]; Trapanal
Indication Intravenous anaesthetic
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Description Not Available
Pharmacology Thiopental, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation.
Mechanism Of Action Thiopental binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged.
Thiopental News
(When available)

Fog over executions could clear today  16 May 2006
The central argument about the lethal three drug-cocktail focuses upon the effectiveness of the initial anesthetic — sodium thiopental, a short-acting ... - Houston Chronicle,

Lethal injection challenge  May 8, 2006
...unconsciousness are achieved and continue for the duration of the execution before administering painful drugs; and 4) dispenses a dose of Thiopental that is ... - Arkansas Times,

“Botched executionsâ€? findings expose grisly practice US: Legal ...  May 9, 2006
Three drugs are then injected into the line by executioners hidden from view: an anesthetic (sodium thiopental), followed by a paralytic agent (pancuronium ... - World Socialist Web Site,

How Does It Feel?  May 3, 2006
In Missouri as in most states, lethal injection is a three-step process: The anesthetic sodium thiopental (sodium pentothal) is administered, followed by ... - Riverfront Times,

Challenges slow US executions  Apr 23, 2006
Under the lethal injection protocol used in most states, an inmate is first given sodium thiopental, an anaesthesia designed to render him unconscious. ... - Reno Gazette Journal,

Cruel punishment of lethal injection  Apr 18, 2006
Three drugs are used in the lethal injection procedure. The first chemical, sodium thiopental, is a barbiturate used to sedate an inmate. ... - Socialist Worker Online,

Lethal injection a cruel death?  May 7, 2006
Tennessee's three-drug protocol is similar to that of other states: The first drug administered, sodium pentothal, or thiopental, is meant to deaden the pain. ... - The Tennessean,

Doctors and Lethal Injection  Apr 20, 2006
The first drug administered in this procedure is the barbiturate sodium thiopental. As Liptak reports, "properly administered... ... - CounterPunch,

No death penalty for Moussaoui  May 4, 2006
Not that there are many people more deserving of a federally-sanctioned ride on the old “injected with sodium thiopental, paralytic catalyst pancuronium ... - UI Argonaut Online,

Merciful (but messy) alternatives to lethal injection.  May 5, 2006
...receptors aplenty.) And as tendentious as this may sound, it's not so far from the current fuss over the proper dosage of sodium thiopental for anesthetizing a ... - Slate

Lethal injection challenges mount  May 1, 2006
...execution will cause him "to consciously suffer an excruciatingly painful and protracted death." His lawsuit alleges that if the sodium thiopental wears off ... - Denton Record Chronicle (subscription),

Concerns About Pain Put Lethal Injection on Trial  Apr 24, 2006
The first drug administered, the sedative sodium thiopental, is meant to deaden pain, the second, a paralytic, to immobilize the prisoner and the third ... - ktla 5,

Justices to consider if lethal-injection appeal can be heard  Apr 25, 2006
Human Rights Watch contends that states do not have the safeguards to ensure that a prisoner is unconscious from the anesthetic (sodium thiopental) before the ... - USA Today

Lethal injections - will they ever be too barbaric?  Apr 24, 2006
The first, sodium thiopental, intended to anaesthetise the condemned, is claimed by defence counsel to merely cast a “chemical veil� over the pain. ... - Times Online,

Supreme Court to hear challenge to method of lethal injection  Apr 25, 2006
The group, which has filed a "friend of the court" brief on behalf of Hill, argues that the first drug, sodium thiopental, a short-acting barbiturate, is ... - San Jose Mercury News,

Lethal injection may cause agony: rights group  Apr 23, 2006
In the standard method used by 38 states, the condemned are injected with three successive drugs: the anesthetic sodium thiopental which renders the inmate ... - Daily Times,

US: States Negligent in Use of Lethal Injections  Apr 23, 2006
A massive dose of sodium thiopental, an anesthetic, is injected first, followed by pancuronium bromide, which paralyzes voluntary muscles, but leaves the ... - Reuters AlertNet,

Lethal Injection Far From Painless, Study Suggests  Apr 23, 2006
The first drug, the sedative sodium thiopental, is meant to deaden pain, the second, a paralytic, to freeze prisoners and the third, potassium chloride, to ... - Los Angeles Times,

Mack execution more open than previous deaths  Apr 26, 2006
Under the heading: "Drugs of Choice," the protocol says "the lethal substances and amounts to be used in the execution are: Sodium Thiopental 5 grams. ... - Reno Gazette Journal,

Nevada prison officials move ahead with execution plans  Apr 25, 2006
...flow. Mack will first get an overdose of sodium thiopental, a "downer" that will make him unconscious and can cause death. Another ... - Las Vegas Sun,

Impact of ECT on Health-Related Quality of Life and Function in ...  Apr 29, 2006
Dew RE, Kimball JN, Rosenquist PB, McCall WV (2005), Seizure length and clinical outcome in electroconvulsive therapy using methohexital or thiopental. ... - Psychiatric Times,

Lethal doses under fire  Apr 23, 2006
The first drug, the sedative sodium thiopental, is meant to deaden pain; the second, a paralytic, to freeze a prisoner and the third, potassium chloride, to ... - News & Observer,

Dosage Forms POWDER FOR SOLUTION
Drug_Category Anesthetics; Hypnotics and Sedatives; Anticonvulsants; General Anesthetics; ATC:N01AF03; ATC:N05CA19
Absorption Not Available
Interactions Interactions for Thiopental:

The following drug interactions have been reported with thiopental.

Drug Effect
   Probenecid    Prolonged action of thiopental 
   Diazoxide    Hypotension
   Zimelidine    Thiopental antagonism 
   Opioid analgesics    Decreased antinociceptive action
   Aminophylline     Thiopental antagonism
   Midazolam    Synergism

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name 5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione
Chemical Formula C11H18N2O2S
Molecular Weight 242.339 g/mol
Smiles String CCCC(C)C1(C(=O)NC(=NC1=O)S)CC
Melting Point Not Available
Water Solubility Not Available
State Solid
LogP/Hphobicity 3.05
Isoelectric Point Not Available
Biotransformation Not Available
Half Life 3-8 hours
Protein Binding [%] Not Available
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Thiopental.html
http://www.rxlist.com/cgi/generic3/thiopental.htm
Drug Type Approved Drug
Accession No APRD00660
CAS Registry Number 76-75-5
KEGG Compound ID C07521
PubChem ID SID:9724
PharmGKB ID PA451664
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 38393

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