|
![]() |
|
|
Thiopental
drug data and news
Thiopental drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
|
| Generic name | Thiopental | ||||||||||||||
| Brand Names/Synonyms | Dea No. 2100; Farmotal; Intraval; Nesdonal; Penthiobarbital; Pentothal; Pentothiobarbital; Robinax; Thiomebumal; Thionembutal; Thiopental; Thiopentobarbital; Thiopentobarbitone; Thiopentobarbituric Acid; Thiopentone; Thiothal; Tiopentale; Tiopentale [Italian]; Trapanal | ||||||||||||||
| Indication | Intravenous anaesthetic | ||||||||||||||
| Sponsored links | Description | Not Available | |||||||||||||
| Pharmacology | Thiopental, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation. | ||||||||||||||
| Mechanism Of Action | Thiopental binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. | ||||||||||||||
| Thiopental News (When available) |
Fog over executions could clear today 16 May 2006 Lethal injection challenge May 8, 2006 “Botched executions� findings expose grisly practice US: Legal ... May 9, 2006 How Does It Feel? May 3, 2006 Challenges slow US executions Apr 23, 2006 Cruel punishment of lethal injection Apr 18, 2006 Lethal injection a cruel death? May 7, 2006 Doctors and Lethal Injection Apr 20, 2006 No death penalty for Moussaoui May 4, 2006 Merciful (but messy) alternatives to lethal injection. May 5, 2006 Lethal injection challenges mount May 1, 2006 Concerns About Pain Put Lethal Injection on Trial Apr 24, 2006 Justices to consider if lethal-injection appeal can be heard Apr 25, 2006 Lethal injections - will they ever be too barbaric? Apr 24, 2006 Supreme Court to hear challenge to method of lethal injection Apr 25, 2006 Lethal injection may cause agony: rights group Apr 23, 2006 US: States Negligent in Use of Lethal Injections Apr 23, 2006 Lethal Injection Far From Painless, Study Suggests Apr 23, 2006 Mack execution more open than previous deaths Apr 26, 2006 Nevada prison officials move ahead with execution plans Apr 25, 2006 Impact of ECT on Health-Related Quality of Life and Function in ... Apr 29, 2006 Lethal doses under fire Apr 23, 2006 | ||||||||||||||
| Dosage Forms | POWDER FOR SOLUTION | ||||||||||||||
| Drug_Category | Anesthetics; Hypnotics and Sedatives; Anticonvulsants; General Anesthetics; ATC:N01AF03; ATC:N05CA19 | ||||||||||||||
| Absorption | Not Available | ||||||||||||||
| Interactions |
Interactions for Thiopental: The following drug interactions have been reported with thiopental.
| ||||||||||||||
| Toxicity | Not Available | ||||||||||||||
| Organisms Affected | Humans and other mammals | ||||||||||||||
| Chemical IUPAC Name | 5-ethyl-5-(1-methylbutyl)-2-sulfanyl-1H-pyrimidine-4,6-dione | ||||||||||||||
| Chemical Formula | C11H18N2O2S | ||||||||||||||
| Molecular Weight | 242.339 g/mol | ||||||||||||||
| Smiles String | CCCC(C)C1(C(=O)NC(=NC1=O)S)CC | ||||||||||||||
| Melting Point | Not Available | ||||||||||||||
| Water Solubility | Not Available | ||||||||||||||
| State | Solid | ||||||||||||||
| LogP/Hphobicity | 3.05 | ||||||||||||||
| Isoelectric Point | Not Available | ||||||||||||||
| Biotransformation | Not Available | ||||||||||||||
| Half Life | 3-8 hours | ||||||||||||||
| Protein Binding [%] | Not Available | ||||||||||||||
| RxList Link | RXlist | ||||||||||||||
| Sponsored links | |||||||||||||||
| Drug Reference |
http://www.drugs.com/cons/Thiopental.html http://www.rxlist.com/cgi/generic3/thiopental.htm | ||||||||||||||
| Drug Type | Approved Drug | ||||||||||||||
| Accession No | APRD00660 | ||||||||||||||
| CAS Registry Number | 76-75-5 | ||||||||||||||
| KEGG Compound ID | C07521 | ||||||||||||||
| PubChem ID | SID:9724 | ||||||||||||||
| PharmGKB ID | PA451664 | ||||||||||||||
| SwissProt ID | Not Available | ||||||||||||||
| GenBank ID | Not Available | ||||||||||||||
| Drug ID Number [DIN] | 38393 |
|
Home | About | Cancers | Treatment | Medications Copyright onconews.org 2005. All Rights Reserved. |