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Thiamylal
drug data and news
Thiamylal drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Thiamylal
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| Brand Names/Synonyms |
Dea No. 2100; Surital; Thiamylal; Thiamylal [Usan]; Thioseconal |
| Indication |
Used for the production of complete anaesthesia of short duration; For the induction of general anaesthesia;For inducing a hypnotic state |
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Description |
Not Available |
| Pharmacology |
Thiamylal, a barbiturate, is used in combination with acetaminophen or aspirin and caffeine for its sedative and relaxant effects in the treatment of tension headaches, migraines, and pain. Barbiturates act as nonselective depressants of the central nervous system (CNS), capable of producing all levels of CNS mood alteration from excitation to mild sedation, hypnosis, and deep coma. In sufficiently high therapeutic doses, barbiturates induce anesthesia. |
| Mechanism Of Action |
Thiamylal binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. |
Thiamylal News
(When available) |
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| Dosage Forms |
POWDER FOR SOLUTION |
| Drug_Category |
Anesthetics; Hypnotics and Sedatives; ATC:M01A |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
5-(1-methylbutyl)-5-prop-2-enyl-2-sulfanyl-1H-pyrimidine-4,6-dione |
| Chemical Formula |
C12H18N2O2S |
| Molecular Weight |
254.35 g/mol |
| Smiles String |
CCCC(C)C1(C(=O)NC(=NC1=O)S)CC=C |
| Melting Point |
132-133 °C |
| Water Solubility |
49.4 mg/L |
| State |
Solid |
| LogP/Hphobicity |
2.848 |
| Isoelectric Point |
7.48 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00154 |
| CAS Registry Number |
77-27-0 |
| KEGG Compound ID |
C07846 |
| PubChem ID |
SID:10048 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
620823
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