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Tetracycline
drug data and news
Tetracycline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Tetracycline | ||
| Brand Names/Synonyms | Abramycin; Abricycline; Achromycin; Achromycin V; Achromycin, Naphthacene Derivative; Actisite; Agromicina; Ambramicina; Ambramycin; Amycin; Anhydrotetracycline; Aureomycin; Bio-Tetra; Biocycline; Bristaciclin α; Bristaciclina; Bristacycline; Cefracycline; Cefracycline Suspension; Ciclibion; Copharlan; Criseociclina; Cyclomycin; Cyclopar; Cytome; Democracin; Deschlorobiomycin; Dumocyclin; Enterocycline; HSDB 3188; Hostacyclin; Lexacycline; Limecycline; Liquamycin; Liquamycin, Veterinary; Medocycline; Mericycline; Micycline; Neocycline; Oletetrin; Omegamycin; Orlycycline; Oxytetracycline Hcl; Panmycin; Polycycline; Polyotic; Purocyclina; Resteclin; Retet; Robitet; Roviciclina; Sk-Tetracycline; Solvocin; Sumycin; Sumycin Syrup; T-125; TAC; TC; Terramycin; Tetra-Co; Tetrabon; Tetrachel; Tetracycl; Tetracycline; Tetracycline Base; Tetracycline Free Base; Tetracycline Hcl; Tetracycline Ii; Tetracyclinetetracycline I; Tetracyn; Tetradecin; Tetrafil; Tetramed; Tetraverine; Tetrex; Topicycline; Tsiklomistsin; Tsiklomitsin; Veracin; Vetacyclinum | ||
| Indication | For the treatment of infections caused by Mycoplasma pneumoniae, chlamydiae, and rickettsiae, syphilis gonorrhea; For the treatment of respiratory infections, bacterial enteritis, meningcoccal carrier state, Lyme disease, cholera, brucellosis, leptospirosis, plague, and acne. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Semisynthetically produced from chlortetracycline, which is derived from Streptomyces aureofaciens, tetracycline is classified as a short-acting tetracycline. Tetracycline is used to treat infections due to rickettsia, Mycoplasma pneumonia, and chlamydia, Lyme disease, brucellosis, and syphilis by inhibiting protein synthesis in the susceptible organisms. | ||
| Mechanism Of Action | Tetracyclines passively diffuse through porin channels in the bacterial membrane, reversibly binding to the 30 S ribosomal subunit, preventing binding of tRNA to the mRNA-ribosome complex, and thus interfering with protein synthesis. | ||
| Tetracycline News (When available) |
US: price suspicions prompt organic food concerns 16 May 2006 Zinc Supplement May 14, 2006 Natural Products Reemerge May 10, 2006 New Broad-spectrum Antibiotic Tygacil (tigecycline) Receives ... May 3, 2006 Dangers in the Medicine Cabinet May 12, 2006 Barr Receives Approval for Isotretinoin Capsules USP, 30 mg May 12, 2006 Efforts afoot to return the species to the Susquehanna Apr 23, 2006 Sunglasses: A Must Accessory May 6, 2006 Ancestors get due May 6, 2006 NC doctor faces board discipline over treatment Apr 17, 2006 Induction ceremonies are tribute to brainiacs May 7, 2006 Pig farming: a lucrative business for small and medium scale ... Apr 17, 2006 NC doctor's license on the line over Lyme treatment Apr 22, 2006 Medicis Announces FDA Approval of SOLODYN -- minocycline HCl, USP ... May 8, 2006 Novel antibiotic from Wyeth gets green light in Europe May 3, 2006 Uganda: Misplaced Hope At Home Apr 20, 2006 The skin-friendly tan Apr 25, 2006 More Papuans die in diarrhea outbreak Apr 25, 2006 Calcium is critical — especially for kids Apr 30, 2006 Prescriptions can assist acne cases where OTC options fail Apr 23, 2006 Julius Berger Imports Fake Drugs, Says NAFDAC Apr 20, 2006 Dog owners warn about fish poisoning Apr 18, 2006 Unlicensed drug peddler pleads guilty, fined Apr 17, 2006 'Treatment of Discolored Teeth' Apr 30, 2006 Everything about Acne and Treatments for Acne that are Guaranteed ... Apr 17, 2006 The truth about teeth whitening Apr 27, 2006 Study: Cut antibiotic use in food animals Apr 17, 2006 Australia's antibiotic ban reduces incidence of drug resistance ... Apr 18, 2006 | ||
| Dosage Forms | Tablet; Oral Suspension; Capsule; Topical Solution; Ophthalmic Suspension; IV Injection; IM Injection; Ointment | ||
| Drug_Category | Anti-bacterial Agents; Antiprotozoal; Tetracyclines; ATC:A01AB13; ATC:A01AB21; ATC:D06AA02; ATC:D06AA03; ATC:D06AA04; ATC:G01AA07; ATC:J01AA03; ATC:J01AA06; ATC:J01AA07; ATC:J01AA09; ATC:S01AA02; ATC:S01AA04; ATC:S01AA09; ATC:S02AA08; ATC:S03AA02 | ||
| Absorption | 60-80% in fasting adults; Food and/or milk reduce GI absorption of oral preparations of tetracycline by 50% or more. | ||
| Interactions | [an error occurred while processing this directive]Toxicity | LD50=808mg/kg (orally in mice) | |
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 2-(amino-hydroxy-methylidene)-4-dimethylamino-6,10,11,12a-tetrahydroxy-6-methyl-4,4a,5,5a-tetrahydrotetracene-1,3,12-trione | ||
| Chemical Formula | C22H24N2O8 | ||
| Molecular Weight | 444.435 g/mol | ||
| Smiles String | CC1(C2CC3C(C(=O)C(=C(N)O)C(=O)C3(C(=O)C2=C(C4=C1C=CC=C4O)O)O)N(C)C)O | ||
| Melting Point | 165°C | ||
| Water Solubility | 1.7mg/ml | ||
| State | Solid | ||
| LogP/Hphobicity | -0.304 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 6-11 hours | ||
| Protein Binding [%] | bound to plasma proteins in varying degree | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Tetracycline.html http://www.rxlist.com/cgi/generic2/tetcycl2.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00572 | ||
| CAS Registry Number | 60-54-8 | ||
| KEGG Compound ID | C06570 | ||
| PubChem ID | SID:407983 | ||
| PharmGKB ID | PA451640 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 527777 |
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