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Testosterone
drug data and news
Testosterone drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Testosterone | ||
| Brand Names/Synonyms | AA 2500; Andriol; Andro; Andro 100; Andro L.A. 200; Androderm; Androgel; Android 10; Android 25; Android 5; Androlin; Andronaq; Andronate 100; Andronate 200; Andropatch; Andropository 200; Andrusol; Andryl 200; Beta Testosterone; CCRIS 574; CDB 111C; COL 1621; CP 601B; Cristerona T; Cristerone T; Dea No. 4000; Delatest; Delatestryl; Depo-Testosterone; Depo-Testosterone Cypionate; Depotest; Dofsol; Everone 200; Geno-Cristaux Gremy; HSDB 3398; Homosteron; Homosterone; Libigel; Malerone; Malestrone; Malogen in Oil; Malogen, Aquaspension Injection; Mertestate; Metandren; Methyltestosterone; NSC 9700; Neo-Hombreol F; Neo-Testis; Neotestis; Oreton; Oreton F; Oreton Methyl; Oreton-F; Orquisteron; Perandren; Percutacrine Androgenique; Primotest; Primoteston; Relibra; Scheinpharm Testone-Cyp; Striant; Sustanon; Sustanone; Sustason 250; Synandrol F; T-Cypionate; TES; Teslen; Testamone 100; Testandrone; Testaqua; Testex; Testiculosterone; Testim; Testobase; Testoderm; Testoderm Tts; Testogel; Testoject-50; Testolin; Testopel Pellets; Testopropon; Testosteroid; Testosteron; Testosterona [Inn-Spanish]; Testosterone; Testosterone Cypionate; Testosterone Enanthate; Testosterone Hydrate; Testosterone Propionate; Testosterone [Ban:Inn]; Testosterone and Its Esters; Testosteronum [Inn-Latin]; Testostosterone; Testoviron; Testoviron Schering; Testoviron T; Testred; Testred Cypionate 200; Testrin-P.A; Testro Aq; Testrone; Testryl; Trans-Testosterone; Virilon; Virilon Im; Virormone; Virosterone | ||
| Indication | For topical testosterone replacement therapy in males with deficiency or absence of testosterone | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Testosterone is an antineoplastic hormonal agent primarily used in the treatment of prostate cancer. Testosterone is a pure, nonsteroidal anti-androgen with affinity for androgen receptors (but not for progestogen, estrogen, or glucocorticoid receptors). Consequently, Testosterone blocks the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue. Prostate cancer is mostly androgen-dependent and can be treated with surgical or chemical castration. To date, antiandrogen monotherapy has not consistently been shown to be equivalent to castration. | ||
| Mechanism Of Action | Testosterone competes with androgen for the binding of androgen receptors, consequently blocking the action of androgens of adrenal and testicular origin which stimulate the growth of normal and malignant prostatic tissue. | ||
| Testosterone News (When available) |
Doctor's wife accused of murder for hire 16 May 2006 Hormones, not environment, make women different from men 16 May 2006 VIVUS to Host Analyst Day Webcast on Thursday, May 18th 16 May 2006 World Cup fever leaves me a baffled alien 16 May 2006 Can Alvarez still be a strong mayor? 16 May 2006 Straight truth: Addressing the gay issue 16 May 2006 The Iran Hostage Crisis: Déjà Vu in the Middle East 16 May 2006 The Research - The Hard Times (At Large) 16 May 2006 Pop goes the opera 16 May 2006 Network that hates surprises may have one 16 May 2006 Riddle me this 16 May 2006 Viewers who read more: 0 16 May 2006 Seeing the need 16 May 2006 Confusion Over Hormone Replacement Therapy 16 May 2006 The Sex O'Clock news 16 May 2006 Takara Bio to research yam use in functional foods 16 May 2006 THE NEW MAN: Fresh ads forgo bikini models -- and they're funny 16 May 2006 The latest potshot at guns is getting me all riled up May 15, 2006 Women tell if men like children by reading what's written on face May 15, 2006 Guns can set a man's testosterone flowing May 9, 2006 Women Low on Testosterone Get Boost from Patch May 10, 2006 Do Testosterone Patches Help Women with Under-active Pituitary ... May 10, 2006 Testosterone patches help women with under-active pituitary glands May 11, 2006 Testosterone patches work with some women May 10, 2006 DVD Review: Testosterone May 12, 2006 Meitus: Testosterone takes control when high-def comes home May 12, 2006 Add a pinch of testosterone May 3, 2006 Testosterone patches could help women with hypopituitarism May 10, 2006 Testosterone makes you indecisive Apr 19, 2006 The victory of testosterone Apr 22, 2006 THE MAN SHOW Testosterone triumphs over creativity in CBS' macho ... Apr 25, 2006 Testosterone Levels Rebound after Androgen Deprivation Apr 19, 2006 Testosterone Makes Men Vulnerable Apr 20, 2006 Testosterone teems at EV expo Apr 23, 2006 Vital Signs Risk: For Men, Low Estrogen Level Puts Hips in Peril May 15, 2006 Lower Testosterone Levels Among Some Diabetic Patients May Lead to ... Apr 27, 2006 She took the testosterone road to manhood Apr 24, 2006 High-testosterone men’s judgment impaired by seeing sexy photos Apr 29, 2006 Women Attracted To Men When They See Interest In Children Refected ... May 14, 2006 Testosterone patches could help women with under-active pituitary ... May 10, 2006 HIGH SCHOOL GRADUATION: Classy in camo May 15, 2006 Women Attracted To Men When They See Interest In Children Refected ... May 10, 2006 She took testosterone road to manhood May 4, 2006 Women’s Intuition and Blurred Vision May 15, 2006 Eyes on the Thighs May 16, 2006 | ||
| Dosage Forms | CAPSULE; GEL; LIQUID; PATCH; SOLUTION; SUSPENSION | ||
| Drug_Category | Antineoplastic Agents; Anabolic Agents; Androgens; ATC:G03BA02; ATC:G03BA03; ATC:G03EK01 | ||
| Absorption | Approximately 10% of the testosterone dose applied on the skin surface from AndroGel® is absorbed into systemic circulation | ||
| Interactions |
-->Interactions for Testosterone: Oxyphenbutazone: Concurrent administration of oxyphenbutazone and androgens may result in elevated serum levels of oxyphenbutazone. Insulin: In diabetic patients, the metabolic effects of androgens may decrease blood glucose and, therefore, insulin requirements. Propranolol: In a published pharmacokinetic study of an injectable testosterone product, administration of testosterone cypionate led to an increased clearance of propranolol in the majority of men tested. Corticosteroids: The concurrent administration of testosterone with ACTH or corticosteroids may enhance edema formation; thus, these drugs should be administered cautiously, particularly in patients with cardiac or hepatic disease. Drug/Laboratory Test Interactions Androgens may decrease levels of thyroxin-binding globulin, resulting in decreased total T4 serum levels and increased resin uptake of T3 and T4. Free thyroid hormone levels remain unchanged, however, and there is no clinical evidence of thyroid dysfunction. | ||
| Toxicity | Side effects include amnesia, anxiety, discolored hair, dizziness, dry skin, hirsutism, hostility, impaired urination, paresthesia, penis disorder, peripheral edema, sweating, and vasodilation. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 17-hydroxy-10,13-dimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydrocyclopenta[a]phenanthren-3-one | ||
| Chemical Formula | C19H28O2 | ||
| Molecular Weight | 288.424 g/mol | ||
| Smiles String | CC12CCC3C(C1CCC2O)CCC4=CC(=O)CCC34C | ||
| Melting Point | 155 °C | ||
| Water Solubility | 23.4 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 3.518 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Testosterone is metabolized to 17-keto steroids. | ||
| Half Life | 10-100 minutes | ||
| Protein Binding [%] | 40% of testosterone in plasma is bound to sex hormone-binding globulin and 2% remains unbound and the rest is bound to albumin and other proteins. | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/tes1438.shtml http://www.drugs.com/cons/Testosterone.html http://www.rxlist.com/cgi/generic2/androgel.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00433 | ||
| CAS Registry Number | 58-22-0 | ||
| KEGG Compound ID | C00535 | ||
| PubChem ID | SID:320523 | ||
| PharmGKB ID | PA451627 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2246063 |
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