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Terconazole
drug data and news
Terconazole drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Terconazole | ||
| Brand Names/Synonyms | Fungistat; Gyno-Terazol; Terazol; Terazol 3; Terazol 7; Terconazole; Tercospor; Triaconazole | ||
| Indication | Candidiasis (a yeast-like fungal infection) of the vulva and vagina | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Terconazole is a triazole antifungal agent available for intravaginal use. It is structurally related to imidazole-derivative antifungal agents, although terconazole and other triazoles have 3 nitrogens in the azole ring. | ||
| Mechanism Of Action | Terconazole may exert its antifungal activity by disrupting normal fungal cell membrane permeability. Terconazole and other triazole antifungal agents inhibit cytochrome P450 14-alpha-demethylase in susceptible fungi, which leads to the accumulation of lanosterol and other methylated sterols and a decrease in ergosterol concentration. | ||
| Terconazole News (When available) |
Perrigo Company Reports Third Quarter Fiscal 2006 Financial ... Apr 27, 2006 | ||
| Dosage Forms | Vaginal cream and Vaginal suppositories | ||
| Drug_Category | Antifungals; Antifungals; ATC:G01AG02 | ||
| Absorption | Following intravaginal administration of terconazole in humans, absorption ranged from 5-8% in three hysterectomized subjects and 12-16% in two non-hysterectomized subjects with tubal ligations | ||
| Interactions |
-->Interactions for Terconazole: TERAZOL 7 Vaginal Cream 0.4% and TERAZOL 3 Vaginal Suppositories 80 mg The therapeutic effect of these products is not affected by oral contraceptive usage. TERAZOL 3 Vaginal Cream 0.8% The levels of estradiol (E2) and progesterone did not differ significantly when 0.8% terconazole vaginal cream was administered to healthy female volunteers established on a low dose oral contraceptive. | ||
| Toxicity | the oral LD 50 values were found to be 1741 and 849 mg/kg for the male and female in Rat. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 1-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-4-(1-methylethyl)piperazine | ||
| Chemical Formula | C26H31Cl2N5O3 | ||
| Molecular Weight | 532.462 g/mol | ||
| Smiles String | CC(C)N1CCN(CC1)C2=CC=C(C=C2)OCC3COC(O3)(CN4C=NC=N4)C5=C(C=C(C=C5)Cl)Cl | ||
| Melting Point | 126.3°C | ||
| Water Solubility | Not Available | ||
| State | white to almost white powder | ||
| LogP/Hphobicity | 5.361 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 6.9 hours (range 4.0-11.3) | ||
| Protein Binding [%] | 94.90% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Terconazole.html http://www.rxlist.com/cgi/generic/tercon.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00659 | ||
| CAS Registry Number | 67915-31-5 | ||
| KEGG Compound ID | C08080 | ||
| PubChem ID | SID:66595 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2247651 |
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