Terbinafine drug data and news

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Fungal prosthetic mitral valve endocarditis caused by ...  May 9, 2006
Calif) identified the organism as S brevicaulis and demonstrated mean inhibitory concentrations of 4 µg/mL to amphotericin B, 1 µg/mL to terbinafine, 8 µg ... - The Journal of Thoracic and Cardiovascular Surgery

(PZ) Novartis Delivers Strong Start to 2006 in First Quarter with ...  Apr 24, 2006
...since the 2005 first quarter included the antibiotics azithromycin (Zithromax(R)) and ceftriaxone (Rocephin(R)) in the US as well as terbinafine (Lamisil) and ... - Houston Chronicle,

Sore Feet a Sure Sign of Aging  Apr 21, 2006
Oral medications for fungal infections, including fungal nails and athlete's foot, are Lamisil (terbinafine) made by Novartis Pharmaceuticals of East Hanover ... - SeniorJournal.com,

Novartis Delivers Strong Start to 2006 in First Quarter with ...  Apr 24, 2006
...since the 2005 first quarter included the antibiotics azithromycin (Zithromax®) and ceftriaxone (Rocephin®) in the US as well as terbinafine (Lamisil) and a ... - PharmaLive.com (press release),

In vitro studies with human liver microsomes showed that terbinafine does not inhibit the metabolism of tolbutamide, ethinylestradiol, ethoxycoumarin, and cyclosporine. In vitro studies have also shown that terbinafine inhibits CYP2D6-mediated metabolism. This may be of clinical relevance for compounds predominantly metabolized by this enzyme, such as tricyclic antidepressants, ß-blockers, selective serotonin reuptake inhibitors (SSRIs), and monoamine oxidase inhibitors (MAO-Is) Type B, if they have a narrow therapeutic window.

In vivo drug-drug interaction studies conducted in normal volunteer subjects showed that terbinafine does not affect the clearance of antipyrine or digoxin. Terbinafine decreases the clearance of caffeine by 19%. Terbinafine increases the clearance of cyclosporine by 15%.

There have been spontaneous reports of increase or decrease in prothrombin times in patients concomitantly taking oral terbinafine and warfarin, however, a causal relationship between LAMISIL^® Tablets and these changes has not been established.

Terbinafine clearance is increased 100% by rifampin, a CyP450 enzyme inducer, and decreased 33% by cimetidine, a CyP450 enzyme inhibitor. Terbinafine clearance is unaffected by cyclosporine.

There is no information available from adequate drug-drug interaction studies with the following classes of drugs: oral contraceptives, hormone replacement therapies, hypoglycemics, theophyllines, phenytoins, thiazide diuretics, beta blockers, and calcium channel blockers.