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Tamsulosin
drug data and news
Tamsulosin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Tamsulosin | ||
| Brand Names/Synonyms | Flomax; Harnal; Omnic; Pradif; TAMSULOSIN; Tamsolusin; Tamsulosin; Tamsulosina [Inn-Spanish]; Tamsulosine [Inn-French]; Tamsulosinum [Inn-Latin] | ||
| Indication | Used in the treatment of signs and symptoms of benign prostatic hyperplasia. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Tamsulosin, an alpha-adrenoceptor blocker with enhanced specificity for the alpha-adrenoceptors of the prostate, is commonly used to treat benign prostatic hyperplasia (BPH). | ||
| Mechanism Of Action | Tamsulosin is a selective antagonist at alpha-1A and alpha-1B-adrenoceptors in the prostate, prostatic capsule, prostatic urethra, and bladder neck. At least three discrete alpha1-adrenoceptor subtypes have been identified: alpha-1A, alpha-1B and alpha-1D; their distribution differs between human organs and tissue. Approximately 70% of the alpha1-receptors in human prostate are of the alpha-1A subtype. Blockage of these receptors causes relaxation of smooth muscles in the bladder neck and prostate. | ||
| Tamsulosin News (When available) |
Wockhardt Q1 net loss at Rs 3.7 cr Apr 25, 2006 Threshold BPH Drug Hits Bump; Stock Tumbles On Liver Toxicity May 12, 2006 SkyePharma PLC - Preliminary Results Announcement for the Year ... Apr 19, 2006 | ||
| Dosage Forms | CAPSULE (SUSTAINED-RELEASE) | ||
| Drug_Category | Antineoplastic Agents; ATC:G04CA02 | ||
| Absorption | Absorption of tamsulosin HCI from capsules 0.4 mg is essentially complete (>90%) following oral administration under fasting conditions. | ||
| Interactions |
Interactions for Tamsulosin: Drug-Drug Interactions: The pharmacokinetic and pharmacodynamic interactions between FLOMAX capsules and other alpha-adrenergic blocking agents have not been determined. However, interactions may be expected and FLOMAX capsules should NOT be used in combination with other alpha-adrenergic blocking agents. The pharmacokinetic interaction between cimetidine and FLOMAX capsules was investigated. The results indicate significant changes in tamsulosin HCI clearance (26% decrease) and AUC (44% increase). Therefore, FLOMAX capsules should be used with caution in combination with cimetidine, particularly at doses higher than 0.4 mg. Results from limited in vitro and in vivo drug-drug interaction studies between tamsulosin HCI and warfarin are inconclusive. Therefore, caution should be exercised with concomitant administration of warfarin and FLOMAX capsules.
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| Toxicity | LD50 = 650 mg/kg (in rats) | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 5-[2-[2-(2-ethoxyphenoxy)ethylamino]propyl]-2-methoxy-benzenesulfonamide | ||
| Chemical Formula | C20H28N2O5S | ||
| Molecular Weight | 408.513 g/mol | ||
| Smiles String | CCOC1=CC=CC=C1OCCNC(C)CC2=CC(=C(C=C2)OC)S(=O)(=O)N | ||
| Melting Point | 226-228 oC (HCl salt) | ||
| Water Solubility | Sparingly soluble in water | ||
| State | Solid | ||
| LogP/Hphobicity | 3.363 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Tamsulosin HCI is extensively metabolized by cytochrome P450 enzymes in the liver, however, the pharmacokinetic profile of the metabolites in humans has not been established. | ||
| Half Life | 5-7 hours | ||
| Protein Binding [%] | 94%-99% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Tamsulosin.html http://www.rxlist.com/cgi/generic2/tamsul.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00036 | ||
| CAS Registry Number | 106133-20-4 | ||
| KEGG Compound ID | C07124 | ||
| PubChem ID | SID:668003 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2238123 |
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