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Suprofen
drug data and news
Suprofen drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Suprofen
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| Brand Names/Synonyms |
Indocid; Maldocil; Masterfen; Ocufen; Profenal; Srendam; Sulproltin; Supranol; Suprofen; Suprofenum [Inn-Latin]; Suprol; Sutoprofen; Topalgic; Voltaren Ophthalmic; [Inn-French] |
| Indication |
Used as eye drops to inhibit the miosis (pupil constriction) that may occur during ocular surgery |
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Description |
Not Available |
| Pharmacology |
Suprofen is a non-steroidal anti-inflammatory drug that is used to treat ophthalmic inflammatory disease. Ophthalmic anti-inflammatory medicines are used in the eye to lessen problems that can occur during or after some kinds of eye surgery. Sometimes, the pupil of the eye gets smaller during an operation (pupil constriction). This makes it more difficult for the surgeon to reach some areas of the eye. Suprofen is used to help prevent this. |
| Mechanism Of Action |
Binds to the COX-1 and COX-2 enzymes, preventing the synthesis of prostaglandins and reducing the inflammatory response. This reduces pain and inflammation in the eyes and prevents pupil constriction during surgery. Normally trauma to the anterior segment of the eye (esp. the iris) increases endogenous prostaglandin synthesis which leads to constriction of the iris sphincter. |
Suprofen News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Anti-inflammatory Agents; ATC:M01AE07 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
2-(4-thiophen-2-ylcarbonylphenyl)propanoicacid |
| Chemical Formula |
C14H12O3S |
| Molecular Weight |
260.309 g/mol |
| Smiles String |
CC(C1=CC=C(C=C1)C(=O)C2=CC=CS2)C(=O)O |
| Melting Point |
124.3 °C |
| Water Solubility |
limited solubility |
| State |
Solid |
| LogP/Hphobicity |
2.919 |
| Isoelectric Point |
3.91 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
20% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Suprofen.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00230 |
| CAS Registry Number |
40828-46-4 |
| KEGG Compound ID |
C07320 |
| PubChem ID |
SID:179853 |
| PharmGKB ID |
PA451569 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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