Sumatriptan drug data and news

Sumatriptan drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Sumatriptan
Brand Names/Synonyms CHEMBANK1724; Imigran; Imitrex; Sumatran; Sumatriptan; Sumatriptan Succinate; Sumatriptanum [Inn-Latin]; Sumax
Indication For the treatment of migraine attacks with or without aura in adults
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Description Not Available
Pharmacology Sumatriptan, an antimigraine drug, is structurally similar to serotonin. It is thought that the cerebral blood vessel constriction induced by activation of 5-HT1 receptors on those vessels may contribute to the antimigrainous effect of sumatriptan in humans.
Mechanism Of Action Sumatriptan stimulates 5-HT receptors of the 1D subtype, most likely presynaptic receptors, resulting in selective vasoconstriction of inflamed and dilated cranial blood vessels in the carotid circulation. Sumatriptan also blocks the release of vasoactive neuropeptides from perivascular trigeminal axons in the dura mater during migraine and may inhibit the release of inflammatory mediators from the trigeminal nerve.
Sumatriptan News
(When available)

Pain Therapeutics - Drugs, Markets and Companies  16 May 2006
Various pain syndromes require different approaches in management, for example, the main category of drugs for migraine are triptans such as sumatriptan. ... - PharmaLive.com (press release),

Aradigm Reports First Quarter 2006 Financial Results and Corporate ...  May 15, 2006
...period obligations, the pay-down of accounts payable for the fourth quarter of 2005 activities tied to completion of the Intraject Sumatriptan stability lot ... - Market Wire (press release)

Spectrum Pharmaceuticals Reports First Quarter 2006 Financial ...  May 8, 2006
...into a strategic alliance with Par Pharmaceuticals to distribute our generic products, including, once approved by the FDA, sumatriptan succinate injection ... - PR Newswire (press release),

Your health questions answered  May 2, 2006
One, sumatriptan nasal spray, can be used once a child is 12. Until then, I suggest trying ibuprofen at the first sign of headache. ... - Independent,

Experts recommend Aspirin® for the treatment of migraine  Apr 27, 2006
...“Studies have confirmed that ASA is as effective in the treatment of migraine attacks as the prescription drug sumatriptan,� said Professor Hans-Christoph ... - WebWire (press release),

No More Headaches?  Apr 17, 2006
But it spent less than $30 million on the development of Trexima, which is a combination of sumatriptan, the active ingredient in Imitrex, and the anti ... - Forbes

Ask the Clinician: Answers to Readers' Questions  May 8, 2006
Treatment has been from ergotamine to sumatriptan, Botox to PFO closure, aspirin to Methysergide, homoeopathy to acupuncture to osteopathy, feverfew to lavender ... - About - News & Issues,

Dosage Forms Tablets; Injection; Nasal spray
Drug_Category Vasoconstrictor Agents; Selective Serotonin Agonists; ATC:N02CC01
Absorption ~15%
Interactions Interactions for Sumatriptan:

Ergot-containing drugs have been reported to cause prolonged vasospastic reactions. Because there is a theoretical basis that these effects may be additive, use of ergotamine-containing or ergot-type medications (like dihydroergotamine or methysergide) and sumatriptan within 24 hours of each other should be avoided.

MAO-A inhibitors reduce sumatriptan clearance, significantly increasing systemic exposure. Therefore, the use of sumatriptan succinate tablets in patients receiving MAO-A inhibitors is contraindicated .

Selective serotonin reuptake inhibitors (SSRIs) (e.g., fluoxetine, fluvoxamine, paroxetine, sertraline) have been reported, rarely, to cause weakness, hyperreflexia, and incoordination when coadministered with sumatriptan. If concomitant treatment with sumatriptan and an SSRI is clinically warranted, appropriate observation of the patient is advised.

Toxicity convulsions, tremor, paralysis, inactivity, ptosis, erythema of the extremities, abnormal respiration, cyanosis, ataxia, mydriasis, salivation, and lacrimation; LD50=mg/kg (orally in mice)
Organisms Affected Humans and other mammals
Chemical IUPAC Name 1-[3-(2-dimethylaminoethyl)-1H-indol-5-yl]-N-methyl-methanesulfonamide
Chemical Formula C14H21N3O2S
Molecular Weight 295.402 g/mol
Smiles String CNS(=O)(=O)CC1=CC2=C(C=C1)NC=C2CCN(C)C
Melting Point 169-171 °C
Water Solubility 21.4 mg/ml
State white to off-white powder
LogP/Hphobicity 0.965
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 2.5 hours
Protein Binding [%] 14%-21%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Sumatriptan.html
http://www.rxlist.com/cgi/generic/sumitr.htm
Drug Type Approved Drug
Accession No APRD00379
CAS Registry Number 103628-46-2
KEGG Compound ID C07319
PubChem ID SID:271321
PharmGKB ID PA451566
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2239738

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