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Sulpiride
drug data and news
Sulpiride drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Sulpiride
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| Brand Names/Synonyms |
Abilit; Aiglonyl; Alimoral; CCRIS 4248; CHEMBANK920; Calmoflorine; Championyl; Coolspan; Darleton; Desmenat; Dobren; Dogmatil; Dogmatyl; Dolmatil; Dresent; Eclorion; Eglonil; Eglonyl; Enimon; Equilid; Eusulpid; Fardalan; Fidelan; Guastil; Isnamide; Kylistro; L-Forms: Levosulpiride; Levobren; Levopraid; Levosulpirida [Inn-Spanish]; Levosulpiride; Levosulpiride [Inn]; Levosulpiridum [Inn-Latin]; Lisopiride; Mariastel; Meresa; Miradol; Mirbanil; Misulvan; Neogama; Norestran; Normum; Nufarol; Omiryl; Omperan; Ozoderpin; Psicocen; Pyrikappl; Pyrkappl; R.D. 1403; RD 1403; Restful; S116; S8010; Sernevin; Splotin; Stamonevrol; Sulpirid; Sulpirida [Inn-Spanish]; Sulpiride; Sulpiride [Usan:Ban:Inn:Jan]; Sulpiridum [Inn-Latin]; Sulpitil; Sulpride; Sulpyrid; Suprium; Sursumid; Synedil; Trilan; Valirem; Zemorcon |
| Indication |
Sulpiride is indicated for the treatment of schizophrenia. |
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Description |
Not Available |
| Pharmacology |
Sulpiride is a substituted benzamide derivative and a selective dopamine D2 antagonist with antipsychotic and antidepressant activity. Other benzamide derivatives include metoclopramide, tiapride, and sultopride. |
| Mechanism Of Action |
In contrast to most other neuroleptics which block both dopamine D1 and D2 receptors, Sulpiride is more selective and acts primarily as a dopamine D2 antagonist. Sulpiride appears to lack effects on norepinephrine, acetylcholine, serotonin, histamine, or gamma-aminobutyric acid (GABA) receptors. |
Sulpiride News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Antidepressants; Antipsychotics; ATC:N05AL01; ATC:N05AL07 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
N-[(1-ethylpyrrolidin-2-yl)methyl]-2-methoxy-5-sulfamoyl-benzamide |
| Chemical Formula |
C15H23N3O4S |
| Molecular Weight |
341.427 g/mol |
| Smiles String |
CCN1CCCC1CNC(=O)C2=C(C=CC(=C2)S(=O)(=O)N)OC |
| Melting Point |
178 °C |
| Water Solubility |
2280 mg/L |
| State |
Solid |
| LogP/Hphobicity |
1.337 |
| Isoelectric Point |
9.12 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
APRD00032 |
| CAS Registry Number |
15676-16-1 |
| KEGG Compound ID |
C12653 |
| PubChem ID |
SID:583043 |
| PharmGKB ID |
Not Available |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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