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Sulfapyridine
drug data and news
Sulfapyridine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Sulfapyridine
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| Brand Names/Synonyms |
A-499; Adiplon; Coccoclase; Dagenan; Eporal; Eubasin; Eubasinum; Haptocil; M + B 693; M and B 693; M&B-693; Piridazol; Plurazol; Pyriamid; Pyridazol; Relbapiridina; Ronin; Septipulmon; Streptosilpyridine; Sulfapyridine; Sulfidin; Sulfidine; Sulphapyridine; Thioseptal; Trianon; 2-Sulfanilamidopyridin; 2-Sulfanilamidopyridine; 2-Sulfanilylaminopyridine; 2-Sulfapyridine; 4-(2-Pyridinylsulfonyl)aniline; 4-[(2-Pyridylamino)sulfonyl]aniline; N(sup 1)-2-Pyridylsulfanilamide; N(sup1)-Pyridylsulfanilamide; N-2-Pyridylsulfanilamide; N1-2-Pyridylsulfanilamide; Sulfanilamide, N(sup 1)-2-pyridyl-; Sulfanilamide, N1-2-pyridyl-; Sulfapyridine (USP) |
| Indication |
For the treatment of dermatitis herpetiformis, benign mucous membrane pemphigoid |
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Description |
Not Available |
| Pharmacology |
Sulfapyridine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. |
| Mechanism Of Action |
Sulfapyridine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. |
Sulfapyridine News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Dermatologic Agents; Anti-Infectives; Sulfonamides; ATC:J01EB04 |
| Absorption |
approximately 60–80% |
| Interactions |
Interations
Sulfapyridine may interact with any of the following:
- Acetaminophen (e.g., Tylenol) (with long-term, high-dose use) or
- Amiodarone (e.g., Cordarone) or
- Anabolic steroids (nandrolone [e.g., Anabolin], oxandrolone [e.g., Anavar], oxymetholone [e.g., Anadrol], stanozolol [e.g., Winstrol]) or
- Androgens (male hormones) or
- Antithyroid agents (medicine for overactive thyroid) or
- Carbamazepine (e.g., Tegretol) or
- Carmustine (e.g., BiCNU) or
- Chloroquine (e.g., Aralen) or
- Dantrolene (e.g., Dantrium) or
- Daunorubicin (e.g., Cerubidine) or
- Disulfiram (e.g., Antabuse) or
- Divalproex (e.g., Depakote) or
- Estrogens (female hormones) or
- Etretinate (e.g., Tegison) or
- Gold salts (medicine for arthritis) or
- Hydroxychloroquine (e.g., Plaquenil) or
- Mercaptopurine (e.g., Purinethol) or
- Naltrexone (e.g., Trexan) (with long-term, high-dose use) or
- Oral contraceptives (birth control pills) containing estrogen or
- Other anti-infectives by mouth or by injection (medicine for infection) or
- Phenothiazines (acetophenazine [e.g., Tindal], chlorpromazine [e.g., Thorazine], fluphenazine [e.g., Prolixin], mesoridazine [e.g., Serentil], perphenazine [e.g., Trilafon], prochlorperazine [e.g., Compazine], promazine [e.g., Sparine], promethazine [e.g., Phenergan], thioridazine [e.g., Mellaril], trifluoperazine [e.g., Stelazine], triflupromazine [e.g., Vesprin], trimeprazine [e.g., Temaril]) or
- Plicamycin (e.g., Mithracin) or
- Valproic acid (e.g., Depakene)—Use of sulfapyridine with these medicines may increase the chance of side effects affecting the liver
- Acetohydroxamic acid (e.g., Lithostat) or
- Dapsone or
- Furazolidone (e.g., Furoxone) or
- Nitrofurantoin (e.g., Furadantin) or
- Primaquine or
- Procainamide (e.g., Pronestyl) or
- Quinidine (e.g., Quinidex) or
- Quinine (e.g., Quinamm) or
- Sulfoxone (e.g., Diasone) or
- Vitamin K (e.g., AquaMEPHYTON, Synkayvite)—Use of sulfapyridine with these medicines may increase the chance of side effects affecting the blood
- Anticoagulants (blood thinners) or
- Ethotoin (e.g., Peganone) or
- Mephenytoin (e.g., Mesantoin)—Use of sulfapyridine with these medicines may increase the chance of side effects of these medicines
- Antidiabetics, oral (diabetes medicine you take by mouth)—Use of oral antidiabetics with sulfapyridine may increase the chance of side effects affecting the blood and/or the side effects or oral antidiabetics
- Methotrexate (e.g., Mexate)—Use of methotrexate with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of methotrexate
- Methyldopa (e.g., Aldomet)—Use of methyldopa with sulfapyridine may increase the chance of side effects affecting the liver and/or the blood
- Phenytoin (e.g., Dilantin)—Use of phenytoin with sulfapyridine may increase the chance of side effects affecting the liver and/or the side effects of phenytoin
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| Toxicity |
ORL-RAT 15800 mg/Kg |
| Organisms Affected |
Not Available |
| Chemical IUPAC Name |
4-amino-N-pyridin-2-yl-benzenesulfonamide |
| Chemical Formula |
C11H11N3O2S |
| Molecular Weight |
249.29 g/mol |
| Smiles String |
C1=CC=NC(=C1)NS(=O)(=O)C2=CC=C(C=C2)N |
| Melting Point |
192 °C |
| Water Solubility |
268 mg/L |
| State |
Solid |
| LogP/Hphobicity |
2.384 |
| Isoelectric Point |
8.43 |
| Biotransformation |
Hepatic |
| Half Life |
6-14 hours. |
| Protein Binding [%] |
~50% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Sulfapyridine.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00491 |
| CAS Registry Number |
144-83-2 |
| KEGG Compound ID |
D02434 |
| PubChem ID |
SID:152111 |
| PharmGKB ID |
PA451546 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
1944827
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