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Sulfanilamide
drug data and news
Sulfanilamide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Sulfanilamide | ||
| Brand Names/Synonyms | 1162 F; A-349; AVC; Albexan; Albosal; Ambeside; Antistrept; Astreptine; Astrocid; Avc; Bacteramid; Bactesid; Collomide; Colsulanyde; Copticide; Deseptyl; Desseptyl; Dipron; Ergaseptine; Erysipan; Estreptocida; Exoseptoplix; F 1162; Fourneau 1162; Gerison; Gombardol; HSDB 223; Infepan; Lusil; Lysococcine; NSC 7618; Neococcyl; Orgaseptine; P-Aminobenzenesulfamide; P-Aminobenzenesulfonamide; P-Aminobenzenesulfonylamide; P-Aminobenzensulfonamide; P-Aminophenylsulfonamide; P-Anilinesulfonamide; P-Sulfamidoaniline; P-Sulfamoylaniline; PABS; Prontalbin; Prontosil Album; Prontosil I; Prontosil White; Prontylin; Pronzin Album; Proseptal; Proseptine; Proseptol; Pysococcine; Rubiazol A; Sanamid; Septamide Album; Septanilam; Septinal; Septolix; Septoplex; Septoplix; Solfanilamide [Dcit]; Stopton Album; Stramid; Strepamide; Strepsan; Streptagol; Streptamid; Streptamin; Streptasol; Streptocid; Streptocid Album; Streptocide; Streptocide White; Streptocidum; Streptoclase; Streptocom; Streptol; Strepton; Streptopan; Streptosil; Streptozol; Streptozone; Streptrocide; Sulfamidyl; Sulfamine; Sulfana; Sulfanalone; Sulfanidyl; Sulfanil; Sulfanilamide; Sulfanilamide Vaginal Cream; Sulfanilimidic Acid; Sulfocidin; Sulfocidine; Sulfonamide; Sulfonamide P; Sulfonylamide; Sulphanilamide; Sulphanilamide Extra Pure; Sulphanilamide Gr; Sulphonamide; Therapol; Tolder; White Streptocide | ||
| Indication | For the treatment if vaginitis and vulvovaginitis | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Sulfanilamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. | ||
| Mechanism Of Action | Sulfanilamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. | ||
| Sulfanilamide News (When available) |
Government Accountability Office Report Highly Critical of FDA Is ... Apr 24, 2006 In Latest Drug Scandal, Ketek’s Safety and FDA Approval Are ... May 2, 2006 | ||
| Dosage Forms | LIQUID; PELLET; TABLET | ||
| Drug_Category | Anti-bacterial Agents; Homeopathic Agents; ATC:J01EB06 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Sulfanilamide: This medicine is generally safe with other medications, but patient should consult doctor or pharmacist if patient is taking a blood thinner (anticoagulant), cyclosporin, phenytoin, or methotrexate. | ||
| Toxicity | ORL-MUS LD50 3700 mg kg-1; IPR-MUS LD50 930 mg kg-1; IVN-MUS LD50 621 mg kg-1; ORL-RBT LD50 1300 mg kg-1; SCU-MUS LDLO 2500 mg kg-1. Side effects include itching, burning, skin rash, redness, swelling, or other sign of irritation not present before use of this medicine and long-term use of sulfonamides may cause cancer of the thyroid gland. | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | 4-aminobenzenesulfonamide | ||
| Chemical Formula | C6H8N2O2S | ||
| Molecular Weight | 172.206 g/mol | ||
| Smiles String | C1=CC(=CC=C1N)S(=O)(=O)N | ||
| Melting Point | 165.5 °C | ||
| Water Solubility | 7500 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | -0.201 | ||
| Isoelectric Point | 10.6 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Sulfanilamide.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00438 | ||
| CAS Registry Number | 63-74-1 | ||
| KEGG Compound ID | C07458 | ||
| PubChem ID | SID:9661 | ||
| PharmGKB ID | PA451545 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2236620 |
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