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Sulfadiazine
drug data and news
Sulfadiazine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Sulfadiazine | ||
| Brand Names/Synonyms | A-306; Adiazin; Adiazine; Coco-Diazine; Cocodiazine; Codiazine; Cremodiazine; Cremotres; Debenal; Deltazina; Diazin; Diazolone; Diazovit; Diazyl; Eskadiazine; Honey Diazine; Lantrisul; Lipo-Diazine; Lipo-Levazine; Liquadiazine; Metha-Meridiazine; Microsulfon; Neazine; Neotrizine; Palatrize; Pecta-Diazine, Suspension; Piridisir; Pirimal; Pyrimal; Quadetts; Quadramoid; RP 2616; S. N. 112; SDA; Sanodiazine; Sildaflo; Silvadene; Spofadrizine; Ssd; Sterazine; Sulfa-Triple #2; Sulfacombin; Sulfadiazene; Sulfadiazin; Sulfadiazine; Sulfaloid; Sulfanilamidopyrimidine; Sulfapirimidin; Sulfapyrimidin; Sulfapyrimidine; Sulfatryl; Sulfazin; Sulfazine; Sulfolex; Sulfonamides Duplex; Sulfonsol; Sulfose; Sulphadiazine; Terfonyl; Theradiazine; Thermazene; Tri-Sulfameth; Trifonamide; Triple Sulfa; Triple Sulfas; Triple Sulfoid; Trisem; Trisulfapyrimidine, Oral Suspension; Truozine | ||
| Indication | For the treatment of rheumatic fever and meningococcal meningitis | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Sulfadiazine is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. | ||
| Mechanism Of Action | Sulfadiazine is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), a substrate of the enzyme dihydropteroate synthetase. The inhibited reaction is necessary in these organisms for the synthesis of folic acid. | ||
| Sulfadiazine News (When available) |
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| Dosage Forms | CREAM | ||
| Drug_Category | Antiprotozoals; Anti-Infectives; Anti-Infectives; ATC:D06BA01; ATC:J01EC02 | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Not Available | ||
| Chemical IUPAC Name | 4-amino-N-pyrimidin-2-yl-benzenesulfonamide | ||
| Chemical Formula | C10H10N4O2S | ||
| Molecular Weight | 250.278 g/mol | ||
| Smiles String | C1=CN=C(N=C1)NS(=O)(=O)C2=CC=C(C=C2)N | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Solid | ||
| LogP/Hphobicity | 1.883 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Sulfadiazine.html http://www.rxlist.com/cgi/generic3/silversulf.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00190 | ||
| CAS Registry Number | 68-35-9 | ||
| KEGG Compound ID | C07658 | ||
| PubChem ID | SID:9860 | ||
| PharmGKB ID | PA451539 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2170310 |
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