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Sulfacetamide
drug data and news
Sulfacetamide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Sulfacetamide | ||
| Brand Names/Synonyms | A-500; Acetocid; Acetosulfamin; Acetosulfamine; Ak-Sulf; Albamine; Albucid; Alesten; Bleph-10; Bleph-10 Liquifilm; Cetamide; Formosulfacetamide; Gyne-Sulf; I-Sulfacet; Isopto Cetamide; Isopto-Cetamide; Klaron; N'-Acetylsulfanilamide; N-Acetylsulfanilamide; N-Acetylsulfanilamine; N-Sulfanilylacetamide; N-Sulphanilylacetamide; Oclucid; Ocusulf-10; Op-Sulfa 30; Ophthacet; Ophthel-S; P-Aminobenzenesulfonacetamide; P-Aminobenzenesulfonoacetamide; Region; Sebizon; Sodium Sulamyd; Sodium Sulfacetamide; Steramide; Steri-Units Sulfacetamide; Sulamyd; Sulf-10; Sulf-15; Sulfacel-15; Sulfacet; Sulfacetamide; Sulfacetamide Sodium; Sulfacetamide Sodium Anhydrous; Sulfacetamide Sodium Usp; Sulfacetimide; Sulfacyl; Sulfair; Sulfair 10; Sulfair 15; Sulfair Forte; Sulfair-15; Sulfamide; Sulfanilacetamide; Sulfanilazetamid; Sulfex; Sulphacetamide; Sulphacetamide Sodium; Sulphasil; Sulten-10; Sultrin; Triple Sulfa; Trysul; Urosulfon; Urosulfone; Vagilia | ||
| Indication | For the treatment of bacterial vaginitis, keratitis, acute conjunctivitis, blepharitis | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Sulfacetamide is a sulfonamide antibiotic. The sulfonamides are synthetic bacteriostatic antibiotics with a wide spectrum against most gram-positive and many gram-negative organisms. However, many strains of an individual species may be resistant. Sulfonamides inhibit multiplication of bacteria by acting as competitive inhibitors of p-aminobenzoic acid in the folic acid metabolism cycle. Bacterial sensitivity is the same for the various sulfonamides, and resistance to one sulfonamide indicates resistance to all. Most sulfonamides are readily absorbed orally. However, parenteral administration is difficult, since the soluble sulfonamide salts are highly alkaline and irritating to the tissues. The sulfonamides are widely distributed throughout all tissues. High levels are achieved in pleural, peritoneal, synovial, and ocular fluids. Although these drugs are no longer used to treat meningitis, CSF levels are high in meningeal infections. Their antibacterial action is inhibited by pus. | ||
| Mechanism Of Action | Sulfacetamide is a competitive inhibitor of bacterial para-aminobenzoic acid (PABA), an essential component for bacterial growth (according to the Woods-Fildes theory). The inhibited reaction is necessary in these organisms for the synthesis of folic acid. | ||
| Sulfacetamide News (When available) |
Medicis Announces FDA Approval of SOLODYN -- minocycline HCl, USP ... May 8, 2006 | ||
| Dosage Forms | DROPS; LIQUID; OINTMENT | ||
| Drug_Category | Anti-Infectives Agents, Local; Anti-Infectives Agents, Urinary; Anti-bacterial Agents; ATC:S01AB04 | ||
| Absorption | Not Available | ||
| Interactions |
Interactions for Sulfacetamide: Sulfacetamide preparations are incompatible with silver preparations. | ||
| Toxicity | Oral LD50 Mouse : 16500 mg/kg. Side effects include moderate to severe erythema (redness) and moderate edema (raised kin), nausea, vomiting, headache, dizziness, tiredness. Higher exposure causes unconsciousness. | ||
| Organisms Affected | Enteric bacteria and other eubacteria | ||
| Chemical IUPAC Name | N-acetyl-4-amino-benzenesulfonamide | ||
| Chemical Formula | C8H10N2O3S | ||
| Molecular Weight | 214.243 g/mol | ||
| Smiles String | CC(=O)NS(=O)(=O)C1=CC=C(C=C1)N | ||
| Melting Point | 183 °C | ||
| Water Solubility | 1.25E+004 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 0.201 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Not Available | ||
| Half Life | 7-12.8 hours | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/ava1674.shtml http://www.drugs.com/cons/Sulfacetamide.html http://www.rxlist.com/cgi/generic3/plexion.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00452 | ||
| CAS Registry Number | 144-80-9 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | SID:152109 | ||
| PharmGKB ID | PA451536 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 838934 |
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