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Streptomycin
drug data and news
Streptomycin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Streptomycin
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| Brand Names/Synonyms |
Amikin; G-Mycin; Garamycin; Jenamicin; Kantrex; Nebcin; Netromycin; Streptomycin; Streptomycin Sesquisulfate Hydrate; Streptomycin Sulfate; Streptomycin Sulphate; Streptomycin a Sulfate; Streptomycin, Sulfate Salt |
| Indication |
For the treatment of Tuberculosis |
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Description |
Not Available |
| Pharmacology |
Streptomycin is an aminoglycoside antibiotic. Aminoglycosides work by binding to the bacterial 30S ribosomal subunit, causing misreading of t-RNA, leaving the bacterium unable to synthesize proteins vital to its growth. Aminoglycosides are useful primarily in infections involving aerobic, Gram-negative bacteria, such as Pseudomonas, Acinetobacter, and Enterobacter. In addition, some mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Infections caused by Gram-positive bacteria can also be treated with aminoglycosides, but other types of antibiotics are more potent and less damaging to the host. In the past the aminoglycosides have been used in conjunction with penicillin-related antibiotics in streptococcal infections for their synergistic effects, particularly in endocarditis. Aminoglycosides are mostly ineffective against anaerobic bacteria, fungi and viruses. |
| Mechanism Of Action |
Aminoglycosides like Streptomycin "irreversibly" bind to specific 30S-subunit proteins and 16S rRNA. Specifically Streptomycin binds to four nucleotides of 16S rRNA and a single amino acid of protein S12. This interferes with decoding site in the vicinity of nucleotide 1400 in 16S rRNA of 30S subunit. This region interacts with the wobble base in the anticodon of tRNA. This leads to interference with the initiation complex, misreading of mRNA so incorrect amino acids are inserted into the polypeptide leading to nonfunctional or toxic peptides and the breakup of polysomes into nonfunctional monosomes. |
Streptomycin News
(When available) |
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| Dosage Forms |
POWDER FOR SOLUTION |
| Drug_Category |
Anti-bacterial Agents; Aminoglycosides; ATC:A07AA04; ATC:J01GA01; ATC:S01AA15 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Oral rat LD50: 430 mg/kg (Streptomycin Sulfate).Side effect include nausea, vomiting, and vertigo, paresthesia of face, rash; fever, urticaria, angioneurotic edema, and eosinophilia. |
| Organisms Affected |
Enteric bacteria and other eubacteria |
| Chemical IUPAC Name |
5-(2,4-diguanidino-3,5,6-trihydroxy-cyclohexoxy)-4-[4,5-dihydroxy-6-(hydroxymethyl)-3-methylamino-tetrahydropyran-2-yl]oxy-3-hydroxy-2-methyl-tetrahydrofuran-3-carbaldehyde |
| Chemical Formula |
C21H39N7O12 |
| Molecular Weight |
581.574 g/mol |
| Smiles String |
CC1C(C(C(O1)OC2C(C(C(C(C2O)O)N=C(N)N)O)N=C(N)N)OC3C(C(C(C(O3)CO)O)O)NC)(C=O)O |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
-8.005 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Streptomycin.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00412 |
| CAS Registry Number |
57-92-1 |
| KEGG Compound ID |
C00413 |
| PubChem ID |
SID:3703 |
| PharmGKB ID |
PA451512 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
2243660
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