Serum albumin drug data and news

Serum albumin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name

Serum albumin

Brand Names/Synonyms

Serum albumin precursor; Optison

Indication

For treatment of severe blood loss, hypervolemia, hypoproteinemia

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Description

A sterile non-pyrogenic suspension of microspheres of human serum albumin with perflutren (a highly fluorinated small molecule) for contrast enhancement during indicated ultrasound imaging procedures.

Pharmacology

Regulates the colloidal osmotic pressure of blood. It is used to increase the circulating plasma volume, thereby reducing hemoconcentration and blood viscosity. Also used as a transport protein that binds naturally occurring, therapeutic and toxic materials in circulation.

Mechanism Of Action

Serum albumin acts as a high molecular weight, very soluble osmolyte

Serum albumin News
(When available)

Risk Assessment for and Strategies To Reduce Perioperative ... Apr 17, 2006
Recommendation 3: A low serum albumin level (<35 g/L) is a powerful marker of increased risk for postoperative pulmonary complications and should be measured ... - Annals of Internal Medicine

Immunomedics and IBC Pharmaceuticals Report on a Novel Protein ... Apr 25, 2006
Suitable components for this technology include antibody fragments, peptide haptens, polyethylene glycols, human serum albumin, cytokines, DNA vaccines, small ... - Yahoo! News (press release)

Immunomedics and IBC Pharmaceuticals Report on a Novel Protein ... Apr 26, 2006
..."Suitable components for this technology include antibody fragments, peptide haptens, polyethylene glycols, human serum albumin, cytokines, DNA vaccines, small ... - GenomicsProteomics.com (press release),

Paclitaxel efficacy enhanced by novel compound 73R Apr 20, 2006
...at Abbott Laboratories. "The dominant component of serum deactivation was identified as domain III of human serum albumin (HSA).". - Therapeutics Daily (subscription) (press release),

Optimizing Catheter Positioning Improves Drug Distribution of ... Apr 26, 2006
...study with intracerebral CED of the tumor targeted cytotoxin, cintredekin besudotox (IL13-PE38QQR), co-infused with 123I-labeled human serum albumin (123I-HSA ... - Genetic Engineering News,

RCT Hosting October 2006 Conference on the Future of Pichia ... Apr 24, 2006
...cost. Examples of pharmaceutical proteins made in Pichia include hepatitis B vaccine, insulin, interferons and human serum albumin. ... - Genetic Engineering News,

Dosage Forms

LIQUID

Drug_Category

Serum substitutes; blood derivatives (16:00.00)

Absorption

Not Available

Interactions

Not Available

Toxicity

Not Available

Organisms Affected

Humans and other mammals

Chemical IUPAC Name

Human serum albumin

Chemical Formula

C2936H4624N786O889S41

Molecular Weight

66472.2

Smiles String

Not Available

Melting Point

62 oC (Flora, K. et al., Biophys J. 75:1084-1096 (1998))

Water Solubility

Not Available

State

Transparent, slightly viscous, aqueous liquid

LogP/Hphobicity

-0.395

Isoelectric Point

5.67

Biotransformation

Not Available

Half Life

Not Available

Protein Binding [%]

Not Available

RxList Link

Not Available>RXlist

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Drug Reference

Not Available

Drug Type

Approved Drug

Accession No

BIOD00101

CAS Registry Number

9048-49-1

KEGG Compound ID

Not Available

PubChem ID

Not Available

PharmGKB ID

Not Available

SwissProt ID

ALBU_HUMAN (P02768)

GenBank ID

M12523

Drug ID Number [DIN]

35408