Sertraline drug data and news

Sertraline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Sertraline
Brand Names/Synonyms Apo-Sertraline; HSDB 7037; Lustral; Sertralina [Spanish]; Sertraline; Sertraline Hydrochloride; Sertralinum [Latin]; Sultamicillin Tosylate; Zoloft
Indication For the treatment of posttraumatic stress disorder, depression, obsessive-compulsive disorder and panic disorder
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Description Not Available
Pharmacology Sertraline, an antidepressant drug similar to citalopram, fluoxetine, and paroxetine, is of the selective serotonin reuptake inhibitor (SSRI) type. Sertraline has one active metabolite and is used to treat depression, obsessive-compulsive disorder (OCD), panic disorder, and post-traumatic stress disorder.
Mechanism Of Action It is believed that sertraline inhibits reuptake of serotonin at the neuronal membrane. SSRIs have less sedative, anticholinergic, and cardiovascular effects than the tricyclic antidepressant drugs because of decreased binding to histamine, acetylcholine, and norepinephrine receptors.
Sertraline News
(When available)

Sertraline for Prevention of Depression Recurrence in Diabetes ...  May 1, 2006
Objective To determine whether maintenance therapy with sertraline hydrochloride prevents recurrence of major depression in patients with diabetes. ... - Archives of General Psychiatry

A Randomized, Placebo-Controlled Trial of Sertraline in the ...  Apr 28, 2006
OBJECTIVE: The authors assessed the efficacy of sertraline in the treatment of night eating syndrome. METHOD: Thirty-four outpatients ... - Am J Psychiatry (subscription)

The Interface of Depression and Dementia  May 13, 2006
Five trials evaluated selective serotonin reuptake inhibitors (sertraline [Zoloft], fluoxetine [Prozac] and citalopram [Celexa]), three evaluated TCAs ... - Psychiatric Times,

Combined Psychotherapy and Pharmacotherapy for Mood and Anxiety ...  May 15, 2006
...(2001). Randomised controlled general practice trial of sertraline, exposure therapy and combined treatment in generalized social phobia. ... sertraline alone. ... - Focus (subscription)

Antidepressant Drug May Prevent Recurrence Of Depression In ...  May 11, 2006
Study participants averaged just over 50 years of age, and all had recovered from an episode of depression following treatment with sertraline (Zoloft®). ... - Medical News Today (press release),

Antidepressant Medication May Prevent Recurring Depression in ...  May 2, 2006
The antidepressant sertraline may reduce the risk of recurrent depression and increase the period of time between episodes of depression in patients with ... - Kansas City infoZine,

Antidepressant Medication May Prevent Recurring Depression in ...  May 3, 2006
CHICAGO, IL -- May 3, 2006 -- The antidepressant sertraline may reduce the risk of recurrent depression and increase the period of time between episodes of ... - DG News

Antidepressant effective for diabetics  May 10, 2006
After their depression was under control, half of the study patients continued to take sertraline while the other half took an inactive placebo. ... - CNN-IBN,

Depressed Seniors Resort to Nursing Homes  May 13, 2006
According to a new study, the antidepressant drug Zoloft (sertraline) may avoid in preventing recurring of depression in diabetics and may also increase the ... - MedIndia,

Zoloft Helps Diabetics Fight Depression  May 4, 2006
THURSDAY, May 4 (HealthDay News) -- The antidepressant drug Zoloft (sertraline) may help prevent recurring depression in people with diabetes and increase the ... - Forbes

Antidepressant Holds Depression at bay for Diabetics  May 2, 2006
...(Ivanhoe Newswire) -- Diabetics who suffer from depression may get long-term relief with the antidepressant sertraline, find researchers who studied the use of ... - Ivanhoe,

Antidepressant Therapy Effective in Diabetics  May 2, 2006
ST, LOUIS, May 2 — For diabetic patients in remission from major depression, maintenance with Zoloft (sertraline) extended the interval before recurrence ... - MedPage Today,

Finding "Hidden" Drug Effects  May 10, 2006
Using this methodology, the researchers profiled the antidepressant sertraline, for example, showing that its profile for certain biochemical pathways was ... - MIT Technology Review,

Health checkup: depression and heart disease  May 3, 2006
Sertraline (Zoloft), a serotonin selective reuptake inhibitor, helps reduce the build-up of clots. Recent research showed that the ... - Rochester Democrat and Chronicle,

Detecting Drugs' Influence  May 12, 2006
The study uncovered previously unknown antiproliferative activities for four of the drugs, including the antidepressant sertraline. ... - Chemical & Engineering News

Self-Mutilation of Fingers After Cervical Spinal Cord Injury  May 9, 2006
He was previously treated with sertraline, 50 mg daily, for anger outbursts, and was also diagnosed, post-MVA, with "anxiety attacks." Family history was ... - Psychosomatics (subscription)

In This Issue  May 2, 2006
...(p. 893) demonstrated a striking response of night eating syndrome to the antidepressant sertraline, a selective serotonin reuptake inhibitor. ... - Am J Psychiatry (subscription)

The Can-SAD Study: A Randomized Controlled Trial of the ...  May 2, 2006
In a larger study (N=187), sertraline in a flexible dose (50–200 mg/day) for 8 weeks was superior to placebo both in improving depression scores and in the ... - Am J Psychiatry (subscription)

Antidepressants extend time to relapse in diabetics  May 2, 2006
NEW YORK (Reuters Health) - Maintenance treatment with the antidepressant sertraline (Zoloft) after a first episode of depression has resolved extends the time ... - Reuters.uk,

Medication may cut depression in diabetics  May 8, 2006
...or type 1, diabetes, who averaged just over 50 years of age, and all had recovered from an episode of depression following treatment with sertraline, or Zoloft ... - United Press International

Booster dose  May 7, 2006
...for the regulated markets. Among the new products that will be produced by Wanbury are sertraline and carvedilol. The company has ... - Economic Times,

Less Anxiety But More Violence?  Apr 30, 2006
...effect is repeatedly noted in the Physicians' Desk Reference for most selective serotonin reuptake inhibitors such as fluoxetine (Prozac) and sertraline (Zoloft ... - Psychiatric Times,

Pfizer Japan Obtains Approval for ZYVOX, Detrusitol, J Zoloft in ...  Apr 24, 2006
J ZOLOFT (sertraline hydrochloride), a selective seretonin reuptke inhibitor developed by Pfizer of the US, is the most prescribed drug for the treatment of ... - Japan Corporate News (press release),

Experts See Need for Further Study of Insomnia and Sleep Aids like ...  Apr 24, 2006
Driver taking 190 ng/mL plus other antidepressants driving southbound in northbound lane; (5) Driver taking 1,000 ng/mL plus Zoloft (sertraline) crashed into a ... - Newsinferno.com,

Popular antidepressants may affect fetus  Apr 20, 2006
The study included SSRIs such as fluoxetine (Prozac) Paroxetine (Paxil) and Sertraline (Zoloft), but the sample size was not large enough to estimate risks for ... - News-Medical.net,

Perrigo Company Reports Third Quarter Fiscal 2006 Financial ...  Apr 27, 2006
...approvals for desoximetasone gel, ciclopirox olamine cream, terconazole vaginal suppositories and a tentative approval for sertraline hydrochloride tablets ... - PR Newswire (press release),

Pfizer profits soar despite slipping revenues  Apr 20, 2006
...loss of US patent protection on two products, antibiotic Zithromax (azithromycin) in the fourth quarter of 2005 and antidepressant Zoloft (sertraline) in the ... - Pharma Times (subscription),

Dosage Forms Tablets and Oral solution
Drug_Category Antidepressants; Selective Serotonin Reuptake Inhibitors (SSRIs); ATC:N06AB06
Absorption The effects of food on the bioavailability of the sertraline tablet and oral concentrate were studied in subjects administered a single dose with and without food. For the tablet, AUC was slightly increased when drug was administered with food but the Cmax was 25% greater, while the time to reach peak plasma concentration (Tmax) decreased from 8 hours post-dosing to 5.5 hours. For the oral concentrate, Tmax was slightly prolonged from 5.9 hours to 7.0 hours with food.
Interactions [an error occurred while processing this directive]Toxicity alopecia, decreased libido, diarrhea, ejaculation disorder, fatigue, insomnia, somnolence and serotonin syndrome LD50=mg/kg(orally in mice)
Organisms Affected Humans and other mammals
Chemical IUPAC Name 4-(3,4-dichlorophenyl)-N-methyl-tetralin-1-amine
Chemical Formula C17H17Cl2N
Molecular Weight 306.229 g/mol
Smiles String CNC1CCC(C2=CC=CC=C12)C3=CC(=C(C=C3)Cl)Cl
Melting Point 243-245°C
Water Solubility 3.5mg/L
State white crystalline powder
LogP/Hphobicity 5.567
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 26 hours
Protein Binding [%] 98%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Sertraline.html
http://www.rxlist.com/cgi/generic/sertral.htm
Drug Type Approved Drug
Accession No APRD00175
CAS Registry Number 79617-96-2
KEGG Compound ID C07246
PubChem ID SID:210738
PharmGKB ID PA451333
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2245749

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