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Sermorelin
drug data and news
Sermorelin drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Sermorelin | ||
| Brand Names/Synonyms | Geref; Geref (Serono Pharma) | ||
| Indication | For treatment of dwarfism, prevention of HIV-induced weight loss | ||
| Sponsored links | Description | Sermorelin acetate is the acetate salt of an amidated synthetic 29-amino acid peptide (GRF 1-29 NH 2 ) that corresponds to the amino-terminal segment of the naturally occurring human growth hormone-releasing hormone (GHRH or GRF) consisting of 44 amino acid residues | |
| Pharmacology | Used in the treatment of children with growth hormone deficiency or growth failure. Geref increases plasma growth hormone (GH) concentration by stimulating the pituitary gland to release GH. Geref is similar to the full-length native hormone (44 residues) in its ability to stimulate GH secretion in humans. | ||
| Mechanism Of Action | Binds to the growth hormone releasing hormone receptor and mimics native GRF in its ability to stimulate growth hormone secretion. | ||
| Sermorelin News (When available) |
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| Dosage Forms | Not Available | ||
| Drug_Category | Anabolic Agents; Hormone replacement | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | Human growth hormone-releasing hormone fragment | ||
| Chemical Formula | C154H253N45O45S1 | ||
| Molecular Weight | 3487 | ||
| Smiles String | Not Available | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | -0.33 | ||
| Isoelectric Point | 9.99 | ||
| Biotransformation | Not Available | ||
| Half Life | 11-12 min | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Sermorelin.html http://www.rxlist.com/cgi/generic2/sermorelin.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00033 | ||
| CAS Registry Number | 86168-78-7 | ||
| KEGG Compound ID | C08192 | ||
| PubChem ID | 10391 | ||
| PharmGKB ID | PA451331 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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