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Secobarbital
drug data and news
Secobarbital drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Secobarbital | ||
| Brand Names/Synonyms | Seconal (TN); Secobarbital (USP); Novosecobarb; Barbosec; Bipanal; Bipinal sodium; CHEMBANK2949; DEA No. 2315; DEA No. 2316; Evronal; Evronal Sodium; Evrronal; HSDB 3182; Hypotrol; Hyptran; Imesonal; Immenoctal; Immenox; Meballymal; Meballymal sodium; Meballymalum; Pramil; Quinalbarbital; Quinalbarbitone; Quinalbarbitone sodium; Quinalspan; Sebar; Seco 8; Secobarbital; Secobarbital Sodium; Secobarbital [USAN:INN]; Secobarbital suppository dosage form; Secobarbitale [DCIT]; Secobarbitalum [INN-Latin]; Secobarbitone; Seconal; Seconal Sodium; Sedutain; Seotal; Sodium Secobarbital; Sodium Seconal; Sodium quinalbarbitone; Somosal; Synate; Trisomnin; (+/-)-Secobarbital; EINECS 200-982-2; Secobarbital (USP); Seconal (TN) | ||
| Indication | For the Short-term treatment of intractable insomnia for patients habituated to barbiturates | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Secobarbital, a barbiturate, is used for the induction of anesthesia prior to the use of other general anesthetic agents and for induction of anesthesia for short surgical, diagnostic, or therapeutic procedures associated with minimal painful stimuli. Little analgesia is conferred by barbiturates; their use in the presence of pain may result in excitation. | ||
| Mechanism Of Action | Secobarbital binds at a distinct binding site associated with a Cl- ionopore at the GABAA receptor, increasing the duration of time for which the Cl- ionopore is open. The post-synaptic inhibitory effect of GABA in the thalamus is, therefore, prolonged. | ||
| Secobarbital News (When available) |
The perils of self-prescription May 5, 2006 | ||
| Dosage Forms | CAPSULE | ||
| Drug_Category | Hypnotics and Sedatives; Adjuvants; Barbiturates; ATC:N05CA06 | ||
| Absorption | Not Available | ||
| Interactions | Interations Barbiturates may decrease the effectiveness of oral contraceptives, certain antibiotics, quinidine, theophylline, corticosteroids, anticoagulants, and beta blockers. | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | 5-(1-methylbutyl)-5-prop-2-enyl-hexahydropyrimidine-2,4,6-trione | ||
| Chemical Formula | C12H18N2O3 | ||
| Molecular Weight | 238.283 g/mol | ||
| Smiles String | CCCC(C)C1(C(=O)NC(=O)NC1=O)CC=C | ||
| Melting Point | 100 °C | ||
| Water Solubility | 550 mg/L | ||
| State | Solid | ||
| LogP/Hphobicity | 1.879 | ||
| Isoelectric Point | 7.8 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Secobarbital.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00497 | ||
| CAS Registry Number | 76-73-3 | ||
| KEGG Compound ID | C07244 | ||
| PubChem ID | SID:9453 | ||
| PharmGKB ID | PA451313 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 21032 |
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