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Satumomab Pendetide
drug data and news
Satumomab Pendetide drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Satumomab Pendetide
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| Brand Names/Synonyms |
OncoScint; OncoScint (Cytogen Corp, Lonza Biologics) |
| Indication |
For diagnosis of extrahepatic malignant cancers |
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Description |
Tumor associated glycoprotein (TAG) 72 (B72.3) monoclonal antibody conjugated with Indium 111 for radioimaging colon tumors. |
| Pharmacology |
Binds to the tumor associated glycoprotein 72 antigen, which is a cell surface protein generally over-expressed in colorectal cancers. The radioactive Indium 111, which is covalently attached to the antibody, allows radiodiagnostic detection of TAG-72 expressing cells and tumors |
| Mechanism Of Action |
Binds selectively to cell-surface TAG-72 expressed on colorectal tumors. |
Satumomab Pendetide News
(When available) |
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| Dosage Forms |
Not Available |
| Drug_Category |
Imaging Agent |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Not Available |
| Chemical IUPAC Name |
Murine anti-TAG72 antibody conjugated with Indium 111 |
| Chemical Formula |
C6268H9708N1666O1971S48 >Light chain 1 B72.3 (murine) >Heavy chain 2 B72.3 (murine) >Light chain 2 B72.3 (murine) |
| Molecular Weight |
141478.9 |
| Smiles String |
Not Available |
| Melting Point |
61 oC (FAB fragment), 71 oC (whole mAb) - Vermeer, A.W.P. & Norde, W., Biophys. J. 78:394-404 (2000). |
| Water Solubility |
Not Available |
| State |
Transparent, slightly viscous, aqueous liquid |
| LogP/Hphobicity |
-0.427 |
| Isoelectric Point |
7.02 |
| Biotransformation |
Most likely removed by opsonization via the reticuloendothelial system or by human antimurine antibody production |
| Half Life |
0.8 hours (mammalian reticulocytes, in vitro) |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
Not Available |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00108 |
| CAS Registry Number |
138955-26-7 |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
PA10321 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
Not Available
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