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Sargramostim
drug data and news
Sargramostim drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Sargramostim | ||
| Brand Names/Synonyms | Granulocyte-macrophage colony-stimulating factor precursor;GM-CSF;Colony-stimulating factor;CSF;Sargramostim;Molgramostin; Leukine (Berlex Laboratories Inc; Immunex); Leucomax (Novartis) | ||
| Indication | Increases leukocyte production, for treatment in cancer and bone marrow transplant | ||
| Sponsored links | Description | Human, recombinant GM-CSF, expressed in yeast. Glycoprotein that is 127 residues. Substitution of Leu23 leads to a difference from native protein. | |
| Pharmacology | Used in the treatment of bone marrow transplant recipients or those exposed to chemotherapy an recovering from acut myelogenous leukemia, Leukine or GM-CSF is a hematopoietic growth factor which stimulates the survival, clonal expansion (proliferation) and differentiation of hematopoietic progenitor cells. GM-CSF is also capable of activating mature granulocytes and macrophages. After a bone marrow transplant or chemotherapy, patients have a reduced capacity to produce red and white blood cells. Supplementing them with external sources of GM-CSF helps bring the level of neutrophils back to normal so that they can better fight infections. | ||
| Mechanism Of Action | Leukine binds to the Granulocyte-macrophage colony stimulating factor receptor (GM-CSF-R-alpha or CSF2R) which stimulates a JAK2 STAT1/STAT3 signal transduction pathway. This leads to the production of hemopoietic cells and neutrophils | ||
| Sargramostim News (When available) |
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| Dosage Forms | Not Available | ||
| Drug_Category | Immunomodulatory Agents; Antineoplastic Agents; Anti-infective Agents | ||
| Absorption | Not Available | ||
| Interactions | Not Available | ||
| Toxicity | Not Available | ||
| Organisms Affected | Not Available | ||
| Chemical IUPAC Name | Human granulocyte macrophage colony stimulating factor | ||
| Chemical Formula | C639H1006N168O196S8 | ||
| Molecular Weight | 14434.5 | ||
| Smiles String | Not Available | ||
| Melting Point | Not Available | ||
| Water Solubility | Not Available | ||
| State | Transparent, slightly viscous, aqueous liquid | ||
| LogP/Hphobicity | Not Available | ||
| Isoelectric Point | 5.05 | ||
| Biotransformation | Not Available | ||
| Half Life | Not Available | ||
| Protein Binding [%] | Not Available | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Sargramostim.html http://www.rxlist.com/cgi/generic/sargramostim.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | BIOD00035 | ||
| CAS Registry Number | 83869-56-1 | ||
| KEGG Compound ID | Not Available | ||
| PubChem ID | Not Available | ||
| PharmGKB ID | PA451306 | ||
| SwissProt ID | CSF2_HUMAN (P04141) | ||
| GenBank ID | M13207 | ||
| Drug ID Number [DIN] | Not Available |
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