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Saquinavir
drug data and news
Saquinavir drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Saquinavir | ||
| Brand Names/Synonyms | Fortovase; Invirase; ROC; SAQUINAVIR; SQV; Saquinavir; Saquinavir Mesylate; Saquinavir [Usan] | ||
| Indication | HIV-1 with advanced immunodeficiency together with antiretroviral nucleoside analogues | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Saquinavir is a protease inhibitor with activity against Human Immunodeficiency Virus Type 1 (HIV-1). Protease inhibitors block the part of HIV called protease. HIV-1 protease is an enzyme required for the proteolytic cleavage of the viral polyprotein precursors into the individual functional proteins found in infectious HIV-1. Saquinavir binds to the protease active site and inhibits the activity of the enzyme. This inhibition prevents cleavage of the viral polyproteins resulting in the formation of immature non-infectious viral particles. Protease inhibitors are almost always used in combination with at least two other anti-HIV drugs. | ||
| Mechanism Of Action | Saquinavir inhibits the HIV viral proteinase enzyme which prevents cleavage of the gag-pol polyprotein, resulting in noninfectious, immature viral particles. | ||
| Saquinavir News (When available) |
International Approvals: Invirase and Remicade May 15, 2006 HIV-positive people with higher viral load have increased risk of ... Apr 23, 2006 Roche Women Honored as 2006 TWIN Awardees Apr 28, 2006 | ||
| Dosage Forms | INVIRASE (saquinavir mesylate) capsules and FORTOVASE (saquinavir) soft gelatin capsules | ||
| Drug_Category | Anti-HIV Agents; Anti-HIV Agents; ATC:J05AE01 | ||
| Absorption | Absolute bioavailability of saquinavir administered as INVIRASE averaged 4% | ||
| Interactions | [an error occurred while processing this directive]Toxicity | probably experience pain in the throat | |
| Organisms Affected | Human immunodeficiency virus | ||
| Chemical IUPAC Name | N-[1-benzyl-2-hydroxy-3-[3-(tert-butylcarbamoyl)-1,2,3,4,4a,5,6,7,8,8a-decahydroisoquinolin-2-yl]-propyl]-2-quinolin-2-ylcarbonylamino-butanediamide | ||
| Chemical Formula | C38H50N6O5 | ||
| Molecular Weight | 670.841 g/mol | ||
| Smiles String | CC(C)(C)NC(=O)C1CC2CCCCC2CN1CC(C(CC3=CC=CC=C3)NC(=O)C(CC(=O)N)NC(=O)C4=NC5=CC=CC=C5C=C4)O | ||
| Melting Point | 349.84 | ||
| Water Solubility | insoluble | ||
| State | white to off-white, very fine powder | ||
| LogP/Hphobicity | 3.645 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | Not Available | ||
| Protein Binding [%] | 98% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.drugs.com/cons/Saquinavir.html http://www.rxlist.com/cgi/generic/saquin.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00623 | ||
| CAS Registry Number | 127779-20-8 | ||
| KEGG Compound ID | C07243 | ||
| PubChem ID | SID:197032 | ||
| PharmGKB ID | PA451305 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2239083 |
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