Salmeterol drug data and news

Salmeterol drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Salmeterol
Brand Names/Synonyms Aeromax; Arial; Astmerole; CHEMBANK1801; SEREVENT; Salmetedur; Salmeterol; Salmeterol Xinafoate; Salmeterol [Usan:Ban:Inn]; Salmeterolum [Latin]; Serevent; [Usan:Ban:Inn]
Indication For the treatment of Asthma and chronic obstructive pulmonary disease (COPD).
Sponsored links
Description Not Available
Pharmacology Salmeterol, a highly selective beta(2)-agonist, is used to treat asthma and to prevent bronchospasm in patients with reversible obstructive airway disease.
Mechanism Of Action Salmeterol's long, lipophilic side chain binds to exosites near beta(2)-receptors in the lungs and on bronchiolar smooth muscle, allowing the active portion of the molecule to remain at the receptor site, continually binding and releasing. Beta(2)-receptor stimulation in the lung causes relaxation of bronchial smooth muscle, bronchodilation, and increased bronchial airflow.
Salmeterol News
(When available)

GSK Receives Positive Opinion From CHMP on Seretide (Salmeterol ...  May 3, 2006
...received a positive opinion from the European Committee for Medicinal Products for Human Use (CHMP) on dosing of Seretide™ (salmeterol/fluticasone propionate ... - DG News

Don’t panic if your asthma worsens over your lifetime  May 13, 2006
Of the medications you mentioned, only Advair (fluticasone/salmeterol combination inhaler), which contains an inhaled corticosteroid, is an asthma medication. ... - Fort Wayne Journal Gazette,

Kos and SkyePharma Sign Exclusive License Agreement for the ...  May 7, 2006
Bycontrast salmeterol, the bronchodilator used in GlaxoSmithKline'sAdvair(R)/Seretide(R), also provides 12 hours of bronchodilation, butneeds up to 30 minutes ... - Finanzen.net,

Asthmatx: a New Approach to Asthma  Apr 19, 2006
...consists of relatively high doses of inhaled corticosteroids (ICS) in combination with a long-acting beta-2 agonist (LABA) such as salmeterol or formoterol. ... - International News Service,

GlaxoSmithKline gets positive EU opinion on Seretide dosing  May 3, 2006
...has received a positive opinion from the European Committee for Medicinal Products for Human Use (CHMP) on dosing of Seretide (salmeterol/fluticasone propionate ... - MarketWatch

SkyePharma and Kos Announce Exclusive Licence Agreement for ...  May 7, 2006
By contrast salmeterol, the bronchodilator used in GlaxoSmithKline's Advair/Seretide, also provides 12 hours of bronchodilation but needs up to 30 minutes ... - Yahoo! News (press release)

SkyePharma seals Flutiform pact with Kos  May 8, 2006
Flutiform will compete in the US marketplace with GlaxoSmithKline's Symbicort (salmeterol and fluticasone), which shrugged off a black box safety warning to ... - Pharma Times (subscription),

Viapaed Study In Children And Adolescents With Asthma  Apr 21, 2006
Children who remain symptomatic while inhaling 100 µg fluticasone (FP) twice daily shall be randomised to receive the salmeterol/ fluticasone combination ... - Community Dispatch (press release)

‘Patients can lead asthma-free lives’  Apr 29, 2006
Patients treated with Seretide (a new combination therapy with Fluticasone propionate and Salmeterol combined in one inhaler) showed a remarkable improvement ... - Daily Times,

First Quarter Report 2006: Schwarz Pharma with a Good Start  Apr 25, 2006
This growth is mainly attributable to sales of the antiasthmatic drug Atmadisc® (fluticasone/ salmeterol), which was up 11.7% to €11.8 million and the ... - PharmaLive.com (press release),

Asthma Treatment, Finally An Effective Drug-free Alternative  Apr 19, 2006
Drug company GlaxoSmithKline's study of Salmeterol, the medication used in Advair and another Glaxo asthma product, Serevent appeared to trigger fatal attacks ... - Emediawire (press release),

SkyePharma PLC - Preliminary Results Announcement for the Year ...  Apr 19, 2006
By contrast salmeterol, the bronchodilator used in GlaxoSmithKline's Advair/Seretide, is also a twice-daily product but has the drawback of needing 30-45 ... - PR Newswire (press release),

GSK sees better-than-expected 1Q  Apr 28, 2006
...up 44% to £366 million, and another pleasing performance from its number one asthma offering Seretide/Advair (fluticasone plus salmeterol), which rose 12% to ... - Pharma Times (subscription),

COPD patients show reduced bronchial inflammation after ...  Apr 20, 2006
The combination of two existing clinical treatments, salmeterol and fluticasone propionate, can significantly reduce inflammatory cells in the airways of ... - Therapeutics Daily (subscription) (press release),

Dosage Forms METERED-DOSE (AEROSOL); POWDER
Drug_Category Bronchodilator Agents; Sympathomimetic; Adrenergic beta-Agonists;
Absorption Because of the small therapeutic dose, systemic levels of salmeterol are low or undetectable after inhalation of recommended doses (50 mcg of salmeterol inhalation powder twice daily). Following chronic administration of an inhaled dose of 50 mcg of salmeterol inhalation powder twice daily, salmeterol was detected in plasma within 5 to 45 minutes in 7 patients with asthma; plasma concentrations were very low, with mean peak concentrations of 167 pg/mL at 20 minutes and no accumulation with repeated doses.
Interactions [an error occurred while processing this directive]Toxicity seizures, angina, hypertension or hypotension, tachycardia with rates up to 200 beats/min, arrhythmias, nervousness, headache, tremor, muscle cramps, dry mouth, palpitation, nausea, dizziness, fatigue, malaise, and insomnia; LD50=2000 mg/kg (rats)(orally in mice)
Organisms Affected Humans and other mammals
Chemical IUPAC Name 2-(hydroxymethyl)-4-[1-hydroxy-2-[6-(4-phenylbutoxy)hexylamino]ethyl]-phenol
Chemical Formula C25H37NO4
Molecular Weight 415.566 g/mol
Smiles String C1=CC=C(C=C1)CCCCOCCCCCCNCC(C2=CC(=C(C=C2)O)CO)O
Melting Point 75.5-76.5 °C
Water Solubility Sparingly soluble
State Solid, white to off-white powder
LogP/Hphobicity 5.022
Isoelectric Point Not Available
Biotransformation Hepatic, metabolized by hydroxylation via CYP3A4
Half Life 5.5 hours
Protein Binding [%] 96%
RxList Link RXlist
Sponsored links
Drug Reference http://www.drugs.com/cons/Salmeterol.html
http://www.rxlist.com/cgi/generic/salmeterol.htm
http://www.pharmgkb.org/views/index.jsp?objId=
Drug Type Approved Drug
Accession No APRD00277
CAS Registry Number 89365-50-4
KEGG Compound ID C07241
PubChem ID SID:205141
PharmGKB ID PA451300
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2231129

Home | About | Cancers | Treatment | Medications
Copyright onconews.org 2005.
All Rights Reserved.
Google
 
Web onconews.org