| Generic name |
Ritodrine
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| Brand Names/Synonyms |
BRN 2388728; DU-21220; RITODRINE; Ritodrina; Ritodrina [Inn-Spanish]; Ritodrine; Ritodrine Hcl; Ritodrine Hydrochloride; Ritodrine [Usan:Ban:Inn]; Ritodrinium; Ritodrinium [Inn-Latin]; Yutopar; Yutopar S.R |
| Indication |
For the treatment and prophylaxis of premature labour |
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Description |
Not Available |
| Pharmacology |
Beta-2 adrenergic receptors are located at sympathetic neuroeffector junctions of many organs, including uterus. Ritodrine is beta-2 adrenergic agonist. It stimulates beta-2 adrenergic receptor, increases cAMP level and decreases intracellular calcium concentration. The decrease of calcium concentration leads to a relaxation of uterine smooth muscle. |
| Mechanism Of Action |
Ritodrine is beta-2 adrenergic agonist. It binds to beta-2 adrenergic receptors on outer membrane of myometrial cell, activates adenyl cyclase to increase the level of cAMP which decreases intracellular calcium and leads to a decrease of uterine contractions. |
Ritodrine News
(When available) |
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| Dosage Forms |
Solution for IV; Capsule (Extended-Release); Tablet; Intramuscular injection |
| Drug_Category |
Adrenergic beta-Agonists; Tocolytic Agents; Sympathomimetic; ATC:G02CA01 |
| Absorption |
Not Available |
| Interactions |
Interactions for Ritodrine:
Ritodrine may interact with the folloing medications:
-Anesthetics: may potentiate the hypotensive effects
-Diazoxide, parenteral
-Magnesium sulfate
-Meperidine
-sympathomimetic amines: may be additive
-Beta-adrenergic antagonists: inhibit Ritodrine
-Corticosteroids: may cause pulmonary edema
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| Toxicity |
LD50=64mg/kg (mice, IV); LD50=540 mg/kg (mice, oral); LD50=85 mg/kg (rat, IV) |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
4-[2-[2-hydroxy-2-(4-hydroxyphenyl)-1-methyl-ethyl]aminoethyl]phenol |
| Chemical Formula |
C17H21NO3 |
| Molecular Weight |
287.354 g/mol |
| Smiles String |
CC(C(C1=CC=C(C=C1)O)O)NCCC2=CC=C(C=C2)O |
| Melting Point |
88-90 °C |
| Water Solubility |
Complete |
| State |
Solid |
| LogP/Hphobicity |
2.588 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Hepatic, by both the mother and fetus |
| Half Life |
1.7-2.6 hours |
| Protein Binding [%] |
~56% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Ritodrine.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00541 |
| CAS Registry Number |
26652-09-5 |
| KEGG Compound ID |
C07239 |
| PubChem ID |
SID:9448 |
| PharmGKB ID |
PA451258 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
550140
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