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Ribavirin and Alfa Interferon (Intron A)
drug data and news
Ribavirin and Alfa Interferon (Intron A) drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Ribavirin and Alfa Interferon (Intron A)
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| Brand Names/Synonyms |
Interferon alpha-2 precursor;Interferon alpha-A;LeIF A; Rebetron (Schering-Plough) |
| Indication |
For treatment of Hepatitis C |
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Description |
Not Available |
| Pharmacology |
Upregulates the expression of MHC I proteins, allowing for increased presentation of peptides derived from viral antigens. This enhances the activation of CD8+ T cells that are the precursors for cytotoxic T lymphocytes (CTLs) and makes the macrophage a better target for CTL-mediated killing. Interferon alpha also induce the synthesis of several key antiviral mediators, including 2'-5' oligoadenylate synthetase (2'-5' A synthetase) and protein kinase R. |
| Mechanism Of Action |
Not Available |
Ribavirin and Alfa Interferon (Intron A) News
(When available) |
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| Dosage Forms |
CAPSULE;POWDER FOR SOLUTION |
| Drug_Category |
Coagulants; Thrombotic Agents; interferons (08:18.20);nucleosides and nucleotides (08:18.32) |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Not Available |
| Chemical Formula |
C860H1353N229O255S9 |
| Molecular Weight |
19269.1 |
| Smiles String |
Not Available |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Not Available |
| LogP/Hphobicity |
-0.339 |
| Isoelectric Point |
5.99 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
RXlist |
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| Drug Reference |
http://www.rxlist.com/cgi/generic2/ribav.htm |
| Drug Type |
Approved Drug |
| Accession No |
BIOD00015 |
| CAS Registry Number |
Not Available |
| KEGG Compound ID |
Not Available |
| PubChem ID |
Not Available |
| PharmGKB ID |
Not Available |
| SwissProt ID |
IFNA2_HUMAN (P01563) |
| GenBank ID |
J00207 |
| Drug ID Number [DIN] |
2246028
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