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Reserpine
drug data and news
Reserpine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Reserpine
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| Brand Names/Synonyms |
Serpalan (TN); Reserpine (JP14/USP); Cam-Ap-Es; Chlorothiazide And Reserpine; Chlorothiazide W/ Reserpine; Chlorothiazide-Reserpine; Demi-Regroton; Diupres-250; Diupres-500; Diutensen-R; Dralserp; H.R.-50; Hiserpia; Hydralazine Hcl, Hydrochlorothiazide And Reserpine; Hydralazine Hcl-Hydrochlorothiazide-Reserpine; Hydralazine, Hydrochlorothiazide W/ Reserpine; Hydrap-Es; Hydro-Reserp; Hydro-Serp "25"; Hydro-Serp "50"; Hydrochlorothiazide W/ Reserpine; Hydrochlorothiazide W/ Reserpine And Hydralazine; Hydroflumethiazide And Reserpine; Hydromox R; Hydropres 25; Hydropres 50; Hydroserpine Plus (R-H-H); Metatensin #2; Metatensin #4; Naquival; Novoreserpine; Rau-Sed; Regroton; Renese-R; Reserfia; Reserpine; Reserpine And Hydrochlorothiazide; Reserpine And Hydrochlorothiazide-50; Reserpine And Hydroflumethiazide; Reserpine, Hydralazine Hcl And Hydrochlorothiazide; Reserpine, Hydrochlorothiazide, And Hydralazine Hcl; Salutensin; Salutensin-Demi; Sandril; Ser-A-Gen; Ser-Ap-Es; Serpalan; Serpanray; Serpasil; Serpasil-Apresoline; Serpasil-Esidrix #1; Serpasil-Esidrix #2; Serpate; Serpivite; Trichlormethiazide W/ Reserpine; Unipres |
| Indication |
Foe the treatment of hypertension |
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Description |
Not Available |
| Pharmacology |
Reserpine is an adrenergic blocking agent used to treat mild to moderate hypertension via the disruption of norepinephrine vesicular storage. The antihypertensive actions of Reserpine are a result of its ability to deplete catecholamines from peripheral sympathetic nerve endings. These substances are normally involved in controlling heart rate, force of cardiac contraction and peripheral resistance. |
| Mechanism Of Action |
Reserpine's mechanism of action is through inhibition of the ATP/Mg2+ pump responsible for the sequestering of neurotransmitters into storage vesicles located in the presynaptic neuron. The neurotransmitters that are not sequestered in the storage vesicle are readily metabolized by monoamine oxidase (MAO) causing a reduction in catecholamines. |
Reserpine News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Antipsychotics; Antihypertensive Agents; Peripheral Adrenergic Inhibitors; ATC:C02AA02 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Possible human carcinogen. May cause reproductive harm. ORL-RAT LD50 420 mg kg-1; IPR-RAT LD50 44 mg kg-1; IVN-RAT LD50 15 mg kg-1; ORL-MUS LD50 200 mg kg-1; SCU-MUS LD50 52 mg kg-1; IPR-RBT LD50 7 mg kg-1 |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
Not Available |
| Chemical Formula |
C33H40N2O9 |
| Molecular Weight |
608.679 g/mol |
| Smiles String |
COC1C(CC2CN3CCC4=C(C3CC2C1C(=O)OC)NC5=C4C=CC(=C5)OC)OC(=O)C6=CC(=C(C(=C6)OC)OC)OC |
| Melting Point |
264.5 °C |
| Water Solubility |
73 mg/L |
| State |
Solid |
| LogP/Hphobicity |
3.32 |
| Isoelectric Point |
6.6 |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
62% |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Reserpine.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00472 |
| CAS Registry Number |
50-55-5 |
| KEGG Compound ID |
C06539 |
| PubChem ID |
SID:8769 |
| PharmGKB ID |
PA451236 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
21784
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