Ranitidine drug data and news

Ranitidine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Ranitidine
Brand Names/Synonyms Achedos; Acidex; Atural; Axoban; Coralen; Curan; Duractin; Ezopta; Gastrial; Gastrosedol; HSDB 3925; Istomar; Logast; Mauran; Melfax; Microtid; Noctone; Ptinolin; Quantor; Quicran; RND; Radinat; Randin; Raniben; Ranidine; Ranin; Raniogas; Raniplex; Ranisen; Raniter; Ranitidina [Inn-Spanish]; Ranitidine; Ranitidine Base; Ranitidine Hcl; Ranitidine Hydrochloride; Ranitidine [Usan:Ban:Inn]; Ranitidinum [Inn-Latin]; Ranitiget; Rantacid; Rantidine; Rantidine Hcl; Ratic; Raticina; Sampep; Sostril; Taural; Terposen; Trigger; Tritec; Ul-Pep; Ulceranin; Ulcex; Ultidine; Urantac; Verlost; Vesyca; Vizerul; Weichilin; Weidos; Xanidine; ZANTAC; Zantab; Zantac; Zantac 150; Zantac 75; Zantac in Plastic Container; Zantadin; Zantic; [Inn-Latin]
Indication For the treatment of peptic or duodenal ulcers
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Description Not Available
Pharmacology Ranitidine, a histamine H2-receptor antagonist similar to cimetidine and famotidine, is used to treat gastrointestinal disorders such as Helicobacter pylori-related peptic ulcer disease.
Mechanism Of Action Ranitidine competes with histamine for binding at H2 receptors on gastric parietal cells. Competitive inhibition results in reduced basal and nocturnal gastric acid secretion. Ranitidine also decreases the amount of gastric acid released in response to stimuli such as food, caffeine, insulin, betazole, or pentagastrin. Other actions of ranitidine include an increase in gastric bacterial flora such as nitrate-reducing organisms.
Ranitidine News
(When available)

Omnicare Adjusts Q1 Profit To Include Special Charge - Update  May 10, 2006
The inquiries relate to the substitution of capsules for tablets (Ranitidine), tablets for capsules (Fluoxetine) and two 7.5 mg tablets for one 15 mg tablet ... - Trading Markets,

Omnicare Files 2006 First Quarter 10-Q; Updates First Quarter ...  May 10, 2006
As previously disclosed, the inquiriesrelate to the substitution of capsules for tablets (Ranitidine),tablets for capsules (Fluoxetine) and two 7.5 mg tablets ... - Finanzen.net,

Omnicare allocates litigation funds  May 11, 2006
In a filing with the Securities and Exchange Commission, Omnicare said that the company had been accused of substituting capsules of Ranitidine for tablets of ... - Cincinnati Post,

Wockhardt to expand India operations  May 1, 2006
...these areas. In US, the company received US FDA approval for Ranitidine 75 mg, the OTC version of the anti-ulcer drug. Four new ... - News Today,

Omnicare takes $24M charge  May 11, 2006
...state and government representatives. The investigations involve the drugs ranitidine, fluoxetine and buspirone. The set-aside lowered ... - Cincinnati Enquirer,

Clinical: Tiredness, aspirin and PPIs  May 10, 2006
Can aspirin be prescribed with a PPI or ranitidine in patients who have been taking clopidogrel for one year after a coronary stent has been fitted and who ... - Therapeutics Daily (subscription) (press release),

Off-Label Drug Use  May 2, 2006
That drug as well as cimetidine (Tagamet), ranitidine (Zantac), famotidine (Pepcid), and sucralfate (Cara-fate) were (and in the case of all but Gastro-Gard ... - TheHorse.com,

NSAIDs: Pain Relief or Pain in the Gut?  May 2, 2006
Anti-ulcer medication (eg omeprazole, ranitidine, cimetidine) can be used in horses which have to be on NSAIDs long term due to musculoskeletal problems. ... - TheHorse.com,

SCS Capital to help fund Nanopharm project  Apr 30, 2006
Other newly developed drugs which Nanopharm will offer are betamecyl (eye-ointment), tegafur for cancer treatment, gammasulfam, ranitidine and azidothymidine ... - Business Times - Malaysia,

Wockhardt Q1 net loss at Rs 3.7 cr  Apr 25, 2006
...the year. In the US, the company has already received approval for Ranitidine 75 mg, the OTC version of the anti-ulcer drug. Four ... - Business Standard,

State sues over high prescription drug prices  Apr 28, 2006
The suit alleges, for example, that Par Pharmaceutical's ulcer medication Ranitidine was available for $27.70, but the company's average wholesale price that ... - Honolulu Advertiser,

Indigestion defined  Apr 29, 2006
The technical description for a medicine that blocks receptors in this way is “antagonist�. Examples are famotidine, cimetidine, nizatidine and ranitidine. ... - Malaysia Star,

Wockhardt reports net loss of Rs37mn  Apr 26, 2006
...during the year. In US, the company received USFDA approval for Ranitidine 75 mg, the OTC version of the anti-ulcer drug. Four new ... - India Infoline.com,

Dosage Forms CAPSULE; LIQUID; SOLUTION; TABLET
Drug_Category Anti-ulcer Agents; Histamine Antagonists; ATC:A02BA02; ATC:A02BA07
Absorption 50% absorbed after oral administration
Interactions Interactions for Ranitidine:

Coadministration of TRITEC with clarithromycin resulted in increased plasma ranitidine concentrations (57%), increased plasma bismuth trough concentrations (48%), and increased 14- hydroxy- clarithromycin plasma concentrations (31%). Coadministration with aspirin results in a slight decrease in the rate of salicylate absorption that is clinically unimportant. Coadministration with a high dose of antacid (170 mEq) results in a 28% decrease in plasma concentrations of ranitidine and may decrease plasma concentrations of bismuth from TRITEC. These effects are clinically insignificant.

For information on drug interactions associated with ranitidine, refer to the ZANTAC ® package insert.

Toxicity muscular tremors, vomiting, and rapid respiration, LD50=77mg/kg (orally in mice)
Organisms Affected Humans and other mammals
Chemical IUPAC Name N'-[2-[[5-(dimethylaminomethyl)-2-furyl]methylsulfanyl]ethyl]-N-methyl-2-nitro-ethene-1,1-diamine
Chemical Formula C13H22N4O3S
Molecular Weight 314.405 g/mol
Smiles String CNC(=C[N+](=O)[O-])NCCSCC1=CC=C(O1)CN(C)C
Melting Point 69-70 °C
Water Solubility 24.7 mg/mL
State Solid, a white to pale yellow, granular substance
LogP/Hphobicity 1.93
Isoelectric Point Not Available
Biotransformation Primarily Hepatic, Ranitidine is metabolized to the N-oxide, S-oxide, and N-desmethyl metabolites
Half Life 2.8-3.1 hours
Protein Binding [%] 15%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Ranitidine.html
http://www.rxlist.com/cgi/generic2/ranitbc.htm
http://www.pharmgkb.org/views/index.jsp?objId=
Drug Type Approved Drug
Accession No APRD00254
CAS Registry Number 66357-35-5
KEGG Compound ID C07233
PubChem ID SID:187111
PharmGKB ID PA451224
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2243038

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