Raloxifene drug data and news

Raloxifene drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Raloxifene
Brand Names/Synonyms CCRIS 7129; CHEMBANK1694; Evista; Keoxifene; RAL; Raloxifene; Raloxifene Hcl; Raloxifene Hydrochloride; Raloxifeno [Spanish]; Raloxifenum [Latin]
Indication For the prevention of osteoporosis in post-menopausal women
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Description Not Available
Pharmacology Raloxifene, a selective estrogen receptor modulator (SERM) of the benzothiophene class, is similar to tamoxifen in that it produces estrogen-like effects on bone and lipid metabolism, while antagonizing the effects of estrogen on mammary tissue. Raloxifene decreases bone resorption, increases bone mineral density (BMD) and decreases incidence of fractures. Raloxifene is used in the prevention of postmenopausal osteoporosis and breast cancer.
Mechanism Of Action Raloxifene binds to estrogen receptors, resulting in differential expression of multiple estrogen-regulated genes in different tissues. Raloxifene produces estrogen-like effects on bone, reducing resorption of bone and increasing bone mineral density in postmenopausal women. Raloxifene also antagonizes the effects of estrogen on mammary tissue and blocks uterotrophic responses to estrogen.
Raloxifene News
(When available)

New York Times Reporter Examines Recent Study Comparing Raloxifene ...  May 10, 2006
Denise Grady on Tuesday examined the recently announced initial results from a National Cancer Institute-sponsored study showing that the drug raloxifene is as ... - Kaiser network.org,

Benefits of Bone Thinning Drug Raloxifene as Breast Cancer ...  May 2, 2006
Preliminary results from the latest study on the bone thinning drug raloxifene have deemed it as a "preventive strike" against breast cancer, but the study ... - Kaiser network.org,

Study: Raloxifene prevents breast cancer as well as old standby ...  Apr 17, 2006
At least 2 million women might benefit from raloxifene's cancer-reducing effects, researchers said Monday in announcing initial results of the $88 million ... - OhmyNews International,

Raloxifene Reduces Breast Cancer Risk As Well As Tamoxifen  Apr 17, 2006
A study called STAR, Study of Tamoxifen and Raloxifene has shown, according to initial results, that Raloxifene is as effective as Tomoxifen in the prevention ... - Medical News Today,

Questions and Answers: Raloxifene better breast cancer fighter  Apr 17, 2006
Raloxifene or Evista, an osteoporosis drug, shows the same efficacy in invasive breast cancer prevention as tamoxifen , but without as much of adverse effects ... - Food Consumer,

STAR Study: Raloxifene is as effective as Tamoxifen in reducing ...  Apr 20, 2006
By NSABP, The Study of Tamoxifen and Raloxifene, or STAR, is a clinical trial designed see how the drug raloxifene compares with the drug tamoxifen in reducing ... - RxPG NEWS,

Osteoporosis Drug Raloxifene Shown to Be as Effective as Tamoxifen ...  Apr 17, 2006
BETHESDA, MD -- April 17, 2006 -- Initial results of the Study of Tamoxifen and Raloxifene, or STAR, show that the drug raloxifene, currently used to prevent ... - DG News

Osteoporosis drug Raloxifene shown to be as effective as Tamoxifen ...  Apr 17, 2006
Initial results of the Study of Tamoxifen and Raloxifene, or STAR, show that the drug raloxifene, currently used to prevent and treat osteoporosis in ... - News-Medical.net,

Success of Raloxifene to Prevent Breast Cancer is Encouraging for ...  Apr 19, 2006
April 19, 2006 – The study released Monday showing the drug raloxifene, currently used to prevent and treat osteoporosis in postmenopausal women, works as ... - SeniorJournal.com,

Raloxifene trumps tamoxifen in safety trials for breast cancer  Apr 18, 2006
Initial results of a clinical trial suggest that the osteoporosis drug raloxifene (trade name Evista) is as effective as tamoxifen (trade name Nolvadex) in ... - Food Consumer,

Raloxifene or tamoxifen: Which is the right drug for you?  Apr 19, 2006
Researchers on Monday reported that the osteoporosis drug raloxifene, marketed as Evista, is safer than tamoxifen and just as effective in reducing the risk of ... - AZ Central.com,

Raloxifene as Good as Tamoxifen to Prevent Breast Cancer  Apr 17, 2006
The bone drug raloxifene (Evista) is just as good as tamoxifen in preventing invasive breast cancer in high-risk women, federal health officials announced today ... - ACS News Center,

Allentonian Says Raloxifene is Helping Her Fight Breast Cancer  Apr 25, 2006
25--An Allentown woman who took part in a national study of two breast cancer prevention medicines credits the osteoporosis medicine raloxifene with helping ... - International News Service,

Study finds raloxifene may prevent breast cancer  Apr 19, 2006
Initial results of the national study released this week show that the osteoporosis drug raloxifene is as effective at preventing invasive breast cancer in ... - Buffalo News,

Raloxifene as effective as Tamoxifen in preventing invasive breast ...  Apr 18, 2006
Preliminary results of the STAR ( Study of Tamoxifen and Raloxifene ) trial showed that the drug Raloxifene ( Evista ), currently used to prevent and treat ... - Xagena.it,

Raloxifene: Less risky breast cancer prevention  Apr 18, 2006
The osteoporosis drug raloxifene is as effective as tamoxifen in reducing breast cancer risk among postmenopausal women at increased risk of the disease ... - MayoClinic.com

Comment: Should Women Switch From Tamoxifen to Raloxifene (Evista) ...  Apr 18, 2006
...which decided to preempt the planned summer release date for its study of two breast cancer drugs with a press release that extols the virtues of Raloxifene. ... - Food Consumer,

Raloxifene prevents breast cancer  Apr 18, 2006
Preliminary results from the Study of Tamoxifen and Raloxifene (STAR) clinical trial show that the drug raloxifene (brand name Evista) reduces postmenopausal ... - myDNA.com,

Raloxifene Better Than Tamoxifen For Breast Cancer  Apr 18, 2006
But the results of a 19,000-woman trial show that Eli Lilly and Co's Evista, known generically as raloxifene has fewer side effects. ... - MedIndia,

Raloxifene: Breakthrough or breakdown?  Apr 23, 2006
...good-news bulletin — “Breakthrough in Breast Cancer� — about a study of nearly 20,000 women testing one of two drugs, tamoxifen and raloxifene, for the ... - Quad City Times,

Raloxifene Acts Against Prostate Cancer  Apr 27, 2006
NEW YORK APR 26, 2006 (Reuters Health) - The selective estrogen-receptor modulator raloxifene appears to slow the progression of androgen-independent prostate ... - Cancerpage.com,

Study: Raloxifene prevents breast cancer as well as old standby ...  Apr 17, 2006
Called raloxifene, the newer drug already is sold to treat bone-thinning osteoporosis. But the striking new results, from a government ... - Penn Live,

Tamoxifen vs. Raloxifene  Apr 19, 2006
He says, "The study showed that this drug Raloxifene, which is a drug used to prevent osteoporosis, can reduce the risk of breast cancer equal as Tamixifen in ... - WTAP-TV,

Eli Lilly's Statement on Raloxifene  Apr 17, 2006
...released preliminary results of a breast cancer prevention study, looking at whether Eli Lilly & Co.'s Evista, known generically as raloxifene, approved in ... - Wall Street Journal (subscription),

Bone Thinning Drug Raloxifene As Effective As Tamoxifen In ...  Apr 20, 2006
The bone thinning drug raloxifene is as effective as the breast cancer prevention drug tamoxifen in reducing breast cancer risk for postmenopausal women ... - Medical News Today (press release),

Sorting Out Pills to Reduce Breast Cancer Risk  May 10, 2006
Now a major study has found that another drug, raloxifene, also lowers risk, with fewer side effects. The National Cancer Institute ... - New York Times,

Osteoporosis drug raloxifene shown to be as effective as tamoxifen ...  Apr 18, 2006
Initial results of the Study of Tamoxifen and Raloxifene (STAR) released: Osteoporosis drug raloxifene shown to be as effective as tamoxifen in preventing ... - PressZoom (press release),

Raloxifene Shows Advantages Over Tamoxifen in Breast Cancer ...  Apr 18, 2006
NEW YORK (Reuters Health) Apr 17 - Initial results from the Study of Tamoxifen and Raloxifene (STAR) trial show that the anti-osteoporosis drug raloxifene ... - Medscape (subscription)

Huntington Hospital Specialist Will Explain New Raloxifene ...  Apr 18, 2006
Hospital's Steven Applebaum, MD, a medical oncologist who has enrolled patients in the STAR Clinical Trial (Study of Tamoxifen and Raloxifene), is available to ... - PR Newswire (press release),

Osteoporosis drug holds hope in breast cancer fight  May 15, 2006
Moseley was one of 388 Wisconsin women who participated in the study that last month found the osteoporosis treatment drug raloxifene worked just as well as ... - Milwaukee Journal Sentinel (subscription),

Is new breast cancer pill better?  May 11, 2006
A second drug, raloxifene, left, was announced to be just as good as tamoxifen at preventing breast cancer -- with fewer side effects. See full image. ... - DetNews.com,

Lilly Calls Tamoxifen/Raloxifene Study Important Milestone  Apr 17, 2006
Eli Lilly & Co. (LLY) said results from Tamoxifen and Raloxifene trials conducted by researchers with the National Surgical Adjuvant Breast and Bowel Project ... - Therapeutics Daily (subscription) (press release),

Study: Raloxifene prevents breast cancer as well as old standby ...  Apr 17, 2006
Called raloxifene, the newer drug already is sold to treat bone-thinning osteoporosis. But the striking new results, from a government ... - The State,

Patients at Risk for Cancer Find Comfort, Hope in Study  May 9, 2006
...who is at risk for cancer – participated in the groundbreaking study of the breast cancer drug Tamoxifen® and the osteoporosis drug Raloxifene® by the ... - Newswise (press release)

Raloxifene Acts Against Prostate Cancer  Apr 27, 2006
NEW YORK (Reuters Health) - The selective estrogen-receptor modulator raloxifene appears to slow the progression of androgen-independent prostate cancer ... - UroToday,

Safer Drug Fights Cancer of the Breast  May 6, 2006
Raloxifene - sold under the brand name Evista - has proved just as effective, but significantly safer, at staving off breast cancer in high-risk women when ... - International News Service,

No Magic Pill, After All Drugs to Reduce Breast Cancer Risk Get ...  May 11, 2006
...the National Cancer Institute took another shot at prevention, when it held a news conference and jubilantly announced that a second drug, raloxifene, was just ... - International News Service,

... Go to the Article  May 5, 2006
The osteoporosis drug raloxifene works as well as tamoxifen in reducing invasive breast cancer risk – with fewer side effects – for high-risk ... - CancerWise

Eli Lilly gets better breast cancer drug  Apr 17, 2006
The Study of Tamoxifen and Raloxifene (STAR) is a clinical trial designed to see how the drug raloxifene (Evista®) compares with the drug tamoxifen (Nolvadex ... - Food Consumer,

BRMC completes breast cancer trial  May 12, 2006
STAR, the Study of Tamoxifen And Raloxifene, compared the effectiveness of two drugs in preventing breast cancer: Tamoxifen and Raloxifene. ... - Times-Mail (subscription),

Women needlessly having breast cancer surgery: doctor  May 15, 2006
MONICA MORROW: That's a drug which is called Raloxifene, which, although it's not a treatment for established breast cancer, has just recently been shown in ... - ABC Online,

News from Vanderbilt University  Apr 17, 2006
NASHVILLE, Tenn. – Initial Results of the Study of Tamoxifen and Raloxifene or STAR, released today revealed the osteoporosis drug raloxifene has been proved ... - Vanderbilt University News,

Too Early to Declare Victory In the War Against Breast Cancer  May 1, 2006
Rah! Rah! Raloxifene! ... Raloxifene is being hailed as a preemptive strike against breast cancer, a new weapon to stop insurgent cells before they get started. ... - Washington Post,

Troubled teeth affect more than your mouth  May 14, 2006
Study completed: In April, initial results of the National Cancer Institute's Study of Tamoxifen and Raloxifene (STAR) found the drug raloxifene worked as well ... - York Daily Record,

Your Health This Month  May 2, 2006
Tamoxifen and raloxifene: There is good news in another large study that's soon to be formally reported. The National Cancer Institute's ... - Slate

Cancer-study news ‘exciting’  May 2, 2006
CANTON The results of a recent study indicating that the newer drug raloxifene was as effective in fighting breast cancer in older women as tamoxifen — with ... - Canton Repository (subscription),

New breast cancer treatment claims few side effects  Apr 18, 2006
20,000 women in Canada, the United States and Puerto Rico — one of the largest of its kind — has found that the osteoporosis drug raloxifene also helps ... - Toronto Star,

Breast cancer drug is 'big deal'  Apr 20, 2006
But like so many medicines on the market, the drug — raloxifene — might not be for everyone. The National Cancer Institute announced ... - Rochester Democrat and Chronicle,

Bone Drug Cuts Risk of Breast Cancer: Study: Osteoporosis Medicine ...  Apr 17, 2006
18--The bone-strengthening drug raloxifene can prevent invasive breast cancer just as well as better-known tamoxifen, with fewer serious side effects, one of ... - International News Service,

New Cancer Drug Shows Fewer Side Effects  Apr 24, 2006
...(Stock photo / Molly Courtright ) :: At least 2 million women might benefit from raloxifene's cancer-reducing effects, researchers said Monday in announcing ... - HappyNews.com,

Dosage Forms Tablet
Drug_Category Antihypocalcemic Agents; Osteoporosis Prophylactic; Selective Estrogen Receptor Modulators; Estrogen Antagonists; ATC:G03XC01
Absorption Approximately 60% of an oral dose is absorbed, but presystemic glucuronide conjugation is extensive. Absolute bioavailability of raloxifene is 2.0%
Interactions Interactions for Raloxifene:

Cholestyramine: Cholestyramine causes a 60% reduction in the absorption and enterohepatic cycling of raloxifene and should not be coadministered with EVISTA.

Warfarin: The coadministration of EVISTA and warfarin has not been assessed under chronic conditions. However, 10% decreases in prothrombin time have been observed in single-dose studies. If EVISTA is given concurrently with warfarin, prothrombin time should be monitored.

Other Highly Protein-Bound Drugs: Raloxifene is more than 95% bound to plasma proteins. In vitro, raloxifene did not affect the binding of warfarin, phenytoin, or tamoxifen. Caution should be used when EVISTA is coadministered with other highly protein-bound drugs, such as clofibrate, indomethacin, naproxen, ibuprofen, diazepam, and diazoxide.

See also CLINICAL PHARMACOLOGY, Drug-Drug Interactions

Toxicity Not Available
Organisms Affected Humans and other mammals
Chemical IUPAC Name [6-hydroxy-2-(4-hydroxyphenyl)-benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]-methanone
Chemical Formula C28H27NO4S
Molecular Weight 473.584 g/mol
Smiles String C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O
Melting Point 143-147°C
Water Solubility 0.25mg/L
State off-white to pale-yellow solid
LogP/Hphobicity 5.749
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 27.7
Protein Binding [%] 95%
RxList Link RXlist
Sponsored links
Drug Reference http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/evi1169.shtml
http://www.drugs.com/cons/Raloxifene.html
http://www.rxlist.com/cgi/generic/raloxif.htm
Drug Type Approved Drug
Accession No APRD00400
CAS Registry Number 84449-90-1
KEGG Compound ID C07228
PubChem ID SID:148636
PharmGKB ID PA451221
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 2239028

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