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Raloxifene
drug data and news
Raloxifene drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Raloxifene | ||
| Brand Names/Synonyms | CCRIS 7129; CHEMBANK1694; Evista; Keoxifene; RAL; Raloxifene; Raloxifene Hcl; Raloxifene Hydrochloride; Raloxifeno [Spanish]; Raloxifenum [Latin] | ||
| Indication | For the prevention of osteoporosis in post-menopausal women | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Raloxifene, a selective estrogen receptor modulator (SERM) of the benzothiophene class, is similar to tamoxifen in that it produces estrogen-like effects on bone and lipid metabolism, while antagonizing the effects of estrogen on mammary tissue. Raloxifene decreases bone resorption, increases bone mineral density (BMD) and decreases incidence of fractures. Raloxifene is used in the prevention of postmenopausal osteoporosis and breast cancer. | ||
| Mechanism Of Action | Raloxifene binds to estrogen receptors, resulting in differential expression of multiple estrogen-regulated genes in different tissues. Raloxifene produces estrogen-like effects on bone, reducing resorption of bone and increasing bone mineral density in postmenopausal women. Raloxifene also antagonizes the effects of estrogen on mammary tissue and blocks uterotrophic responses to estrogen. | ||
| Raloxifene News (When available) |
New York Times Reporter Examines Recent Study Comparing Raloxifene ... May 10, 2006 Benefits of Bone Thinning Drug Raloxifene as Breast Cancer ... May 2, 2006 Study: Raloxifene prevents breast cancer as well as old standby ... Apr 17, 2006 Raloxifene Reduces Breast Cancer Risk As Well As Tamoxifen Apr 17, 2006 Questions and Answers: Raloxifene better breast cancer fighter Apr 17, 2006 STAR Study: Raloxifene is as effective as Tamoxifen in reducing ... Apr 20, 2006 Osteoporosis Drug Raloxifene Shown to Be as Effective as Tamoxifen ... Apr 17, 2006 Osteoporosis drug Raloxifene shown to be as effective as Tamoxifen ... Apr 17, 2006 Success of Raloxifene to Prevent Breast Cancer is Encouraging for ... Apr 19, 2006 Raloxifene trumps tamoxifen in safety trials for breast cancer Apr 18, 2006 Raloxifene or tamoxifen: Which is the right drug for you? Apr 19, 2006 Raloxifene as Good as Tamoxifen to Prevent Breast Cancer Apr 17, 2006 Allentonian Says Raloxifene is Helping Her Fight Breast Cancer Apr 25, 2006 Study finds raloxifene may prevent breast cancer Apr 19, 2006 Raloxifene as effective as Tamoxifen in preventing invasive breast ... Apr 18, 2006 Raloxifene: Less risky breast cancer prevention Apr 18, 2006 Comment: Should Women Switch From Tamoxifen to Raloxifene (Evista) ... Apr 18, 2006 Raloxifene prevents breast cancer Apr 18, 2006 Raloxifene Better Than Tamoxifen For Breast Cancer Apr 18, 2006 Raloxifene: Breakthrough or breakdown? Apr 23, 2006 Raloxifene Acts Against Prostate Cancer Apr 27, 2006 Study: Raloxifene prevents breast cancer as well as old standby ... Apr 17, 2006 Tamoxifen vs. Raloxifene Apr 19, 2006 Eli Lilly's Statement on Raloxifene Apr 17, 2006 Bone Thinning Drug Raloxifene As Effective As Tamoxifen In ... Apr 20, 2006 Sorting Out Pills to Reduce Breast Cancer Risk May 10, 2006 Osteoporosis drug raloxifene shown to be as effective as tamoxifen ... Apr 18, 2006 Raloxifene Shows Advantages Over Tamoxifen in Breast Cancer ... Apr 18, 2006 Huntington Hospital Specialist Will Explain New Raloxifene ... Apr 18, 2006 Osteoporosis drug holds hope in breast cancer fight May 15, 2006 Is new breast cancer pill better? May 11, 2006 Lilly Calls Tamoxifen/Raloxifene Study Important Milestone Apr 17, 2006 Study: Raloxifene prevents breast cancer as well as old standby ... Apr 17, 2006 Patients at Risk for Cancer Find Comfort, Hope in Study May 9, 2006 Raloxifene Acts Against Prostate Cancer Apr 27, 2006 Safer Drug Fights Cancer of the Breast May 6, 2006 No Magic Pill, After All Drugs to Reduce Breast Cancer Risk Get ... May 11, 2006 ... Go to the Article May 5, 2006 Eli Lilly gets better breast cancer drug Apr 17, 2006 BRMC completes breast cancer trial May 12, 2006 Women needlessly having breast cancer surgery: doctor May 15, 2006 News from Vanderbilt University Apr 17, 2006 Too Early to Declare Victory In the War Against Breast Cancer May 1, 2006 Troubled teeth affect more than your mouth May 14, 2006 Your Health This Month May 2, 2006 Cancer-study news ‘exciting’ May 2, 2006 New breast cancer treatment claims few side effects Apr 18, 2006 Breast cancer drug is 'big deal' Apr 20, 2006 Bone Drug Cuts Risk of Breast Cancer: Study: Osteoporosis Medicine ... Apr 17, 2006 New Cancer Drug Shows Fewer Side Effects Apr 24, 2006 | ||
| Dosage Forms | Tablet | ||
| Drug_Category | Antihypocalcemic Agents; Osteoporosis Prophylactic; Selective Estrogen Receptor Modulators; Estrogen Antagonists; ATC:G03XC01 | ||
| Absorption | Approximately 60% of an oral dose is absorbed, but presystemic glucuronide conjugation is extensive. Absolute bioavailability of raloxifene is 2.0% | ||
| Interactions |
Interactions for Raloxifene: Cholestyramine: Cholestyramine causes a 60% reduction in the absorption and enterohepatic cycling of raloxifene and should not be coadministered with EVISTA. Warfarin: The coadministration of EVISTA and warfarin has not been assessed under chronic conditions. However, 10% decreases in prothrombin time have been observed in single-dose studies. If EVISTA is given concurrently with warfarin, prothrombin time should be monitored. Other Highly Protein-Bound Drugs: Raloxifene is more than 95% bound to plasma proteins. In vitro, raloxifene did not affect the binding of warfarin, phenytoin, or tamoxifen. Caution should be used when EVISTA is coadministered with other highly protein-bound drugs, such as clofibrate, indomethacin, naproxen, ibuprofen, diazepam, and diazoxide. See also CLINICAL PHARMACOLOGY, Drug-Drug Interactions | ||
| Toxicity | Not Available | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | [6-hydroxy-2-(4-hydroxyphenyl)-benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]-methanone | ||
| Chemical Formula | C28H27NO4S | ||
| Molecular Weight | 473.584 g/mol | ||
| Smiles String | C1CCN(CC1)CCOC2=CC=C(C=C2)C(=O)C3=C(SC4=C3C=CC(=C4)O)C5=CC=C(C=C5)O | ||
| Melting Point | 143-147°C | ||
| Water Solubility | 0.25mg/L | ||
| State | off-white to pale-yellow solid | ||
| LogP/Hphobicity | 5.749 | ||
| Isoelectric Point | Not Available | ||
| Biotransformation | Hepatic | ||
| Half Life | 27.7 | ||
| Protein Binding [%] | 95% | ||
| RxList Link | RXlist | ||
| Sponsored links | |||
| Drug Reference |
http://www.pdrhealth.com/drug_info/rxdrugprofiles/drugs/evi1169.shtml http://www.drugs.com/cons/Raloxifene.html http://www.rxlist.com/cgi/generic/raloxif.htm | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00400 | ||
| CAS Registry Number | 84449-90-1 | ||
| KEGG Compound ID | C07228 | ||
| PubChem ID | SID:148636 | ||
| PharmGKB ID | PA451221 | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | 2239028 |
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