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Quinacrine
drug data and news
Quinacrine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
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| Generic name | Quinacrine | ||
| Brand Names/Synonyms | Acrichine; Acrinamine; Acriquine; Akrichin; Antimalarina; Atabrine; Atebrin; Atebrine; Erion; Erion Hydrochloride; Haffkinine; Italchine; Mepacrine; Quinacrine; Quinacrine Dihydrochloride; Quinactine | ||
| Indication | For the treatment of giardiasis and cutaneous leishmaniasis and the management of malignant effusions. | ||
| Sponsored links | Description | Not Available | |
| Pharmacology | Quinacrine has been used as an antimalarial drug and as an antibiotic. It is used to treat giardiasis, a protozoal infection of the intestinal tract, and certain types of lupus erythematosus, an inflammatory disease that affects the joints, tendons, and other connective tissues and organs. Quinacrine may be injected into the space surrounding the lungs to prevent reoccurrence of pneumothorax. The exact way in which quinacrine works is unknown. It appears to interfere with the parasite's metabolism. | ||
| Mechanism Of Action | The exact mechanism of antiparasitic action is unknown; however, quinacrine binds to deoxyribonucleic acid (DNA) in vitro by intercalation between adjacent base pairs, inhibiting transcription and translation to ribonucleic acid (RNA). Quinacrine does not appear to localize to the nucleus of Giaridia trophozoites, suggesting that DNA binding may not be the primary mechanism of its antimicrobial action. Fluorescence studies using Giardia suggest that the outer membranes may be involved. Quinacrine inhibits succinate oxidation and interferes with electron transport. In addition, by binding to nucleoproteins, quinacrine suppress the lupus erythematous cell factor and acts as a strong inhibitor of cholinesterase. | ||
| Quinacrine News (When available) |
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| Dosage Forms | TABLET | ||
| Drug_Category | Antineoplastic Agents; Antinematodal Agents; Antimalarials; Anticestodal Agents; Enzyme Inhibitors | ||
| Absorption | Absorbed rapidly from the gastrointestinal tract following oral administration. | ||
| Interactions |
Interactions for Quinacrine: Alcohol (this combination may make you very sick) and primaquine | ||
| Toxicity | Oral, rat: LD50 = 900 mg/kg; Oral, mouse: LD50 = 1000 mg/kg. Symptoms of overdose include seizures, hypotension, cardiac arrhythmias, and cardiovascular collapse. | ||
| Organisms Affected | Humans and other mammals | ||
| Chemical IUPAC Name | N'-(6-chloro-2-methoxy-acridin-9-yl)-N,N-diethyl-pentane-1,4-diamine | ||
| Chemical Formula | C23H30ClN3O | ||
| Molecular Weight | 399.957 g/mol | ||
| Smiles String | CCN(CC)CCCC(C)NC1=C2C=C(C=CC2=NC3=C1C=CC(=C3)Cl)OC | ||
| Melting Point | 248-250 °C | ||
| Water Solubility | Slight | ||
| State | Solid | ||
| LogP/Hphobicity | 5.388 | ||
| Isoelectric Point | 10.3 | ||
| Biotransformation | Not Available | ||
| Half Life | 5 to 14 days | ||
| Protein Binding [%] | 80-90% | ||
| RxList Link | Not Available>RXlist | ||
| Sponsored links | |||
| Drug Reference | http://www.drugs.com/cons/Quinacrine.html | ||
| Drug Type | Approved Drug | ||
| Accession No | APRD00317 | ||
| CAS Registry Number | 83-89-6 | ||
| KEGG Compound ID | C07339 | ||
| PubChem ID | SID:290493 | ||
| PharmGKB ID | Not Available | ||
| SwissProt ID | Not Available | ||
| GenBank ID | Not Available | ||
| Drug ID Number [DIN] | Not Available |
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