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Propylthiouracil
drug data and news
Propylthiouracil drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Propylthiouracil
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| Brand Names/Synonyms |
PTU; Procasil; Propacil; Propilthiouracil; Propycil; Propyl-Thiorist; Propyl-Thiorit; Propyl-Thyracil; Propylthiorit; Propylthiouracil; Propylthiouracil Ph Eur; Propythiouracil; Prothiucil; Prothiurone; Prothycil; Prothyran; Protiural; T 72; Thiuragyl; Thyreostat Ii |
| Indication |
Used to manage hyperthyroidism which is due to an overactive thyroid gland (Grave’s disease) |
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Description |
Not Available |
| Pharmacology |
Used in the treatment of hyperthyroidism or an overactive thyroid gland, Propylthiouracil inhibits the synthesis of thyroid hormones and thus is effective in the treatment of hyperthyroidism. It may also be used to ameliorate hyperthyroidism in preparation for subtotal thyroidectomy or radioactive iodine therapy. |
| Mechanism Of Action |
Propylthiouracil binds to thyroid peroxidase and thereby inhibits the conversion of iodide to iodine. Thyroid peroxidase normally converts iodide to iodine (via hydrogen peroxide as a cofactor) and also catalyzes the incorporation of the resulting iodide molecule onto both the 3 and/or 5 positions of the phenol rings of tyrosines found in thyroglobulin. Thyroglobulin is degraded to produce thyroxine (T4) and tri-iodothyronine (T3), which are the main hormones produced by the thyroid gland. So Propylthiouracil effectively inhibits the production of new thyroid hormones. |
Propylthiouracil News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Antithyroid Agents; Antimetabolites; ATC:H03BA02 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
LD50 = 1250 mg/kg (rat, oral) |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
6-propyl-2-sulfanyl-pyrimidin-4-ol |
| Chemical Formula |
C7H10N2OS |
| Molecular Weight |
170.233 g/mol |
| Smiles String |
CCCC1=CC(=NC(=N1)S)O |
| Melting Point |
219 °C |
| Water Solubility |
1200 mg/L |
| State |
Solid |
| LogP/Hphobicity |
2.055 |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
9.3 +/- 1.4 hrs |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Propylthiouracil.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00297 |
| CAS Registry Number |
51-52-5 |
| KEGG Compound ID |
C07569 |
| PubChem ID |
SID:9772 |
| PharmGKB ID |
PA451156 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
10219
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