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Propantheline
drug data and news
Propantheline drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.
| Generic name |
Propantheline
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| Brand Names/Synonyms |
CHEMBANK1397; HSDB 3174; Pro-Banthine; Propanthel; Propantheline; Propantheline Bromide; Propanthelinium; Propanthelinum |
| Indication |
For the treatment of enuresis |
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Description |
Not Available |
| Pharmacology |
Propantheline is an anticholinergic drug, a medication that reduces the effect of acetylcholine, a chemical released from nerves that stimulates muscles, by blocking the receptors for acetylcholine on smooth muscle (a type of muscle). It also has a direct relaxing effect on smooth muscle. Propantheline is used to treat or prevent spasm in the muscles of the gastrointestinal tract in the irritable bowel syndrome. In addition, Propantheline inhibits gastrointestinal propulsive motility and decreases gastric acid secretion and controls excessive pharyngeal, tracheal and bronchial secretions. |
| Mechanism Of Action |
Action is achieved via a dual mechanism: (1) a specific anticholinergic effect (antimuscarinic) at the acetylcholine-receptor sites and (2) a direct effect upon smooth muscle (musculotropic). |
Propantheline News
(When available) |
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| Dosage Forms |
TABLET |
| Drug_Category |
Anti-ulcer Agents; Antimuscarinics; Antispasmodics; ATC:A03AB05 |
| Absorption |
Not Available |
| Interactions |
Not Available |
| Toxicity |
Not Available |
| Organisms Affected |
Humans and other mammals |
| Chemical IUPAC Name |
methyl-bis(1-methylethyl)-[2-(9H-xanthen-9-ylcarbonyloxy)ethyl]ammonium |
| Chemical Formula |
C23H30NO3 |
| Molecular Weight |
368.489 g/mol |
| Smiles String |
CC(C)[N+](C)(CCOC(=O)C1C2=CC=CC=C2OC3=CC=CC=C13)C(C)C |
| Melting Point |
Not Available |
| Water Solubility |
Not Available |
| State |
Solid |
| LogP/Hphobicity |
Not Available |
| Isoelectric Point |
Not Available |
| Biotransformation |
Not Available |
| Half Life |
Not Available |
| Protein Binding [%] |
Not Available |
| RxList Link |
Not Available>RXlist |
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| Drug Reference |
http://www.drugs.com/cons/Propantheline.html |
| Drug Type |
Approved Drug |
| Accession No |
APRD00177 |
| CAS Registry Number |
298-50-0 |
| KEGG Compound ID |
C07506 |
| PubChem ID |
SID:9709 |
| PharmGKB ID |
PA451133 |
| SwissProt ID |
Not Available |
| GenBank ID |
Not Available |
| Drug ID Number [DIN] |
2030837
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