Promethazine drug data and news

Promethazine drug data, resources, and news articles (when available). Onconews.org provides news on cancer research. This section, which includes profiles on medicines that may or not be cancer-related is in beta form. If things run smoothly we will be releasing a new format late in the summer of 2006.

Generic name Promethazine
Brand Names/Synonyms 3277 RP; 3389 R.P.; 4182 R.P.; Allergan; Aprobit; Atosil; Avomine; Dimapp; Diphergan; Diprazine; Diprozin; Dorme; Duplamin; Fargan; Fellozine; Fenazil; Fenergan; Fenetazina; Genphen; Hiberna; Histargan; Iergigan; Isophenergan; Isopromethazine; Lercigan; Lergigan; Lilly 1516; Mymethazine Fortis; PHENERGAN/COD; Phargan; Phenargan; Phencen; Phenergan; Phenergan Fortis; Phensedyl; Pilpophen; Pipolphen; Proazaimine; Proazamine; Procit; Promazinamide; Prometasin; Prometazin; Prometh Fortis; Prometh Plain; Promethacon; Promethaine; Promethazin; Promethazine; Promethazine Hcl; Promethazine Plain; Promethegan; Promethiazine; Promezathine; Prorex; Protazine; Prothazin; Prothazine; Provigan; Pyrethia; Pyrethiazine; RP 3277; RP-3277; Remsed; Romergan; SKF 1498; Synalgos; Tanidil; Thiergan; Valergine; Vallergine; WY 509; Zipan-25
Indication For the treatment of allergic disorders, itching, nausea and vomiting
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Description Not Available
Pharmacology Promethazine, a phenothiazine, is an H1-antagonist with anticholinergic, sedative, and antiemetic effects and some local anesthetic properties. Promethazine is used as an antiemetic or to prevent motion sickness.
Mechanism Of Action Like other H1-antagonists, promethazine competes with free histamine for binding at H1-receptor sites in the GI tract, uterus, large blood vessels, and bronchial muscle. The relief of nausea appears to be related to central anticholinergic actions and may implicate activity on the medullary chemoreceptor trigger zone.
Promethazine News
(When available)

Akathisia With Combined Use of Midodrine and Promethazine  May 2, 2006
1 Promethazine is the antiemetic of choice by National Aeronautics and Space Administration (NASA) flight surgeons for the treatment of postflight nausea and ... - Journal of American Medical Association (subscription),

Antihistamine promethazine: Warning for kids under 2  Apr 27, 2006
Federal health officials are warning parents and doctors not to give medications containing the antihistamine promethazine, marketed as Phenergan, to children ... - MayoClinic.com

FDA Rules Out Promethazine HCl for Kids Under 2  Apr 26, 2006
WASHINGTON - Federal health officials warned parents and doctors Tuesday not to give drugs that contain promethazine hydrochloride to children younger than 2 ... - International News Service,

FDA issues label change for promethazine HCl  Apr 28, 2006
The Food and Drug Administration (FDA) has issued a label change stating that medications containing promethazine hydrochloride (HCl) should not be used for ... - AAP News (subscription)

Phenergan should be a controlled drug!  May 15, 2006
Has anyone ever had to take Phenergan, also known as Promethazine or Promethagan??? This drug should be Controlled just like vicodin or clonazepam..... ... - ProgressiveU.org,

IN THE NEWS  May 9, 2006
The US Food and Drug Administration is warning parents and physicians to stop giving the allergy drug promethazine HCl (also known as Phenergan) to children ... - Parents.com

FDA Warns of Antihistamine-Related Deaths in Young Children  Apr 26, 2006
Although the Food and Drug Administration FDA approved labeling for the antihistamine, promethazine, already contained a warning about the risk of serious ... - Newsinferno.com,

Allergy Drug Shouldn't Be Given to Young Children: FDA  Apr 26, 2006
Children younger than 2 years old should not be given the antihistamine promethazine hydrochloride, says a US Food and Drug Administration safety alert. ... - HealthCentral.com

Patrick Kennedy Crashes Car Into a Capitol Hill Barrier  May 5, 2006
A description of side effects of promethazine, the generic form of Phenergan, on Medicine.net, includes the statement: "Excessive sedation may occur when ... - New York Times,

In Brief: Autism  May 5, 2006
Federal officials are warning parents and doctors not to give drugs that contain promethazine hydrochloride to children younger than 2, citing seven cases of ... - Baltimore Sun,

Leon traffic stop nets 132 pints of codeine  Apr 29, 2006
A state trooper said he discovered about 132 pints of promethazine codeine - prescription cough syrup valued at $26,400 - on the floorboard of a truck during a ... - Bryan College Station Eagle,

Prescription cough syrup lands man in jail  Apr 17, 2006
Tests revealed the bottles contained Promethazine, a codeine-based narcotic cough medicine that has become increasingly popular at high schools. ... - Seguin Gazette-Enterprise,

More on the drugs Rep. Kennedy blames  May 5, 2006
According to MedicineNet on Phenergan, "Excessive sedation may occur when promethazine is combined with other medications that depress the central nervous ... - USA Today

FDA warns antihistamine linked to deaths in children under 2  Apr 26, 2006
WASHINGTON (AP) - US government health officials warned parents and doctors Tuesday not to give drugs that contain promethazine hydrochloride to children ... - Canada.com,

Patrick Kennedy's Psychedelic Freak Out!  May 5, 2006
He’s not the first to mix that particular cocktail: My wife is frequently prescribed phenergan (promethazine) for stomach problems. ... - Yahoo! News

Houston judge forbids physician to use doctor title  Apr 26, 2006
...the two drugs," Balboni said, referring to the painkiller hydrocodone, known by brand names such as Vicodin, and the cough syrup promethazine with codeine. ... - Houston Chronicle,

Athlete to stand trial in separate case  Apr 26, 2006
Federal health officials warned parents and doctors Tuesday not to give drugs that contain promethazine hydrochloride to children younger than 2, citing seven ... - Seattle Times,

Judge orders doctor never to use medical title again  Apr 26, 2006
...other doctors writing illegal prescriptions for the painkiller hydrocodone, known by such brand names as Vicodin, and the cough syrup promethazine with codeine ... - Houston Chronicle,

Medication Warning  Apr 25, 2006
The Food and Drug Administration is warning against giving antihistamine with the ingredient promethazine hydochrloride to children younger than two. ... - WOWT,

Probe points to ex-nurse at Shands in death of student  Apr 19, 2006
An examination showed Michelle Herndon had promethazine and four times the normal amount of propofol in her system, according to police and her family. ... - Gainesville Sun,

Julius Berger Imports Fake Drugs, Says NAFDAC  Apr 20, 2006
Others are 0.5 per cent metronidazole injection, diclofenate Sodium injection, Promethazine HCI injection, Aminophylline injection, Tetracycline eye ointment ... - Nigeria Daily Independent,

Seasick without the sea  May 4, 2006
Other medications CDC recommends are scopolamine, oral meclizine (Bonine, Antivert or another form of Dramamine), diphenhydramine (Benadryl) and promethazine. ... - The Casper Star Tribune,

Kids Getting High Sipping on Sizzurp  May 3, 2006
...a jolly rancher. The main ingredient in getting high? Promethazine or Dextromethorphan also known as DXM. "Cough syrup, DXM, if ... - WFSB,

This Week in Health  Apr 28, 2006
Young children under 2 years of age should not be given the antihistamine promethazine hydrochloride, because it carries a risk of serious side effects and ... - Intelihealth.com,

FDA: Don't give tots allergy drug  Apr 30, 2006
WASHINGTON -- Federal health officials warned parents and doctors this past week not to give drugs that contain promethazine hydrochloride to children younger ... - Indianapolis Star,

Kennedy crashes car into DC traffic barrier  May 4, 2006
According to the medical Web site WebMD.com, promethazine, the generic name for Phenergan, is used to prevent and treat nausea and vomiting related to certain ... - Providence Journal (subscription),

FDA Warns Antihistamine Linked to Deaths  Apr 25, 2006
WASHINGTON Apr 25, 2006 (AP)— Federal health officials warned parents and doctors Tuesday not to give drugs that contain promethazine hydrochloride to ... - ABC News

FDA warns against use of antihistamine for children under 2  Apr 25, 2006
The US Food and Drug Administration (FDA) on Tuesday warned against the use of allergy drug that contain promethazine hydrochloride (HCL) to children less than ... - People's Daily Online,

FDA warns against use of antihistamine for children under 2  Apr 25, 2006
April 25 (Xinhua) -- The US Food and Drug Administration (FDA) on Tuesday warned against the use of allergy drug that contain promethazine hydrochloride (HCL ... - Xinhua,

2,500 gallons of codeine syrup and a suicide  Apr 28, 2006
...the sentencing of a doctor whose "office workers produced prescriptions for 1.8 million tablets of hydrocodone and 2,500 gallons of promethazine with codeine ... - Houston Chronicle,

FDA Warns About Antihistamine  Apr 27, 2006
...years old. The Food and Drug Administration says seven deaths have been linked to promethazine hydrochloride in young children. The ... - WKRC 12,

FDA Issues Antihistamine Warning  Apr 25, 2006
The agency cites seven fatal cases linked to promethazine hydrochloride, sold by Wyeth under the brand name Phenergan as well as in various generic versions. ... - All Headline News

Judge strips doctor of title for writing fake prescriptions  Apr 27, 2006
...her office produced prescriptions for 1.8 million tablets of hydrocodone, known by brand names such as Vicodin, and 2,500 gallons of promethazine with codeine ... - Fort Worth Star Telegram,

Dosage Forms Tablets, suppositories, opthalmic drops, syrup
Drug_Category Anti-allergic Agents; Antipruritics; Phenothiazine Derivatives; ATC:D04AA10; ATC:R06AD02; ATC:R06AD05
Absorption On average, 88% of a promethazine dose is absorbed after oral administration; however, the absolute bioavailability is only 25% because of first-pass clearance
Interactions -->Interactions for Promethazine:

Injection:

Narcotics And Barbiturates: The CNS-depressant effects of narcotics are additive with promethazine hydrochloride.

Monoamine Oxidase Inhibitors (Maoi): Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. Although such a reaction has not been reported with promethazine, the possibility should be considered.


Syrup, Tablets and Suppositories:

CNS Depressants - Phenergan Tablets and Suppositories may increase, prolong, or intensify the sedative action of other central-nervous-system depressants, such as alcohol, sedatives/hypnotics (including barbiturates), narcotics, narcotic analgesics, general anesthetics, tricyclic antidepressants, and tranquilizers; therefore, such agents should be avoided or administered in reduced dosage to patients receiving promethazine HCl. When given concomitantly with Phenergan Tablets and Suppositories, the dose of barbiturates should be reduced by at least one-half, and the dose of narcotics should be reduced by one-quarter to one-half. Dosage must be individualized. Excessive amounts of promethazine HCl relative to a narcotic may lead to restlessness and motor hyperactivity in the patient with pain; these symptoms usually disappear with adequate control of the pain.

Epinephrine - Because of the potential for Phenergan to reverse epinephrineís vasopressor effect, epinephrine should NOT be used to treat hypotension associated with Phenergan Tablets and Suppositories overdose.

Anticholinergics - Concomitant use of other agents with anticholinergic properties should be undertaken with caution.

Monoamine Oxidase Inhibitors (MAOI) - Drug interactions, including an increased incidence of extrapyramidal effects, have been reported when some MAOI and phenothiazines are used concomitantly. This possibility should be considered with Phenergan Tablets and Suppositories.

Toxicity mild depression of the central nervous system and cardiovascular system to profound hypotension, respiratory depression, unconsciousness, and sudden death. Other reported reactions include hyperreflexia, hypertonia, ataxia, athetosis, and extensor-plantar reflexes (Babinski reflex). LD50=55mg/kg (I.V. in mice)
Organisms Affected Humans and other mammals
Chemical IUPAC Name N,N-dimethyl-1-(10H-phenothiazin-10-yl)propan-2-amine
Chemical Formula C17H20N2S
Molecular Weight 284.42 g/mol
Smiles String CC(CN1C2=CC=CC=C2SC3=CC=CC=C31)N(C)C
Melting Point 60°C
Water Solubility Freely soluble
State white to faint yellow, practically odorless, crystalline powder
LogP/Hphobicity 4.946
Isoelectric Point Not Available
Biotransformation Hepatic
Half Life 16-19 hours
Protein Binding [%] 93%
RxList Link RXlist
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Drug Reference http://www.drugs.com/cons/Promethazine.html
http://www.rxlist.com/cgi/generic3/phenergan.htm
Drug Type Approved Drug
Accession No APRD00601
CAS Registry Number 60-87-7
KEGG Compound ID C07404
PubChem ID SID:278510
PharmGKB ID Not Available
SwissProt ID Not Available
GenBank ID Not Available
Drug ID Number [DIN] 583979

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